Regulation of Glycolysis via Allosteric control

Question 1

What type of inhibition does ATP have on enzymes of Glycolysis?

Answer 1

feedback inhibition (PFK-1) and product inhibition (PK)

Question 2

Which modulators have a NEGATIVE impact on Glycolysis? Do they increase or decrease enzymatic activity?

Answer 2

ATP, citrate, G6P, acetyl-CoA || decrease activity

Question 3

Which modulators have a POSITIVE impact on Glycolysis?Do they increase or decrease enzymatic activity?

Answer 3

F6P, 2,6-FBP, AMP & ADP || increase activity

Question 4

What type of inhibition does citrate have on enzymes of Glycolysis?

Answer 4

feedback inhibition

Question 5

What type of inhibition does G6P have on enzymes of Glycolysis?

Answer 5

product inhibition

Question 6

What type of inhibition does acetyl-CoA have on enzymes of Glycolysis?

Answer 6

inter-pathway inhibition

Question 7

What type of inhibition does F6P have on enzymes of Glycolysis?

Answer 7

intra-pathway inhibition

Question 8

What type of inhibition does 2,6-FBP have on enzymes of Glycolysis?

Answer 8

activation

Question 9

What type of inhibition does AMP & ADP have on enzymes of Glycolysis?

Answer 9

activation

Question 10

Which modulators decrease the activity of PFK-1?

Answer 10

ATP and citrate

Question 11

Which modulators increase the activity of PFK-1

Answer 11

2,6-FBP and AMP and ADP

Question 12

Which modulators decrease the activity of PK?

Answer 12

ATP and acetyl-CoA

Question 13

Which modulators increase the activity of PK?

Answer 13

F6P and ADP and AMP

Question 14

Which modulators decrease the activity of HK?

Answer 14

G6P