regional Flashcards
what nerve layer encapsulates individual neurons
endoneurium
what nerve layer is tough and contains several neruons
perineum
what nerve layer is the toughest for local anesthetics to cross
perineurim
what is the nerve layer that is outermost and protects several groups of perineurium, essentially the sheath
epineurium
T/F a nerve will heal if you cut through it
F
are smaller or larger nerves blocked first
smaller
are myelinated or unmyelinated nerves blocked first
myelinated
why are C fibers resistant to LA
they are unmyelinated
where does LA pool
near axonal membrane/ nodes of ranvier
what nerve types are the aim for blocks
A delta- pain
A beta-muscle
what is the order of nerve block onset
B,
A delta,
A gamma,
A beta,
A alpha,
C
what is the order of nerve recovery
C,
A delta,
A gamma,
A beta,
A alpha,
what do A-alpha nerves transmit
muscle length, force, propioception
what do A-beta nerves transmit
proprioception, touch, pressure
what do A-gamma nerves transmit
skeletal muscle tone
what do A-delta nerves transmit
pain, temp, touch
what do B nerves transmit
autonomic fxn
what do sC nerves transmit
autonomic fxn
what do dC nerves transmit
pain, temp, temp, touch, autonomic fxn
what is the action of local anesthetics
impair propagation of the AP along nerve axon
direct action on voltage-gated sodium channels to prevent sodium influx
the __________ form of the LA penetrates the libip bilayer of the nerve
non-ionized
the ________ form of the LA locks the sodium channel
ionized
what can you add to LA to increase onset
HCO3, makes in more non-ionized
what happens to the non-ionized LA that crosses over into the nerve
becomes ionized
what does pKa correlate with
onset
the ____________ the pKa the more non-ionized and the ________ the onset
lower (pH)
faster
local anesthetics are weak (acids/bases_
bases
pKa chart
tetracaine Pka onset and %nonionized @ ph 7.4
pka 8.6
% non ionized 14
slow onset
bupivicaine Pka onset and %nonionized @ ph 7.4
pka 8.1
non ionized 17
moderate onset
ropivicaine Pka onset and %nonionized @ ph 7.4
pka 8.1
% nonionized 17
moderate onset
chloroprocaine Pka onset and %nonionized @ ph 7.4
pka 9.1
% nonionized 2
fast onset