INTERSTITIAL DISORDERS

Question 1

Ascending bacterial infection
of the bladder.
Most frequently encountered.
Most common WOMEN and
CHILDREN.
UTI- most common renal
disease
*LOWER UTI: urethra &
Bladder
*UPPER UTI: Renal pelvis,
tubules, interstitium

Acute onset of urinary
frequency and burning
resolved with antibiotics

WBCs, Bacteria
Microscopic Hematuria
Mild Proteinuria
Increased pH
NO CASTS

Answer 1

Cystitis
(LOWER UTI)

Question 2

Infection of the renal tubules
and interstitium related to
interference of urine flow to
the bladder, reflux of urine
from the bladder, and
untreated cystitis.

Acute onset of urinary
frequency, burning and lower
back pain resolved with
antibiotics.

WBCs, Bacteria
WBC Casts
Bacterial Casts
Microscopic Hematuria
Proteinuria

Answer 2

Acute Pyelonephritis
(UPPER UTI)

Question 3

Recurrent infection of the
tubules and interstitium
caused by structural
abnormalities affecting the
flow of urine.

Frequently diagnosed in
children; Requires correction
of the underlying structural
defect and possible
progression to renal failure.

WBCs, Bacteria
WBC Casts
Bacterial Casts
Granular Casts
Waxy and Broad Casts

Hematuria
Proteinuria

Answer 3

Chronic Pyelonephritis

Question 4

Allergic inflammation of the
renal interstitium in response
to certain medications.

Acute onset of renal
dysfunction often
accompanied by a skin rash;
Resolves following
discontinuation of medication
and treatment with
corticosteroids

WBCs (Increase Eosinophils)
WBC Casts
NO Bacterial Casts
Hematuria
Proteinuria

Answer 4

Acute Interstitial Nephritis