regulation of glycolysis and gluconeogenesis Flashcards
1
Q
which out of hexokinase and glucokinase is product inhibited?
A
hexokinase (glucose 6-p)
2
Q
genetic deficiency of glucokinase
A
MODY 2- impaired insulin secretion from beta cells
3
Q
where is inactive glucokinase located
A
in the nucleus at high fructose 6p levels
4
Q
km and vmax for glucokinase
A
high km and high vmax. low affinity for glucose
5
Q
citrate inhibits
A
PFK-1
6
Q
pyruvate kinase ATP inhibition is overcome by
A
fructose 1,6 bp
7
Q
PFK-1 ATP inhibition is overcome by
A
fructose 2,6 bp
8
Q
substrates needed for gluconeogenesis
A
lactate, alanine, glutamine, NAD+, glycerol
9
Q
besides ATP, how is pyruvate kinase inhibited
A
glucagon sends pkA over to phosphorylate pyruvate kinase to make it inactive. (allows usage of PEP for gluconeogenesis)
