Renal Excretion Flashcards
1
Q
Different routes of excretion (and what is the most important one?)
A
- Most important = in the kidney through urine
- By the lungs
- Through the skin
- Via the liver
- By the bile
- To the intestins
- By hair
2
Q
Clearance definition
A
volume of blood from which the drug is completely removed
3
Q
Creatinine is eliminated by …
A
The kidney (special, because most often it is a combination of organs)
4
Q
Metmorfin function
A
anti-diabetes drug for diabetes mellitus type 2, reduces plasma glucose
5
Q
Renal excretion depends on
A
- Renal blood flow (1100 ml/min)
- GLomerular filtration rate (125 ml/min)
- Urine flow (1-2 ml/min)
- Urine pH (4,5-8)
6
Q
Renal excretion consists of 3 processes:
A
- Glomerular filtration
- Active tubular secretion
- Tubular reabsorption
7
Q
Why do older patients need less drug?
A
because the GFR is lower
8
Q
what drugs are most easily reabsorbed?
A
lipophilic drugs
9
Q
What does the pH to de reabsorption of a drug
A
the lower the pH, the less reabsorption of a drug
