Renal Neoplasia

Question 1

Angiomyolipoma Disease Association

Answer 1

Tuberous sclerosis

Question 2

Classic Triad of RCC (& Important Point)

Answer 2

Hematuria, palpable mass, and flank pain, but all 3 rarely occur together

Question 3

4 Paraneoplastic Syndromes from RCC

Answer 3

Reactive polycythemia from EPO
HTN from renin
Hypercalcemia from PTHrP
Cushing’s from ACTH

Question 4

RCC Possible Anatomic Consequence

Answer 4

Left sided varicocele

Question 5

RCC Gross/Common Histo Findings

Answer 5

Yellow mass

Clear cytoplasms

Question 6

Common Mut in RCC

Answer 6

Loss of VHL (3p) tumor suppressor gene, leading to increased IGF-1 and HIF TF
(can be hereditary AD or sporadic with smoking)

Question 7

Wilm’s Tumor Composition and Demographic

Answer 7

Blastema (immature kidney mesenchyme) in children < 3yo

Question 8

Wilm’s Tumor 2 Syndromes

Answer 8

WAGR - Wilms, Aniridia, Genital abnormalities, mental/motor retardation
Beckwith-Wiedemann Syndrome - Wilms, neonatal hypoglycemia, muscular hemihypertrophy, organomegaly (esp tongue)