Renal Flashcards
Goodpasture’s syndrome is an autoimmune disease due to antibody directed at the glomerular basement membrane. The most frequent class of antibody implicated in this disease is
IgG.
Haemolytic uraemic syndrome is a syndrome composing of the triad of:
Microangiopathic haemolytic anaemia
Low platelets, and
Renal failure
MCC of HUS?
E.coli
usually the O157:H7 subtype
Tx of SIADH
Demeclocycline
post strep vs minial change?
post strep = protein and blood
minimal = protein alone
Struvite stone composition?
AMP, Ammonium , Magnesium and phosphate
ADPKD is associated with?
SAH
How to Dx PKD in pts? (2)
<20 Genetic analysis
>20 US
The mainstay of treatment of AIN? i
withdraw any drug (eg NSAIDs) which may be causative. High-dose prednisolone is indicated in some cases to hasten recovery
The history of rapidly worsening symptoms of asthma, accompanied by hypertension, raised creatinine and blood and proteinuria are features of
Churg-Strauss.
Tx of chug strauss?
High dose steroids
with the addition of cyclophosphamide or azathioprine
Tx of choice for tumour lysis syndrome (TLS) secondary to chemotherapy
IV Rasburicase
if that fails, try hemodialysis
PKD 1 found on chromosome?
PKD 2?
Csome =16
c’some 2x2 = 4
Tx of ethylene glycol poisoning;
Fomepizole
Ethanol is also an antidote for ethylene glycol, but if available, fomepizole is the preferred option.
A renal biopsy shows focal deposition of IgG and C3 with a granular pattern is what type of glomerulonephritis?
Membranous glomerulonephritis
clarithromycin interacts with——-especially in those with kidney transplant
cyclosporine
A young man presenting with
renal failure,
haematuria and
liver and renal masses raises the suspicion of
polycystic kidney disease.
IgA nephropathy vs Post Strep?
IgA after 3 days
post strep after 1 to 3 weeks
Effacement of podocytes on electron microscopy think ?
Minimal change
Humps in the subepitheilal space on electron microscopy think?
post strep
IgA deposition in the mesangium
IgA Nephropathy
The tram track appearance on light microscopy represents
membranoproliferative glomerulonephritis
P-ANCA is associated with
Polyangitis
anti-cytoplasmic ANCA (c-ANCA) positivity is associated with?
Wegener’s granulomatosis
The features of shoulder pain associated with a past history of carpal tunnel syndrome in a patient receiving haemodialysis suggests a diagnosis of
ß2 microglobulin amyloidosis.
What is the most useful therapy to reduce ca stone formation?
Potassium citrate
Both thiazide diuretics and potassium citrate can be used to reduce urinary excretion of calcium. Potassium citrate is generally preferred as it has fewer side effects, and is therefore better tolerated.
