glycogen storage Flashcards
in the liver, glycogenolysis is regulated by
hormones, ( by muscle contraction in skeletal muscles)
stimulates glycogenolysis
epi
largest amount of glycogen is found
in skeletal muscle. ( liver has highest concentration)
highly activated form of glucose which is used for glycogen synthesis
UDP glucose
UDP glucose is made from
glucose 1p and UTP
makes alpha 1-4 bonds
glycogen synthase
glycogen synthase is activated by
glucose 6p (inhibits glycogen phosphorylase)
andersons disease
defective 4:6 glucosydyltransferase (type IV) liver cirrhosis, death by 5 years.
cori disease
defective 4:4 glucosydyltransferase, type III
liver phosphorylase deficiency
Her’s disease. type VI, hepatomegaly
muscle phosphorylase deficiency
McArdle. type V, exercise induced cramps, rhabdo, brown urine, renal failure.