Renal Flashcards
Glomerulonephritis Pathophysiology:
a. Inflammatory reaction in the _______________________.
b. Antibodies lodge in the glomerulus; get scarring & _____________ filtering.
c. Main cause:_______________________
Pathophysiology:
a. Inflammatory reaction in the glomerulus.
b. Antibodies lodge in the glomerulus; get scarring & decrease filtering.
c. Main cause: strep
9 S/S: for Glomerulonephritis 9 S/S: for Glomerulonephritis 1.)Sore throat 2)Facial edema 3.)Malaise and headache 4.)BUN&Creatinine_up 5.)Sediment/protein/blood in urine 6.)UO down 7.)Urine specific gravity up 8.). Flankpain(costovertebralangletenderness) 9.). BP_up Client going into fluid volume \_\_\_\_\_\_\_\_\_\_\_\_\_\_. .
9 S/S: for Glomerulonephritis a. Sore throat b. Malaise and headache c. BUN&Creatinine\_\_\_\_\_\_\_ d. Sediment/protein/blood in urine e. Flankpain(costovertebralangletenderness) f. BP_up g. Facial edema h. UO down i. Urine specific gravity up Client going into fluid volume \_\_\_\_\_\_\_\_\_\_\_\_\_\_.
Tx:5 treat for Glomerulonephritis a. Get rid of the strep. b. Balance activity with rest. c. I and O and daily weights d. Monitor blood pressure. . e. How is fluid replacement determined? • Fluid replacement = 24 hour fluid loss + \_\_\_\_\_\_\_\_\_\_.
Dietary needs:
• Protein? ______ Na? __________ Carbs? _______
Tx:
a. Get rid of the strep.
b. Balance activity with rest.
c. I & O and daily weights
d. Monitor blood pressure.
e. How is fluid replacement determined?
• Fluid replacement = 24 hour fluid loss + 500 cc (for insensible fluid loss).
f. Dietary needs:
• Protein decrease, Na decrease, Carb increase
Why do these occur
Malaise and headache?
BUN &Creatinine up?
describe the color of Sediment/protein/blood in urine ?. What does the color tell you ?how do they leak through ?
Flank pain (costovertebral angle tenderness?
Malaise and headache
Because they are retaining toxins and toxins make you feel funny ( tired)
BUN &; Creatinine up
Because your kidneys aren’t working. You aren’t excreting urea or creatine
Sediment/protein/blood in urine
Urine maybe describe as smoky, Rusty, cola color. This is telling you their is hematorrhea.
There are big holes in the glomerulus so taking leak through.
Flank pain (costovertebral angle tenderness) The doctor may wonder how high in the urinary trac the infection is. So they would tap over the flank pain to determine where the complaint of Tenderness is
The client may have to have _______?. Depending on how bad Glomerulonephritis is
____ begins in ___ to ___ weeks after _____?.
___ and _____ may stay in the urine for ______?.
Because it takes a while for the kidneys to be repaired
The client may have to have dialysis. Depending on how bad Glomerulonephritis is
Diuresis begins in 1___ to _3__ weeks after onset.
Blood and protein may stay in the urine for months.
Because it takes a while for the kidneys to be repaired
For Glomerulonephritis Teach 5 S/S of_renal failure
Most of these s/s are due to
a lot of this is do to the fact the Client is retaining _______ and _______
- ) decreased output
- ) weight gain
- )headache & Malaise
- )nausea, vomiting
- ))anorexia,
•a lot of this is do to the fact the Client is retaining fluids and toxins
how is nephrotic syndrome different from glomerulonephritis?
Nephrotic syndrome-very edematous and losing MASSIVE amounts of protein
What is the Pathophysiology of Nephrotic Syndrome ?
It’s an inflammatory response in the glomerulus→ big holes form so protein starts leaking out in the urine
(what do we call this? Proteinuria)→ Now the client is
hypoalbuminemic (low albumin in the blood)→ without albumin you can’t hold on to fluid in the vascular space→ so where does all the fluid in the vascular space go? TISSUES → Now the client is edematous→ since all the fluid is going out into the tissue what has happened to the circulating blood volume?→
Decreases
The kidneys sense this decreased volume and they want to help replace it→ The
renin-angiotensin system kicks in→ aldosterone is produced→ and causes the
retention of SODIUM and WATER but is there any protein (albumin) in the vascular space to hold it?NO→ So where does this fluid go?TISSUES
Total Body Edema = Anasarca
Problems associated with protein loss: Nephrotic Syndrome
Name the 2 problems ?
Why will the blood clot ? What does it put them at risk for ?
Why will they have elevated Cholesterol and triglycerides?
Blood clots (thrombosis)
They are losing protein that normally prevents their blood from clotting without these proteins, the blood can clot and put them at risk for thrombosis.
• Cholesterol and triglycerides will be HIGH
The liver compensates by making more albumin causing an increased release of cholesterol and triglycerides.
5 Causes; Idiopathic, but has been related too: Nephrotic Syndrome
- )Strep
- )Bacteria or viral infections
- )NSAIDs
- )Cancer and_ Genetic predisposition.
- )Systemic disease like lupus or diabetes
With Glomerulonephritis strep is usually the cause . Just about every time
4 S/S of Nephrotic Syndrome
1) hypoalbuminemia
2) proteinuria (leads to blood clots and high cholesterol too)
3) anasarca (All that 3rd spacing d/t to hypoalbuminemia)
4) hyperlipidemia (caused by hypoalbuminenia, at the liver compensates by making more albumin, which causes increased release of cholesterol and triglycerides)
What is a the 7 TX for Nephrotic Syndrome
Tx:
a.
1. )Diuretics
- )Ace inhibitors
- )Prednisone .
- )Lipid lowering .
- ) Anticoagulation
6.) Na? Decrease
Protein? Increase
This is the one kidney disease where you have to have protein
7.). Dialysis
Nephrotic Syndrome
Why do we give diuretics?
Why do we give ace inhibitors?
Why do we give prednisone?
Why do we give lipid lowering drugs ?
If thrombosis is suspect what do we give ? How long can it be given ?
Why might dialysis be given ?
Tx:
a.
1.)Diuretics
Have to remove the excess fluid
2.)Ace inhibitors to block aldosterone secretion.
3.)Prednisone to decrease inflammation.
Good thing -Shrink holes in the glomerulus→ so Protein can’t get out
Bad thing -It make them Immunosuppressed.
4.)Lipid lowering drugs for hyperlipidemia.
5.)Na? Decrease
Protein? Increase
This is the one kidney disease where you have to have protein
6.) Anticoagulation -If thrombosis is suspected then Anticoagulation therapy for up to 6 months.
•on it for 6 mo.
pt. at risk for blood clots (pt. losing proteins that normally prevents blood from clotting. w/o these proteins, blood can clot and put them at risk for thrombosis)
7.). Dialysis - tthey may also need this to pull off the excess fluid
Rule: Limit protein with kidney problems except with Nephrotic Syndrome
An infusion of what can help this person ?
An infusion of lasix and albumin can help this person
Albumin will pull fluid out the tissue and return it to the vascular space
This could create another problem And cause fluid volume excess.
So we give a lasix with the albumin to Enhance the dieresis
Renal failure requires what and why?
Requires bilateral failure.
Because you can live with just 1 kidney
Renal failure causes
1.) pre, intra and post
Pre renal failure what is it And what are the 4 causes ?
If the heart rate drop below____what are you worried abt?
It take ___mins of poor perfusion to cause tubular necrosis? This means what?
Blood can’t get to the kidneys.
1.)Hypotension
If your hypotensive blood can’t get to kidneys
If the BP drop to about 90 we’re worried abt adequate perfusion
It may take only 20 minutes of poor perfusion to cause acute tubular necrosis= (the kidneys are dying )
This means the kidneys are dying and there’s not much time to deal with it .
2.)Hypovolemic =FVD
3.)Low heart rate. (arrhythmia)
Because co is down
3.)
4.)Any form of SHOCK
Shock kills kidney
Intra renal failure what is And what are the 6causes ?
damage has occurred INSIDE the kidney.
•
Glomerulonephritis
Nephrotic syndrome
DYES used in test such as heart cath and CT scan
Drugs (Aminoglycosides, Mycins)
Malignant HTN (uncontrolled HTN)
And DM causes severe causes severe kidney/vascular damage.
Post renal failure what is And what are the 5 causes ?
FLUID(urine) can’t get out of the kidney
With all of these problem the urine is having trouble getting out of the kidneys
If it can’t get out it’s going to back up and cause renal failure
Enlarged Prostate Kidney stone Tumors Ureteral obstruction Edematous STOMA (Ileal conduit)