Renal Part I Flashcards
What are the functions of the kidney?
Regulation of extracellular fluid volume and BP
-Renin synthesis (increases BP and blood volume)
Regulation of osmolarity and iron balance
Homeostatic regulation of pH
Erythropoietin synthesis
-Releases retics from bone marrow
Vit D synthesis (active form)
-Regulates mineral homeostasis
Gluconeogenesis in times of starvation
Waste removal
Acidosis
pH is <7.38
Life is threatened when <7.25
Death occurs if <7
Alkalosis
pH is >7.42
Very dangerous when pH is >7.55
Death occurs when pH is >7.6
Regulation of pH
The pH of urine may vary from as low as 4.5 to as high as 9.8 depending on what condition the kidney is trying to overcome
Kidneys can:
-Excrete H+ ions
-Reabsorb bicarb
-Excrete titratable acid (net acid excretion)
-Excrete NH4+ (ammonium)
Waste removal
Afferent arterioles bring blood from the renal artery (dirty blood) into the glomerulus of the nephron
Efferent arterioles carry filtered blood away from the glomerulus
Afferent arterioles are larger, causing a pressure buildup within the glomerulus which facilitates waste removal
Waste removal: glomerular capsule
The glomerular capillary wall determines what is filtered and how much is filtered
It has three layers:
-Endothelium: allows plasma proteins and fluid through, but not RBCs
-Basement membrane: prevents plasma proteins exiting the bloodstream
-Epithelium: filtration level of fluid within the glomerular space (podocytes)
Causes of vit D deficiency
Sun: -Sunscreen -Melanin -Latitude -Winter Meds and supplements -Antiseizure meds -Glucocorticoids -Rifampin -HAART -St. John's wart Hepatic failure Renal failure Nephrotic syndrome Obesity Malabsorption -Crohn's -Whipple -CF -Celiac -Liver dz
Vit D deficiency consequences
Schizophrenia Depression Infections -URI -TB Decreased FEV1 Asthma and wheezing diseases HBP CHD AODM Syndrome X Autoimmune diseases -Type 1 DM -MS -Crohn's -RA Cancer -Breast -Colon -Prostate -Pancreas Muscle weakness Muscle aches Osteoarthritis Osteomalacia Rickets
Excretion
The nephron is the basic structural and functional unit of the kidney which allows for filtration
Fluid passes through the tubules and is modified either by reabsorption or secretion
Reabsorption removes substances from the filtrate back into the system
Secretion adds substances to the filtrate for excretion
Fluid enters Bowman’s space then into the loop of Henle. The bulk of the filtered solute and water are resorbed
The collecting tubules make the final urinary composition changes and allow solute and water excretion to vary with alteration in dietary intake
Renal corpuscle
Production of filtrate
Proximal convoluted tubule
Reabsorption of water, ions, and all organic nutrients
Loop of Henle
Further reabsorption of water (descending limb) and both sodium and chloride ions (ascending limb)
Distal convoluted tubule
Secretion of ions, acids, drugs, toxins
Variable reabsorption of water, sodium ions, and calcium ions (under hormonal control)
Collecting duct
Variable reabsorption of water and reabsorption or secretion of sodium, potassium, hydrogen, and bicarb ions
Papillary duct
Delivery of urine to minor calyx
BUN
Nl range 3-20 mg/dL
Urea is produced as a byproduct of metabolism in the liver which is then released into the blood to be removed in the urine
A measure of renal function (and liver function)
High BUN levels generally indicate poor renal function
Things that elevate BUN
Urinary tract obstruction CHF or recent MI Severe GI bleeding Dehydration/hypovolemia High protein diet Certain meds, esp abx RENAL FAILURE
Things that may decrease BUN
Severe liver dz
Anabolic state (starvation)
SIADH
Creatinine
Chemical by-product of muscle function
Nl range: 0.6-1.2 mg/dL
Produced by creatine
About 2% of body’s creatine is converted to ccreatinine daily
Transported through the blood to the kidneys, whose job is to filter out and dispose most of it
Muscle mass doesn’t change daily, so creatinine shouldn’t either
Causes of elevation in creatinine
Dehydration Dietary supplements Large meat intake Meds -Cimetidine -Trimethoprim -Ranitidine -Ceaphalosporins -Fenofibrate Medical conditions -DKA -Pyelonephritis -Urinary tract obstruction -Rhabdomyolysis KIDNEY FAILURE
Causes of decrease of creatinine
Generally less worrisome than increase
Decreased muscle mass (aging, dz)
Ultra low protein diet (not uncommon in vegans)
Pregnancy
Cachexia (severe malnutrition, cancer)
Severe liver dz (interferes with creatinine production)
Clearance
Rate at which a substance is removed from plasma
How much blood the kidneys can make creatinine free in one min
What is CrCl used to estimate?
GFR
GFR
Measures how well kidneys are filtering blood
Reduced GFR= retention of nitrogenous waste
There is a ______ relationship between clearance and serum creatinine
Inverse
FENA
Fractional excretion of Na
Used to help differentiate pre-renal vs extra-renal process
What does an FENA <1% indicate?
Prerenal cause, volume depletion
Kidney corrects for low fluid state by reabsorbing Na, indicates functional kidney
Hypovolemia, CHF, RAS, sepsis, contrast-induced nephropathy will often look pre-renal
What does an FENA > 1 % indicate?
ATN
Failing kidney, cannot compensate, leaks sodium, indicates kidney dx
Acute kidney injury
Refers to sudden loss or deterioration of kidney function resulting in an inability to maintain acid-based, fluid and electrolyte balance and to excrete nitrogenous wastes
RIFLE criteria
The most commonly used criteria for determining the severity and extent of renal failure Risk Injury Failure Loss (of function) End stage renal dz (ESRD)
Risk and GFR criteria
Increased creatinine x 1.5 or GFR decrease >25%
Risk and urine output criteria
UO < 0.5 mL kg-1h-1 x 6h
Injury and GFR criteria
Increased creatinine x2 or GFR decrease >50%
Injury and urine output criteria
UO <0.5 mL kg-1h-1 x 12h
Failure and GFR criteria
Increased creatinine x3 or GFR decrease >75% or creatinine >4 mg per 100 mL (acute rise of >0.5 mg per 100 mL)
Failure and urine output criteria
UO <0.3 mL kg-1h-1 x 24h or anuria x 12h
Loss criteria
Persistent ARF = complete loss of renal function >4 wks
AKI- components
Sudden, hours or days, may be reversible Often iatrogenic Can be pre/intra/post renal cause Identify the cause and treat More common in pts with some CKD already present
S/sx of AKI
Nausea and vomiting Malaise AMS HTN Asterixis
Anuria
No urine output OR
<100 cc/24 hrs OR
<0.5 cc/kg/hr
Oliguria
<500 cc/24 hrs OR
<20 cc/hr OR
<1cc/kg/hr