Renal Phys--> Body fluid compartments

Question 1

What is the plasma solute concentration? Less than or greater than expected? why?

Answer 1

280mM

slight less than 300mM because some is bound to albumin

Question 2

What makes up an anion gap?

Answer 2

Na-(Hco3- + Cl-)

• should be around 10-15
• 140-(25+105)= 10

Question 3

What is osmolality?

Answer 3

Total free solute (mM)/Kg of solvent

Question 4

What is osmolarity?

Answer 4

Total free solute (mM)/Liters of solvent

Question 5

What percent of body is made up of water?

Answer 5

60%

55,500mM

Question 6

What is responsible for the oncotic pressure?

Answer 6

Albumin

• about 1.2-1.4mM in solution
• 4.5g/100ml
• exhibits 25mmHg

Question 7

What forms the capillary filtration barrier? What interrupts this?

Answer 7

Glycocalyx

TNF interrupts this in makes caps leaky

Question 8

What is the common intracellular solute makeup?

Answer 8

K 140
Po4-40
Cl 20
Lots of protein
Na 10
Mg 10
So4- 20

Question 9

What makes up common extracellular solute?

Answer 9

Na 140
Cl 105
Hco3- 26
Urea- 6
WOA- 6
Glucose 5
K 4
Ca 4
Mg 1
Albumin-1 
H2p04- 1

Question 10

What is iso-osmotic?

Answer 10

Any soln that has 300mOsoms which is physiologic

- NS, D5, Lactated ringers

Question 11

What is isotonic?

Answer 11

Any soln that does not change volume of cell

- NS

Question 12

What is isoncotic?

Answer 12

Any soln with 1mM of plasma albumin or 4.5 grams/100ml

Any soln that exibits 25 mmHg to oncotic pressure

Question 13

What makes up NS and 1/2 ns?

Answer 13

150 and 150 Na:Cl in NS

77 and 77 Na:CL in 1/2NS

Question 14

What makes up lactated ringers?

Answer 14

130 na, 109 cl, 4 K, 4 Ca and 28 lactate

Question 15

What is intracellular, interstitial and plasma water percentage?

Answer 15

2/3 intracellular
1/3 extracellular
a. 3/4 of that in interstium
b. 1/4 of that in plasma