Renal Dose Adjustment Flashcards
1
Q
criteria for ckd
A
- markers of kidney damage
- decrease gfr
2
Q
what are markers of kidney damage
A
- albuminuria
- urine sediment abnormalities
- electrolyte abnormalities
- abnormal histology
- abnormal imaging
- history of kidney transplant
3
Q
what is decreased gfr
A
<60 ml/min/1.73 msq
4
Q
how to estimate gfr
A
- plasma or urinary clearance
- serum creatinine
- normal gfr: 90 mL/min/1.73 msq or higher
5
Q
steps in renal dose adjustment
A
- history and pe
- estimate egfr
- compute for usual dosing
- compute for renal dose
6
Q
drugs that require dose adjustment
A
- beta blockers
- ace inhibitors/arbs
- nsaids, opioids
- diuretics
- diabetes medications
- cholesterol medications
- antimicrobials
- misc
- psychotropics
7
Q
recommended method to estimate gfr for adults
A
ckd-epi creatinine 2009 equation
8
Q
useful confirmatory test for ckd in patients with dec gfr
A
ckd-epi cystatin and creatinine 2012 equation
9
Q
gfr calculation for children 1-17 years old
A
revised bedside schwartz formula
10
Q
how to compute for usual dosing
A
adults: pharma
child: mkd
11
Q
how to compute for renal dose
A
decrease dose or decrease interval or both
