Renal Flashcards
Patho of glomerulonephritis
Inflammatory reaction in the glomerulus
Antibodies lodge in the glomerulus leading to scarring and decreased filtering
Main cause of glomerulonephritis
Strep
S/S of glomerulonephritis
Sore throat Malaise and HA-retaining toxins Increased BUN and Creatinine Protein and blood in urine (tea/rust colored) Protein leaks out due to holes in glomerulus Flank pain (CVA tenderness) Increased BP Facial edema Decreased UOP Increased urine specific gravity Client will go into fluid volume excess
Treatment of glomerulonephritis
Decreased protein and Na, increased carbs to prevent breaking down protein for energy
Dialysis
How long will blood and protein stay in the urine with glomerulonephritis?
Months
When does diuresis begin after onset of glomerulonephritis?
1-3 weeks
How is fluid replacement determined?
24 hour fluid loss + 500cc = total replacement
Protein makes BUN do what?
Increase
Patho of nephrotic syndrome
Inflammatory response in the glomerulus, big holes form so protein starts leaking in urine, leads to hypoalbuminemia. Without albumin you can’t hold onto fluid in vascular space, so fluid goes into tissues. (edema) Since all fluid is in tissues, blood volume is decreased. Aldosterone is produced to try to replace blood volume, so Na and water are retained, but there is no albumin to hold it, so more fluid goes to tissues.
Total body edema
Anasarca, occurs with nephrotic syndrome
Problems associated with protein loss
Blood clots, protein keeps blood from clotting
Cholesterol and triglycerides are released from the liver compensation by making more albumin, causing an increased release of cholesterol and triglycerides.
Causes of nephrotic syndrome
Bacterial and viral infections NSAIDs Cancer, genetics Systemic dz like lupus/diabetes Strep
S/S of nephrotic syndrome
Proteinuria
Hypoalbuminemia
Edema (anasarca)
Hyperlipidemia
Tx of nephrotic syndrome
Diuretics ACE inhibitors to block aldosterone Prednisone to decrease inflammation and shrink holes in glomerulus-causes immunosuppression Lipid lowering drugs Decrease Na Increase protein-give lasix, could go into fluid excess Dialysis Anticoagulation therapy for 6 months
One kidney dz when you have to have more protein in diet
Nephrotic syndrome
Renal failure requires what?
Bilateral failure
Causes of renal failure
Pre renal
Intra renal
Post renal
Pre renal failure
Blood can’t get to the kidneys
- Hypotension
- Decreased HR, arrhythmias
- Hypovolemia
- Shock
Intra renal failure
Damage has occurred inside kidney
- Glomerulonephritis
- Nephrotic syndrome
- Dyes with heart cath and CT scans
- Drugs (mycins, nephrotoxicity)
- Malignant HTN (uncontrolled)
- DM causes vascular damage
Post renal failure
Urine can’t get out of kidneys
- Enlarged prostate
- Kidney stone
- Tumors
- Ureteral obstruction
- Edematous stoma (ileal conduit)
S/S of renal failure
Increased creatinine and BUN
Anemia
Initially: increased specific gravity
Fixed specific gravity: lose ability to concentrate and dilute urine, fluid challenge: bolus with 250 mL NS
HTN & HF, retaining fluids
Anorexia, n/v, retaining toxins
Itching frost (uremic frost)-take good skin care
Hyperkalemia
Metabolic acidosis
Retain phos leading to decreased serum Ca and Ca is pulled from bones
Why is there anemia with renal failure?
Not enough erythropoietin-stimulates RBC production
Two phases of acute renal failure
Oliguric
Diuretic
Acute renal failure
Kidneys have been damaged by one of the causes: this damage leads to the oliguric phase