Renal/GU Flashcards

1
Q

Fatty casts

A

Nephrotic syndrome

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2
Q

Broad waxy casts

A

Chronic renal failure

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3
Q

WBC casts

A

Interstitial nephritis or pyelonehritis

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4
Q

RBC casts

A

glomerulonephritis

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5
Q

Muddy brown casts

A

ATN

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6
Q

Path in hypertensive nephropathy?

Diabetic nephropathy?

A

HTN: Hyaline arteriosclerosis in afferent arteriole only, glomerular tufts
DM: Hyaline arteriosclerosis in both afferent and efferent arteriole, glomerulosclerosis (nodular or diffuse) increased ECM/fibrosis, thick BM, and mesangial expansion

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7
Q

First renal abnormality in diabetic nephropathy? First thing noticeable on pathology?

A

First thing: Glomerular hyperfiltration

Biopsy: GBM thickening

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8
Q

Nodular glomerulosclerosis

A

Specific to diabetic nephropathy (K-W nodules will be seen)

Although diffuse glomerulosclerosis is more common in diabetic nephropathy

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9
Q

Type of acid-base abnormality that can be seen in elderly, poorly controlled diabetics

A

Type IV RTA (dysfunctional JG apparatus leads to hyporeninemic hypoaldosterone)

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10
Q

Most common form of HIV-associated kidney disease

A

FSGS (also associated with obesity, heroin, and AA race)

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11
Q

Kidney disease associated with hepatitis B

A

Membranous nephropathy (also seen in SLE, adenocarcinoma, NSAIDs)

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12
Q

Kidney disease associated with hepatitis C

A

Mempranoproliferative glomerulonphritis

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13
Q

BUN/Cr, urine osmolarity, and urine sodium in ATN

A

BUN/Cr < 20 (intrinsic AKI)
Urine osmolarity 300-350 (inability to concentrate urine)
Urine Na >20, FeNa >2%

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14
Q

Kidney injury with acyclovir

A

Crystal-induced nephropathy (also seen with ethylene glycol, sulfonamides, methotrexate, protease inhibitors)

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15
Q

Renal disease classically associated with renal artery thrombosis

A

Membranous nephropathy (but any nephrotic syndrome can cause, due to hypercoagulability)

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16
Q

Nephrotic syndrome with restrictive cardiomyopathy, organomegaly, macroglossia, easy bleeding/bruising

A

AA amyloidosis (in chronic inflammatory state)

Also can see waxy skin thickening, neuropathy and stroke. Easy bleeding/bruising due to fragile vessels

17
Q

Hypertension, microhematuria, and a palpable right flank mass

A

ADPKD (both kidneys enlarged, but easier to palpate on right)

18
Q

Time course and complement in:

  • IgA nephropathy
  • Post-infectious glomerulonephriti
A

IgA: Synpharyngitic, normal complement

Post-infectious GN: Delayed 10-21 days, low complement

19
Q

Nephritis with eosinophiluria or eosinophilia

A

Allergic interstitial nephritis
(Commonly due to drugs like cephalosporins, penicillins, sulfonamides, diuretics, NSAIDs, rifampin, phenytoin, allopurinol. Stop the drug to treat).

20
Q

Analgesic nephropathy

A

Chronic NSAIDs leading to tubulointerstitial nephritis (WBC casts) and/or papillary necrosis (hematuria)

21
Q

How can calcium and phosphorous go wrong in CKD?

A

Secondary hyperparathyroidism due to hypocalcemia (vitamin D deficiency) and hyperphosphatemia (phosphate retention in the kidney)

22
Q

Treatment for uremic platelet dysfunction

A

DDAVP (increases levels of factor VIII/vWF that activates platelets)

23
Q

Most common side effect of EPO in CKD

A

Worsening HTN (HA and flulike symptoms can also be seen)

24
Q

Treatment for uric acid kidney stones

A

Acidify the urine with oral potassium citrate (uric acid stones only form in patients with unusually alkaline urine)

25
Recurrent radioopaque kidney stones with hexagonal crystals in the urine. Diagnostic test?
Cystinuria. Urinary cyanide nitroprusside test
26
Drugs for urge incontinence
Anticholinergics like oxybutynin
27
Medications associated with priapism
Trazadone and prazosin (alpha1 blocker)
28
Marker(s) produced by Leydig cell testicular tumor
Testosterone and estrogen
29
Marker(s) produced by yolk sac / endodermal sinus testicular tumor
AFP
30
Marker(s) produced by choriocarcinoma testicular tumor
beta-HCG
31
Marker(s) produced by seminoma testicular tumor
Usually none