Regeneration & Repair Flashcards
1
Q
How are damaged tissues restored?
A
- removal of exudate
- removal of cellular and tissue debris
- replacement of cells/tissue lost
2
Q
Labile cells
A
proliferate throughout life
epidermis, blood, uterine mucosa, glandular epithelium
3
Q
Stable cells
A
in G0 but can be recruited to G1
mesenchymal cells, viscera, hepatocytes, renal tubular cells
4
Q
Permanent cells
A
can’t divide post-nasally
neurons, cardiac muscle cells
5
Q
Components of ECM
A
- collagens
- glycosaminoglycans
- proteoglycans
- glycoproteins
- fibronectins (HMW glycoproteins)
6
Q
Where are fibronectins found?
A
- cell surfaces
- basal lamina
- percellular matrices
7
Q
How are fibronectins produced?
A
- fibroblasts
- endothelial cells
- monocytes
8
Q
Function of Fibronectin in Wound Healing
A
- glue-like effect for epithelium
- chemotactic for monocytes and fibroblasts
- stimulate endothelial migration and organization
- release bFGF (Fibroblast GF) from monocytes
