Renal Disease Part 1 Flashcards
Classifications of Renal Diseases (3)
- Glomerular disorders
majority are of immune origin (immune complexes, IgG, IgA) - Tubular disorders
- Interstitial disorders
AKA “Kimmelstiel Wilson Disease”
Diabetic Nephropathy
Deposition of glycosylated proteins on the glomerular basement membranes caused by poorly controlled blood glucose levels
Diabetic Nephropathy
Diabetic Nephropathy findings:
(+)micral test (microalbuminuria)
Most common caused of end-stage renal disease
Diabetic Nephropathy
Decrease GFR (<25mL/min)
Azospermia (Increase BUN and Creatinine) Electrolyte imbalance
(-) renal concentrating abilityIsosthenuria Proteinuria and Renal glycosuria
Increase telescoped sediments
Renal Failure
Increase cells and casts, lipid droplets, oval fat bodies
Telescoped Sediment
Renal Calculi/Renal Lithiasis Primary urinalysis finding:
Microscopic Hematuria
Conditions Favoring the Formation of Renal Calculi: (3)
• Chemical concentration
•pH
• Urinary stasis (decrease urine flow)
Renal calculi (5)
A. Calcium oxalate calculi
B. Uric Acid and Urate Calculi
C. Cystine Calculi
D. Phosphate calculi
E. Magnesium ammonium phosphate/ triple phosphate/ struvite calculi
-Major constituent of renal calculi -most common (80%)
Characteristics:
Very hard, dark in color with rough surface
Calcium oxalate calculi
-associated with increased intake of foods with high purine content
(chicken, bacon, liver, asparagus)
Characteristics:
Yellowish to brownish red and moderately hard
Uric Acid and Urate Calculi
seen in hereditary disorders of cystine metabolism Least common calculi (1-2%)
Characteristics:
Yellow-brown, greasy and resembles an old soap
Cystine Calculi
Pale and friable
Phosphate calculi
Types of kidney stone (6)
Phosphate stones
Oxalate stones
Urate stones
Xanthine stone
Cystine stones
Struvite stones
Accompanied by urinary infections involving urea-splitting bacteria (Proteus vulgaris)
Characteristics:
Branching/Staghorn calculi resembling antlers of a deer
Magnesium ammonium phosphate/ triple phosphate/ struvite calculi
Rare calculi (5)
A. Sulfonamide Calculi
B. Silica calculi
C. Triamterene calculi
D. Adenine calculi
E. Xanthine calculi
ingestion of silica over a long period of time
Silica calculi
insoluble diuretics; mustard-colored stones
Triamterene calculi
associated with inherited enzyme deficiency &
hyperuricemia
Adenine calculi
associated with a genetic disorder with an absence of xanthine oxidase
Xanthine calculi