Remember!

Question 0

Disease with problem in mismatch repair

Answer 0

Lynch syndrome

• HNPCC
• hallmark: microsatellite instability

Question 1

Expected increase in Hg and Hct for every unit of packed RBC

Answer 1

For every unit of PRBC

• 10 points Hg
• 3 points Hct

Question 2

Enzyme inhibited by 5-FU

Answer 2

Thymidylate synthase

Question 3

Disease that has a problem with thymine dimers

Answer 3

Xeroderma pigmentosum - precursor to all skin CAs

Question 4

Dacrocytes

Answer 4

Aka tear drop cells seen in Primary Myelofibrosis

Question 5

Codocytes

Answer 5

Aka target cells

Question 6

Echinocytes

Answer 6

Aka burr cells - RBCs with spikes

Question 7

Protein absent in smooth muscle

Answer 7

Troponin

Question 8

Functions as troponin c in smooth muscle

Answer 8

Calmodulin

Question 9

Functions as troponin I in smooth muscle

Answer 9

Caldesmon

Calponin

Question 10

Cyclooxygenase product that inhibits platelet aggregation and causes vasodilation

Answer 10

PGI2

Prostacyclin

Question 11

Fabry’s disease - inheritance? Deficiency? What accumulates?

Answer 11

X-linked
Alpha- galactosidase
Globoside

Question 12

Gaucher disease - inheritance? Deficiency? What accumulates?

Answer 12

AR
B-glucosidase
Glucocerebroside

Question 13

Krabbe disease - inheritance? Deficiency? What accumulates?

Answer 13

AR
B-galactosidase
Galactocerebroside

Question 14

Nieman Pick disease - inheritance? Deficiency? What accumulates?

Answer 14

AR
Sphingomyelinase
Sphingomyeline

Question 15

What part of the antibody attaches to the antigen?

Answer 15

Variant portions of both light and heavy chains at the amino terminal end
(Fab region)

Question 16

Granular casts

Answer 16

ATN

Question 17

Fatty cast

Answer 17

Nephrotic syndrome

Question 18

Waxy cast

Answer 18

Chronic renal failure

Question 19

Acid- base problem with loop and thiazide diuretics

Answer 19

Metab alkalosis