renal Flashcards
what virus causes Measles mumps and rubella
RNA. paromyoxvrus (measles morbilivirus)
most common viral hepatitis worldwide
route of spread for the viral heps
HEP A
A- FO
B+C - blood
D - always with B
E - Zoo+ FO
child with a high fever and spots on uvula, and as fever settles rash appears ? name and viral cause
roseola
HHV-6
NAGAYAMA spots
what marker is used to distinguish iron overload from haemochromatosis and other causes
transferrin saturations
high in haemochromatosis low in others
lacey rash on kids face - called and virus cause by ?
erythema infectiosum/slapped cheek/ fifths disease
parvovirus B19
what is diagnostic criteria of an AKI
- rise in createnine of 26 within 48 hrs
- an increase of 50% createnine in 7 days
- oligouria (<0.5ml/kg/hr) for > 6 hrs in adults
- 25% fall in eGRF in kids in 7 days
drugs that should be stopped in AKI
ACEI, ARB, NSAID, aminoglyc, diuretic
DIG, met lithium due to toxiciity
what is given in hyperkalaemia to stabalise cardiac memebrane
IV Calcium Gluconate
what size of gallstone can be left to pass psontaneously
<5mm
CKD that causes large not small kidneys
ADPKD
diabetic nephropathy
amyloidosis
HIV assoc nephropathy
most common casue of CKD
diabetic nephropathy
how does scarlet fever casue a rash
GAS releases erythrogenic toxin
what is management of different volvulus
sigmoid volvulus: rigid sigmoidoscopy with rectal tube insertion
caecal volvulus: management is usually operative. Right hemicolectomy is often needed
out of PSC and PBC which is both intra and extr hepatic
PSC is intra and extra
most common complications of measels (2)
otiis media - most common
pneumonia - most common cause of death
where is water reabsorbed from in the kidney
PCT, descending loh and CD
what does ADH do and where does it act
stimulates aquaporin in CD of kidney
in the PCT what is HCO3 resorption driven by
sodium
types of nephrotic syndrome
- minimal change
- membranous GN
- focal segmental glomerulonephritis
- amyloidosis
- diabetic nephropathy
types of nephritic syndrome
- rapidly progressing GN
- IgA nephrpathy
- Alport syndrome
triad of nephrotic syndrome
- proteinuria
- oedema
- hypoalbinaemia
+ hypercholoesterol
what cells does nephrotic syndrome affect
podocytes
how does nephrotic syndrome cause thrombosisi
loss of antithrombin III, protein C and S and associated increase in fibrinogen
what would be seen on renal biopsy in minimal change disease
occasional IgM in mesangium
podocyte foot effacement
causes of minimal change disease
idiopathic
drugs - NSAID
hodgkins
MONO
middle aged itchy woman and treatment
PBC
- first-line: ursodeoxycholic acid
slows disease progression and improves symptoms
- pruritus: cholestyramine
- fat-soluble vitamin supplementation
commonest casue of GN in adults
membranous GN
spikes on renal biopsy
membranous GN
treatment of membranous GN
ACE/ARB
immunisupp
what is the clinical picture of nephritic picture
haematuria
proteinuri <3g
sterile pyuria
HTN
oligouria
what is deposited on the basemenet membraen i nmembranous GN
IgG and C3
IgA nephropathy associated conditions
alcoholic cirrhosis
coeliac. dermatitis herpetiformis
HSP
what anti body is tested for in post streptococcal GN
anti-streptolysin o
what complement protein is low in post strep Gn
C3
starry sky on renal biopsy
post strep Gn
what is seen on renal biopsy in alports syndrome
basket weave - splitting of lamina dense
if someone has renal failure and haemoptysis what shoud you think ?
GPA or goodpasteurs
what chromosome is HLA found on
chromosome 6
different types of renal graft rejection and timeframe
- hyperacute rejection - mins to hrs
- acute graft failure - <6mnths
- chronic graft failure >6mnth
what is the pathogenesis of hyperacute graft failure
due to pre-existing antibodies eg ABO
tx of hyperacute graft rejection
remove transplant