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MOA of local anaesthetics
Block sodium channels
MOA of PSNS drugs
Muscarinic / nicotinic agonist and acetylcholinesterase inhibitors
Alpha 1 vs alpha 2
Alpha 1:
MOA of antipsychotics
Work with dopamine and serotonin (5-HT) receptors (D2 and 5-HT2A)
MOA of antidepressants
Work with serotonin, inhibiting reuptake (SSRI’S and TCA’S). They can also increase release and production (MAO) of neurotransmitters
MOA of benzodiazepines
Bind to GABAa receptors and facilitate GABA binding to open channel, let chloride in and calm us.
MOA antiepilepsy drugs
Calcium / sodium channel inhibitors to inhibit firing. Also GABA facilitatory (benzodiazepines) used in alcoholics.
MOA Parkinson’s drugs
Increases dopamine, inhibits breakdown of dopamine and is a central anticholinergic to stop tremor.
MOA Alzheimer’s disease drugs
Acetyl cholinesterase inhibitors
MOA NSAIDS
Irreversible inhibitor of COX 1 AND COX 2. Except Coxib which is only COX2
MOA glucocorticoids
Inflammation and immunosuppressant. End in -one
Anti migraine drugs
Triptans - antagonist (blocks) serotonin receptors and causes vasoconstriction of cranial arteries.
MOA Antihypertensive drugs
Calcium channel blockers - Vera
ACE inhibitors - pril
Antagonists of AT2 - (blocks angiotensin receptors on BV stopping vasoconstriction) Sartans
Beta 1 vs beta 2
Beta 1:
