renal IV Flashcards
how is nephritic syndrome different than nephrotic?
its an inflammatory process
what type of hypersensitivity reaction is Acute poststreptococcal glomerulonephritis
type III hypersensitivty
how does Acute poststreptococcal glomerulonephritis present?
peripheral and periorbital edema, tea or cola coloured urine, HTN
What will be decreased in someone with Acute poststreptococcal glomerulonephritis?
complement levels due to consumption
What will Acute poststreptococcal glomerulonephritis look like on light microscopy?
glomeruli are enlarged and hypercellular
what will Acute poststreptococcal glomerulonephritis look like on IF?
starry sky granuar appearance (lump-bump) due to igG, igM, C3 deposition along GMB and mesangium
what will Acute poststreptococcal glomerulonephritis look like on EM
subepithelial IC humps
what is rapidly progressive (crescentic glomerulonephritis)
a severe form of glomerulonephritis with a poor prognosis -rapid determination (days to weeks)
what will be seen on light microscopy of what is rapidly progressive (crescentic glomerulonephritis)
crescent moon shape
what makes up the crescent moon shape in rapidly progressive (crescentic glomerulonephritis)
fibrin and plasma proteins, with glomerular parietal cells, monocytes, macrophages
what are the different patterns that may be seen on IF in someone with rapidly progressive (crescentic glomerulonephritis)?
linear IF
negative IF/pauci-immune
Granular IF
explain the linear IF pattern in rapidly progressive (crescentic glomerulonephritis)?
formed by antibodies due to GBM and alveolar basement membrane
whats an example of a rapidly progressive (crescentic glomerulonephritis) with a linear IF?
goodpasture
What is goodpasture syndrome?
hematuria/hemoptysis; type II hypersensitivty reaction
how to treat goodpasture
plasmapheresis
explain the negative IF/pauci-immune form of rapidly progressive (crescentic glomerulonephritis)?
no ig/c3 depositino
example of explain the negative IF/pauci-immune form of rapidly progressive (crescentic glomerulonephritis)?
granulomatosis with polyangiitis (Wegener) and microscopic polyangiitis
What are the granular types of rapidly progressive (crescentic glomerulonephritis)?
poststreptococcal glomerulonephritis and diffuse proliferative glomerulonephritis
What is diffuse proliferative glomerulonephritis associated wtih?
SLE
diffuse proliferative glomerulonephritis findings in light light microscropy
‘wire looping’ of capillaries
diffuse proliferative glomerulonephritis findings on IF and EM
granular on If
EM - subendothelial and sometimes intramembranous igG-based ICs often with C3 deposition
What is igA nephropathy?
episodic hematuria that occurs with respiratory or GI tract infections
What will you seen on LM and IF of igA nephropathy?
LM - mesangial proliferation
IF-IgA based IC deposits in mesangium
What is alport syndrome
a mutation in type IV collagen -> thinning and splitting of glomerular BM
