Renal Path 1 Flashcards
Where is visceral epithelium incorporated into?
Capillary wall-podocytes
Where is parietal epithelium?
Lining Bowman’s space
What type of collagen monomers form the backbone of the GBM?
Type IV collagen
What is the antigenic site in anti-GBM nephritis?
NC1 (nonollagenous domain at carboxyl terminus of collagen helix)
What do the podocytes interdigitate with?
Lamina rara externa
Name 2 slit diaphragm proteins
Nephrin and podocin
What type of cells make scars?
Mesangial cells (of mesenchymal origin)
What is the number one cause of acute renal failure?
Renal tubular necrosis (often due to ischemia)
What does the macula densa detect?
Cl- delivery
Which type of renal disease is typically immune mediated?
Glomerular
Which type of renal disease is usually due to toxic/ischemic and inflammatory reactions?
Tubulointerstitial
Which type of renal disease is ususally due to some occlusiveness or vasculitis?
Vascular
What is azotemia?
increased BUN and creatinine
What is uremia?
Azotemia + clinical symptoms (gastroenteritis, anemia, peripheral neuropathy, pruritis, pericarditis etc.)
What will you hear in a bread & butter uremic pericarditis?
3 component friction rub