Renal Disease Part 1 Flashcards
Classifications of Renal Diseases (3)
- Glomerular disorders
majority are of immune origin (immune complexes, IgG, IgA) - Tubular disorders
- Interstitial disorders
AKA “Kimmelstiel Wilson Disease”
Diabetic Nephropathy
Deposition of glycosylated proteins on the glomerular basement membranes caused by poorly controlled blood glucose levels
Diabetic Nephropathy
Diabetic Nephropathy findings:
(+)micral test (microalbuminuria)
Most common caused of end-stage renal disease
Diabetic Nephropathy
Decrease GFR (<25mL/min)
Azospermia (Increase BUN and Creatinine) Electrolyte imbalance
(-) renal concentrating abilityIsosthenuria Proteinuria and Renal glycosuria
Increase telescoped sediments
Renal Failure
Increase cells and casts, lipid droplets, oval fat bodies
Telescoped Sediment
Renal Calculi/Renal Lithiasis Primary urinalysis finding:
Microscopic Hematuria
Conditions Favoring the Formation of Renal Calculi: (3)
• Chemical concentration
•pH
• Urinary stasis (decrease urine flow)
Renal calculi (5)
A. Calcium oxalate calculi
B. Uric Acid and Urate Calculi
C. Cystine Calculi
D. Phosphate calculi
E. Magnesium ammonium phosphate/ triple phosphate/ struvite calculi
-Major constituent of renal calculi -most common (80%)
Characteristics:
Very hard, dark in color with rough surface
Calcium oxalate calculi
-associated with increased intake of foods with high purine content
(chicken, bacon, liver, asparagus)
Characteristics:
Yellowish to brownish red and moderately hard
Uric Acid and Urate Calculi
seen in hereditary disorders of cystine metabolism Least common calculi (1-2%)
Characteristics:
Yellow-brown, greasy and resembles an old soap
Cystine Calculi
Pale and friable
Phosphate calculi
Types of kidney stone (6)
Phosphate stones
Oxalate stones
Urate stones
Xanthine stone
Cystine stones
Struvite stones