Regulation of Animal Cell Shape Flashcards

1
Q

what are Cytoskeleton

A
  • Helps maintain cell shape
  • helps position the organelles within the cells
  • it rapidly disassembles and reassembles
  • allows for rapid changes in cell shape
  • is highly dynamic but still provides stability
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2
Q

what are the 4 main components of the cytoskeleton

A
  • microtubules (25nm)
  • Microfilaments (7nm)
  • intermediate filaments (8-12nm)
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3
Q

what are microtubules

A
  • are composed of tubulin subunits
  • have alpha and beta particles
  • resists compression, resulting in helping maintain the cell shape
  • they may radiate out from an organizing center
  • can also provide cell motility
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4
Q

what are the names of the 2 motions

A

1) flagella: ‘snake-like’ motion (sperm)

2) cilia: ‘rowing-like’ motion

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5
Q

if the cell are fixed in place what makes them move

A
  • cilia moves the fluid past them through beatings
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6
Q

microtubules are also involved in what other motility within the cell

A
  • organelle motility
  • ATP-powered motor proteins can ‘walk’ organelles along microtubules
  • allows vesicles, or other organelles to be transported to specific targets within the cell
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7
Q

what are microfilimants

A
  • are double chain of actin subunits
  • they form linear strands, and 3-d networks (using branching proteins)
  • resist tension
  • the cortical network under the plasma membrane helps make this region less fluid and this maintains the cell shape
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8
Q

what interactions between actin support cell movement

A
  • motor proteins –> myosin
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9
Q

what does actin-myosin interactions allow

A
  • muscle contraction
    amoeboid movement
    cytoplasmic streaming in plants
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10
Q

what are intermediate filaments made of

A

made of various proteins: keratins, lamins, neurofilaments

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11
Q

describe intermediate filaments (what they look like etc)

A
  • supercoiled into ‘cables’
  • less dynamic than microtubules or microfilaments
  • they form relatively permanent cellular structure
  • good at resisting tension
  • they may also remain after the cell that made them has died, e.g hair and out layer of skin
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12
Q

what do intermediate filament help with

A
  • maintaining cell shape

- anchoring organelles

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13
Q

what are the 3 major types of cell junctions

A
  • tight
  • desmosomes
  • gap
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14
Q

describe the tight junctions

A
  • hold neighboring cells tightly pressed together
  • may form a continuous seal
  • prevents movement of fluid across cell layers
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15
Q

describe desmosomes

A
  • anchoring junction
  • provide attachment between sheets if cells
  • act like rivets
  • connected into the cell by intermediate filaments
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16
Q

describe what a gap junction is

A
  • a point of cytoplasmic contact between 2 cells
  • ions and small molecules can pass from cell to cell
  • allows rapid cell to cell (intercellular) communication
17
Q

how are cell joined together

A
  • the extracellular matrix
18
Q

describe the extracellular matrix

A
  • the ECM is composed of material secreted by cells
  • this secretion occurs by constitutive exocytosis
  • most ECM proteins are glycoproteins
19
Q

what are most abundant ECM glycoprotein called

A
  • is collagen

- collagen fibres have great tensile strength

20
Q

where do you find the collagen fibres

A
  • are embedded in a proteoglycan complex matrix
21
Q

what are proteoglycans, and what do they do

A
  • are proteins with extensive sugar additions
  • they trap water within the ECM
  • water resists compression and thus helps retains tissue shape
22
Q

what other glycoproteins attach cells to the ECM

A
  • Fibronectins
23
Q

what membrane proteins connect the ECM to the cytoskeleton

A
  • Integrins
24
Q

what does the fibronectins and integrins provide from the ECM to the cell interior

A
  • a communication link from ECM to the cell interior