Relevant EMCQPC22-3 Flashcards
Neural tube defects (NTDs) are primarily caused by:
a) Insufficient folate supplementation
b) Maternal fever during the second trimester
c) Chromosomal aberrations
d) Fetal exposure to amniotic band syndrome
A
When do neural tube defects typically develop?
a) During the 1st week of pregnancy
b) Between the 3rd and 4th week of pregnancy
c) During the 2nd trimester
d) In the final weeks of pregnancy
Between the 3rd and 4th week of pregnancy
Which end of the neural tube is more commonly affected by spina bifida?
a) Cranial end
b) Caudal end
c) Middle region
d) Both ends equally
b) Caudal end
What is the term used to describe spina bifida without any apparent clinical features?
a) Myelomeningocele
b) Anencephaly
c) Spina bifida occulta
d) Cranial fissure malformation
c) Spina bifida occulta
What is the most severe manifestation of cranial fissure malformations?
a) Myelomeningocele
b) Anencephaly
c) Spina bifida occulta
d) Chiari II malformation
b) Anencephaly
How are neural tube defects often diagnosed during pregnancy?
a) Genetic testing
b) Maternal blood test for alpha-fetoprotein levels
c) Ultrasound examination
d) Fetal MRI
c) Ultrasound examination
What is the primary symptom of myelomeningocele?
a) Bladder dysfunction
b) Cranial cleft formation
c) Cranial fissure malformation
d) Sensory and motor function loss
d) Sensory and motor function loss
Which prenatal marker can be used to detect neural tube defects?
a) Elevated alpha-fetoprotein levels
b) Decreased alpha-fetoprotein levels
c) Elevated hCG levels
d) Decreased hCG levels
a) Elevated alpha-fetoprotein levels
What is the recommended timing for initiating folate supplementation to prevent NTDs?
a) At the time of conception
b) 1 week after conception
c) 4 weeks prior to conception
d) During the 2nd trimester
c) 4 weeks prior to conception
What is the treatment for neural tube defects?
a) Prophylactic administration of antibiotics
b) Fetal surgery during the 1st trimester
c) Administration of anticonvulsant drugs
d) Rapid surgical closure of the defect
d) Rapid surgical closure of the defect
Which drug can interfere with folate metabolism and increase the risk of NTDs?
a) Methotrexate
b) Paracetamol (acetaminophen)
c) Ibuprofen
d) Aspirin
a) Methotrexate
Which of the following is not a maternal risk factor for NTDs?
a) Folate deficiency
b) Pregestational diabetes mellitus
c) Obesity
d) Exposure to amniotic band syndrome
d) Exposure to amniotic band syndrome
What is the most common type of NTD affecting the spine?
a) Myelomeningocele
b) Anencephaly
c) Spina bifida occulta
d) Cranial fissure malformation
d) Cranial fissure malformation
Which genetic abnormality is associated with an increased risk of NTDs?
a) Trisomy 13
b) Trisomy 21
c) Trisomy 18
d) Turner syndrome
c) Trisomy 18
What is the primary cause of NTDs in the fetus?
a) Maternal obesity
b) Maternal fever during the third trimester
c) Fetal exposure to amniotic band syndrome
d) Chromosomal aberrations and other genetic factors
d) Chromosomal aberrations and other genetic factors
What type of neural tube defect is covered by skin and/or connective tissue?
a) Open NTD
b) Closed NTD
c) Myelomeningocele
d) Anencephaly
b) Closed NTD
Which region of the spine is most commonly affected by spinal defects?
a) Cervical region
b) Thoracic region
c) Lumbar or sacral region
d) Coccygeal region
c) Lumbar or sacral region
What is the term used to describe defects at the cranial end of the neural tube?
a) Spina bifida occulta
b) Myelomeningocele
c) Cranial fissure malformation
d) Anencephaly
d) Anencephaly
What is the purpose of prophylactic administration of antibiotics in the treatment of NTDs?
a) Prevent CNS infections
b) Promote fetal brain development
c) Reduce maternal fever
d) Stimulate folate metabolism
a) Prevent CNS infections
Besides folate deficiency, which maternal condition is associated with an increased risk of NTDs?
a) Hypothyroidism
b) Gestational diabetes mellitus
c) Rheumatoid arthritis
d) Hyperthyroidism
b) Gestational diabetes mellitus
Which type of neural tube defect is characterized by a vertebral bone defect without herniation?
a) Lipomyelomeningocele
b) Myeloschisis
c) Myelocele
d) Meningocele
d) Meningocele
What is the most common closed neural tube defect?
a) SPina bifida occulta
b) Lipomyelomeningocele
c) Myelomeningocele
d) Myelocele
a) SPina bifida occulta
Which type of neural tube defect is characterized by a subcutaneous mass in the lumbar or sacral region and contains fat tissue covered by skin?
a) Lipomyelomeningocele
b) Myeloschisis
c) Lipomeningocele
d) Meningocele
c) Lipomeningocele
What is the characteristic feature of Chiari II malformation?
a) Motor loss and flaccid paralysis
b) Hydrocephalus
c) Maternal diabetes and folate deficiency
d) Myelomeningocele
b) Hydrocephalus
why not d??
Myelomeningocele is a type of neural tube defect characterized by the herniation of meninges and parts of the spinal cord through a vertebral bone defect. It is often associated with Chiari II malformation, which involves displacement of the cerebellum and brainstem downward through the foramen magnum. This displacement can obstruct the flow of cerebrospinal fluid (CSF) and lead to hydrocephalus, which is the abnormal accumulation of fluid in the brain.
Which type of neural tube defect is associated with a collection of fat, patch of hair, and normal levels of AFP?
a) Spina bifida occulta
b) Lipomyelomeningocele
c) Myeloschisis
d) Meningocele
a) Spina bifida occulta
What type of neural tube defect is characterized by a subcutaneous mass in the lumbar or sacral region, contains fat tissue covered by skin, and has normal levels of AFP?
a) Lipomyelomeningocele
b) Lipomeningocele
c) Myelocele
d) Meningocele
b) Lipomeningocele
Just confirm with your lectures.
Which neural tube defect is associated with bladder and bowel dysfunction, developmental delays, and cognitive impairment?
a) Pina bifida occulta
b) Myelomeningocele
c) Myeloschisis
d) Myelocele
b) Myelomeningocele
Which neural tube defect is the most severe subtype and is characterized by bare, exposed neural tissue without coverage of meninges, bones, or skin?
a) Pina bifida occulta
b) Lipomyelomeningocele
c) Myeloschisis
d) Myelocele
c) Myeloschisis
confirm this answer with your lectures.