Causes of Disease Flashcards

1
Q

Define “disease”

A
  • pattern of response of living organisms to injury (when cells fail to adapt or the adaptive mechanism is harmful, disease results)
  • a result of physical/environmental insults (acquired) and/or genetic aberration (inherited/acquired)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

“Signs”

A
  • objectively measured/observed by doctor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

“Symptoms”

A
  • subjective complaints

- from patient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

“Morbidity”

A

impairment of well-being/normal functioning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

“Mortality”

A

death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Leading cause of death in both Canadian men and women?

A

Heart disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Leading cause of cancer death for both sexes?

A

Lung cancer**

** women’s mortality rates for lung cancer have doubled, while men have declined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe the trend for life expectancy

A
  • steadily increased

- females have always been a little higher

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

“Etiology”

A

cause of a disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

“Pathogenesis”

A

development of a disease

the mechanism of the disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

“Pathological and morphological manifestations”

A

changes in structure and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

“Complications and sequelae”

A

secondary consequences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

“Prognosis”

A

course of the disease + final outcome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

“Epidemiology”

A

study of disease in population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

“Incidence”

A

of new cases in a given population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

“Prevalence”

A

total # of cases in a population (new + old)

17
Q

Techniques of Pathology

A
  • gross examination
  • light microscopy
  • immunohistochemistry (+ immunofluorescence)
  • electron microscopy
  • molecule pathology (genes)
18
Q

“Genetic insults”

A
  • vary from single mutations to large chromosome rearrangements
  • congenital (at birth) or acquired
19
Q

Top causes of mortality in Canada

A
  1. cardiovascular
  2. cancer
  3. cerebrovascular disease
20
Q

Top causes of morbidity in Canada

A
  1. diseases of circulatory system
  2. GI disease
  3. Respiratory disease
21
Q

“idiopathic”

A

unknown etiology

22
Q

Examples of physical agents

A
  • mechanical trauma
  • temperature
  • electrical burns
  • radiation
  • atmospheric pressure
23
Q

Chemical Agents

A
  • environmental/industrial exposure

- poisons, toxins, pesticides, organic solvents, heavy metals, strong acids/bases, components in cigarette smoke

24
Q

“Iatrogenic disease”

A

adverse condition (unintended injuries/complications) occurring as the result of treatment by a health care professional

25
Q

Examples of Environmental Causes

A
  1. Physical
  2. Chemical
  3. Drugs
  4. Iatrogenic
  5. Infections
  6. Allergens
26
Q

Alternative Classifications of Diseases

A
  1. Injury
    • reversible or irreversible
  2. Inflammation
  3. Infection
  4. Immunological Reaction
    • protective, but may become excessive, absent/depressed, or against own body
  5. Neoplasia
    • benign or malignant
  6. Metabolic/Endocrine
    • disorders of enzymes, hormones, secretory products
  7. Nutritional
    • insufficient or excess
  8. Vascular Disease
  9. Psychological Factors
    • both cause and effect disease
27
Q

“Neoplasia”

A

autonomous proliferation of cells, causing tumours/masses