Renal Histology - Herron Flashcards

1
Q

Name the parts of the nephron in order starting with the proximal convoluted tubule

A

PCT, [PST, TDLH, TALH, MTAL,] MD, DCT, CS

[Loop]

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2
Q

What is a duct of Bellini?

A

Duct in the renal papilla that drains the urine into minor calicoes

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3
Q

Compare the morphology of proximal and distal tubules

A

Proximal: larger with less defined epithelial border
Distal: smaller with very sharp line epithelial border

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4
Q

Compare the morphology of the CD, thick segment, and thin segment

A

CD: cuboidal border, border between adjcent cells
Thick: cuboidal border
Thin: squamous border (flat!)

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5
Q

Most tubules near a renal corpuscle are…

A

proximal probably

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6
Q

Podocytes give rise to which layer of Bowman’s capsule?

A

Visceral

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7
Q

What are mesangial cells and what things do they secrete?

A

Phagocytose debris; structural support; secrete IL-1 and PDGF to repair glomerulus

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8
Q

Morphologically, how do you distinguish the corticomedullary boundary?

A

Where renal corpuscles stop

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9
Q

What are the two histological parts of the cortex?

A

Cortical labyrinths and medullary rays

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10
Q

What is in the cortical labyrinths?

A

corpuscles, PCT, DCT

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11
Q

What is in the medullary rays?

A

Straight tubules and collecting ducts

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12
Q

What is contained in a lobule?

A

A medullary ray and half of the labyrinth on each side

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13
Q

What is the arteriole rectae?

A

Efferent arterioles from the juxtamedullary glomeruli descend into the medulla to form these arteries

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14
Q

What is the arteriole rectae counterpart for cortical glomeruli?

A

Peritubular capillary network

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15
Q

Follow the plasma as it is filtered out - what does it pass through to get to the urinary space?

A

Plasma–>through endothelial fenestrations–> through glomerulus BM–> through podocyte BM –>through slit pore

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16
Q

What is the Lamina rara externa

A

adjacent to the podocyte processes - specifically impede the passage of negatively charged molecules

17
Q

What is the Lamina rara interna

A

adjacent to the capillary endothelium. It molecular features are similar to those of lamina rara externa

18
Q

What is the Lamina densa

A

overlapping portion of the two basal laminae - rara externa and intern

19
Q

Nephrotic syndrome has these three components

A

Proteinuria
Hypoalbuminemia
Edema

Seen in DM due to leaky basal lamina

20
Q

Which cells activate the renin-angiotensin…

A

Juxtaglomerular cells by releasing renin

21
Q

What are the general histological structures of the ureter and bladder?

A

Mucosa, muscularis, adventitia

22
Q

Which parts of the ureter/bladder/urethra are lined by transitional epithelium?

A

Everything except lower urethra

23
Q

Describe muscularis

A

Inner longitudinal
Middle circular
Outer longitudinal

Outer only present at lower ureter