RENAL Flashcards
What is azotemia?
Elevated nitrogen containing compounds (urea, creatinine)
At what 3 locations can azotemia occur?
Pre, renal, or post-renal
If a patient has severe azotemia that is symptomatic and can cause metabolic acidosis and electrolyte disturbances – what is this known as?
Uremia
How do we stage AKI?
RIFLE (risk, injury, failure) class
AKIN (acute kidney injury network) stage
KDIFO (kidney disease improving global outcomes) guideline
What is something that a nurse would call and notify you about that has changed for the patient, that would trigger you to think about AKI?
Decreases in urine output to less than 3ml/kg over 6 hours (or 0.5ml/kg/hr)
**Falls under KDIGO
We should always be checking creatinine levels when someone first enters the hospital, and re-checking. What change would indicate to us AKI?
Rises greater than 0.3mg/dl
**Falls under KDIGO
What are some of the clinical manifestation of AKI?
Often none
Edema, HTN, decreased UO, and changes in labs
What lab changes would you note with AKI?
Albuminuria, increased BUN, hyperkalemia, and hyponatremia
What would be some examples of prerenal azotemia?
Dehydration!!!! → Hypovolemia (may include blood loss)
Prolonged renal ischemia (acute tubular necrosis)
What are the two components of ATN? What causes each?
Ischemia (prolonged pre-renal)
Nephrotoxicity (NSAIDs, Abx, contrast dye)
What are some causes of Renal (intrinsic) Azotemia?
Glomerulonephritis (immune modulated) vs. Nephrosis (ischemia, contrast, toxins, DIC, precipitation)
Nephritis → Immune modulated
Minimal change disease (nephrotic syndrome)
What are some causes of postrenal azotemia?
Urinary obstruction = Prostatism, tumors, calculi, occasional urethra obstruction
What are some classic diagnostic testing we do for AKI?
UA, BUN, Cr, K, Na, Phosphate, Ca, CBC, and Renal/Pelvic US
How do we prevent AKI?
Sustain renal perfusion (fluid balance, blood volume, BP)
Don’t clog the pipes → prepare for planned exposure to contrast dye and check labs before!
What is the #1 most important step for treating AKI?
You must figure out the cause!!!
How do we treat AKI?
Meticulous limitation of intake = water, meds, proteins, K, Na, phosphate
If everything fails then consider a renal consult → Dialysis
What must we have prepped and ready for a renal consult?
BMP, Mg, Phosphate, UA, hemoglobin, and Renal US
What are some underlying medical co-mordidities that can lead to chronic kidney disease?
AKI, HTN, DM, and vascular disease
If the GFR is 60-89, what stage CKD?
2 (mild)
If the GFR is 30-44, what stage CKD?
3B
If the GFR is less than 15, what stage CKD?
5 (end stage)
If we have a patient in the hospital with CKD, what’s out #1 goal?
To prevent the development of acute-on-chronic kidney disease