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Renal ERIN > renal IV > Flashcards

renal IV Flashcards

1
Q

how is nephritic syndrome different than nephrotic?

A

its an inflammatory process

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2
Q

what type of hypersensitivity reaction is Acute poststreptococcal glomerulonephritis

A

type III hypersensitivty

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3
Q

how does Acute poststreptococcal glomerulonephritis present?

A

peripheral and periorbital edema, tea or cola coloured urine, HTN

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4
Q

What will be decreased in someone with Acute poststreptococcal glomerulonephritis?

A

complement levels due to consumption

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5
Q

What will Acute poststreptococcal glomerulonephritis look like on light microscopy?

A

glomeruli are enlarged and hypercellular

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6
Q

what will Acute poststreptococcal glomerulonephritis look like on IF?

A

starry sky granuar appearance (lump-bump) due to igG, igM, C3 deposition along GMB and mesangium

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7
Q

what will Acute poststreptococcal glomerulonephritis look like on EM

A

subepithelial IC humps

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8
Q

what is rapidly progressive (crescentic glomerulonephritis)

A

a severe form of glomerulonephritis with a poor prognosis -rapid determination (days to weeks)

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9
Q

what will be seen on light microscopy of what is rapidly progressive (crescentic glomerulonephritis)

A

crescent moon shape

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10
Q

what makes up the crescent moon shape in rapidly progressive (crescentic glomerulonephritis)

A

fibrin and plasma proteins, with glomerular parietal cells, monocytes, macrophages

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11
Q

what are the different patterns that may be seen on IF in someone with rapidly progressive (crescentic glomerulonephritis)?

A

linear IF
negative IF/pauci-immune
Granular IF

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12
Q

explain the linear IF pattern in rapidly progressive (crescentic glomerulonephritis)?

A

formed by antibodies due to GBM and alveolar basement membrane

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13
Q

whats an example of a rapidly progressive (crescentic glomerulonephritis) with a linear IF?

A

goodpasture

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14
Q

What is goodpasture syndrome?

A

hematuria/hemoptysis; type II hypersensitivty reaction

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15
Q

how to treat goodpasture

A

plasmapheresis

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16
Q

explain the negative IF/pauci-immune form of rapidly progressive (crescentic glomerulonephritis)?

A

no ig/c3 depositino

17
Q

example of explain the negative IF/pauci-immune form of rapidly progressive (crescentic glomerulonephritis)?

A

granulomatosis with polyangiitis (Wegener) and microscopic polyangiitis

18
Q

What are the granular types of rapidly progressive (crescentic glomerulonephritis)?

A

poststreptococcal glomerulonephritis and diffuse proliferative glomerulonephritis

19
Q

What is diffuse proliferative glomerulonephritis associated wtih?

A

SLE

20
Q

diffuse proliferative glomerulonephritis findings in light light microscropy

A

‘wire looping’ of capillaries

21
Q

diffuse proliferative glomerulonephritis findings on IF and EM

A

granular on If

EM - subendothelial and sometimes intramembranous igG-based ICs often with C3 deposition

22
Q

What is igA nephropathy?

A

episodic hematuria that occurs with respiratory or GI tract infections

23
Q

What will you seen on LM and IF of igA nephropathy?

A

LM - mesangial proliferation

IF-IgA based IC deposits in mesangium

24
Q

What is alport syndrome

A

a mutation in type IV collagen -> thinning and splitting of glomerular BM

25
Q

how is alport syndrome inherited?

A

X linked

26
Q

presentation of alport

A

eye problems, glomerulonephritis and sensorineural deafness

27
Q

what will be seen on the EM of someone with alport syndrome?

A

basket weave

28
Q

what is membranoproliferative glomerulonephritis?

A

a nephritic syndrome that co-presents with nephrope. Includes Type 1 and type 2

29
Q

what is type I membranoproliferative glomerulonephritis? ?

A

occurs sendarily to hep B or C or is ideopathic ->subednothelial immune complex deposits with granula IF

30
Q

what is type II membranoproliferative glomerulonephritis?

A

associated with C3 nephritic factor (igG autoantibody that stabilizes C3 convertase) ->intramembranous dense deposits

31
Q

what is the characeristic appearance of membranoproliferative glomerulonephritis?

A

tram track appearnce due to GBM splitting

Renal ERIN (5 decks)

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