Half life and steady state

Question 1

What happens with the clearance when the Vd increases? Why?

Answer 1

The clearance decreases, because more volume needed to clear

Question 2

What happens when the clearance decreases with the curve?

Answer 2

Becomes less steep

Question 3

Ke =

Answer 3

Elimination rate

Question 4

T1/2 =

Answer 4

Half time = time to 50%

Question 5

What happens to the half life when the clearance goes up?

Answer 5

Half life decreases

Question 6

What happens to the half life when the Vd goes up?

Answer 6

Half life increases

Question 7

Steady state concentration =

Answer 7

Css = amount of drug that goed in is the same as the amount of drug excreted

Question 8

Amount removed is het zelfde als

Answer 8

Infusion Rate (IR)

Question 9

Formule: Infusion Rate

Answer 9

Q( C_A - C_V)

Question 10

Formule: Css (steady state concentration)

Answer 10

Css = IR / Cl

Question 11

after how much infusions do you reach steady state concentration (Css)?

Answer 11

After 4 or 5 infusions

Question 12

What is a solution to reach Css earlier when the T1/2 is way too long? (like 30 hours)

Answer 12

Giving a starting dose

Question 13

What do you need to do when you increase the Css from 100% to 150%?

Answer 13

change the starting concentration and increase infusion rate

Question 14

What happens to de Css when there is kidney failure?

Answer 14

Css goed up

Question 15

2 situations of oral administration:

Answer 15

• High absorption

- Slow absorption