Clearance

Question 1

Halfwaarde tijd

Answer 1

Tijd waarin de helft van het medicijn uit je lichaam is

Question 2

Elimination

Answer 2

Metabolism and excretion. The drug doesn’t have to be out of the body to be eliminated

Question 3

Excretion

Answer 3

Removal of the drug from the body

Can be active of passive

Question 4

When is a constant amount removed?

Answer 4

When there is more substrate then there are pumps

Question 5

Why is only a fraction of the drug removed when there are enough pumps?

Answer 5

Not all the drug is in the blood, so not everything can be removed by the kidney

Question 6

Per cycle, a fixed % is cleared: true of false?

Answer 6

True

Question 7

Q

Answer 7

Bloodflow

Question 8

C_A

Answer 8

Arterial concentration

Question 9

C_V

Answer 9

Venous concentration

Question 10

Formule: Amount that passes the pump (kidney)

Answer 10

Q x C_A

Question 11

Formule: Amount removed

Answer 11

Q (C_A - C_V)

Question 12

Formule: Removed fraction

Answer 12

C_A - C_V / C_A

Question 13

Formule: Clearance

Answer 13

(C_A - C_V / C_A) x Q

Question 14

Clearance definition

Answer 14

The volume from which the drug is removed

Question 15

Formule: More practical way to measure the clearance

Answer 15

Cl x C_A = Q (C_A - C_V)

Dat laatste is the amount removed en dat is makkelijk meten dan dialysis

Question 16

Formule: dose

Answer 16

Dose = Vd x C0 / F = clearance X AUC

Question 17

Dose is related to AUC

- What happens when you have a steeper curve than before?

Answer 17

Lower clearance, so bad kidney function

Question 18

Dose is related to AUC

- What happens when your curve bends instead of it being linear

Answer 18

when the dose gets higher, you get a even higher exposure

Question 19

AUC definition

Answer 19

the exposue of the drug to the body