Renal Flashcards
UTI symptoms in neonates?
Off feeds
Irritable
Foul smelling urine
UTI symptoms in young children?
Fever
Dysuria
Suprapubic pain
UTI symptoms in older children?
Fever Dysuria Frequency Urgency Suprapubic pain
Investigations in UTI?
Urine dipstick Urine culture KUB ultrasound (anatomical abnormalities) Micturating cystourethrogram DMSA renogram (function/scaring)
Treatment UTI?
Treat according to urine sensitivities
<3 months: refer
>3 months with Lower UTI: Trimethoprim or nitrofurantoin
>3 months with Upper UTI: admit and co-amoxiclav
Commonest bacterial cause of UTI?
E. coli
Risk factors for UTI?
Female Genitourinary malformations Vesicoureteric reflux (VUR) Diabetes Immunosuppression Catheterisation
What is haemolytic uraemic syndrome (HUS)?
E. coli O157:H7 or Shigella enteritis
Viratoxin damage to glomerular endothelial cells
Symptom triad of HUS?
MhAT
Microangiopathic haemolytic anaemia
Acute kidney injury
Thrombocytopenia
(NO FEVER)
Investigations in HUS?
Stool culture
Urinalysis eGFR
FBC, U&E, LFT, LDH
Peripheral blood smear
Treatment in HUS?
Notifiable disease
Generally supportive (IV fluids)
Consider CCB if hypertension
Transfusion/dialysis if severe
What is Henoch-Shönlein Purpura (HSP)?
Systemic vasculitis that presents with typical signs and symtpoms
What causes HSP?
IgA complex deposition in the capillaries, arterioles and venules in organs such as the skin and the kidneys.
Symptoms caused by activation of complement
Symptom triad of HSP?
RAP Renal manifestations: - haematuria - ANCA negative glomerulonephritis Arthralgia and abdominal pain Purpura (typically buttocks and lower limb)
Investigations in HSP?
Urinalysis and eGFR
FBC, EUC, LFT, LDH, CRP, ESR
IgA levels
Skin biopsy if indicated