regulation of food intake Flashcards
1
Q
where are the neuronal centers that control feeding and satiety?
A
hypothalamus
2
Q
where does most of the integration signaling regulating food intake and energy expenditure happen?
A
arcuate nucleus
3
Q
described the anorexigenic pathway
A
POMC releases alpha-MSH which bind to MCR-4 in second order neurons
-inhibits feeding behavior
4
Q
what hormones are part of anorexigenic pathway?
A
- insulin
- leptin
- CCK
5
Q
describe the orexigenic pathway
A
- hunger signals stimulate NPY release
- binds to Y1R
- AGRP also released= antagonist of MCR-4
6
Q
what hormones are part of the orexigenic pathway?
A
-ghrelin
7
Q
what are good candidates for obesity therapy?
A
GLP-1,
oxyntomodulin,
leptin*, & peptide YY
8
Q
what has been shown to be elevated after RYGB
A
- GLP-1, PYY, proteobacteria
- increase insulin release
- increase gastric emptying
9
Q
what hormone changes are found with anorexia nervosa?
A
- decrease leptin
- decrease TSH
- decrease FSH, LH
- increase PYY
- increase Ghrelin (ghrelin resistance)
- increase coritsol
