PBL 3 HSP

Question 1

What are 2 general reasons BP may increase in persons with renal injury?

Answer 1

1. Increased fluid retention
2. Vessel stenosis (kidneys getting less volume flow so they think there is a systemic hypotension and in turn activate RAAS)

Question 2

Nephritic vs. Nephrotic?

Answer 2

Nephritic: Less than 3.5 g/day protein, moreso due to inflammation and GBM disruption. Will see Azotemia and oliguria because of decreased GFR, Hematuria, RBC casts

Nephritic: massive proteinuria, hypoalbuminemia, edema…All due to Podocyte disruption so large molecules can get through!

Question 3

Compare genetic association studies to GWAS.

Answer 3

Genetic association: studying one gene or a few genes

GWAS: Massive data

Question 4

Describe the process of hematuria in HSP.

Answer 4

Immune complexes deposit in small vessels–> inflammation –>necrosis of kidney vessels –>leakage of blood into urine

Question 5

What type of hypersensitivity is going on in HSP?

Answer 5

Type III-Arthus (vasculitis due to immune complex deposition).