regeneration and repair

Question 1

outline the differences between bodily regeneration and bodily repair

Answer 1

resolution:
- initiating factor removed
- tissue undamaged or able to regenerate
repair:
- initiating factor still present
- tissue damaged and unable to regenerate

Question 2

describe the process of healing by first intention and outline the steps of this process.

Answer 2

• haemostasis - platelets and cytokines forms a haemotoma and causes vasoconstriction - limiting blood loss to the area
• the closed wound edges allow for easy clot formation
• inflammation - to remove any cell debris or pathogens
• proliferation - inflammatory cells release cytokines which cause fibroblasts to proliferate to form granulation tissue
• angiogenesis occurs (formation of blood vessels)
• fibroblasts produce collagen
• remodelling - collagen fibres deposited in the wound

Question 3

describe the process of healing by secondary intention and outline the steps of this process.

Answer 3

• haemostasis - a large fibrin mesh fills the wound
• inflammation - larger amount
• proliferation - granulation tissue forms at the bottom of the wound - once this grows and fills the wound, only then can the epithelia grow
• remodelling - would contraction may occur and inflammatory responce begins to resolve

Question 4

what is an important cell for wound contraction during secondary intention healing?

Answer 4

• myofibroblasts
• theyre modified smooth muscle cells
• contain actin and myosin
• also deposit collagen

Question 5

name the cells which can regenerate

Answer 5

• hepatocyes
• pneumocytes
• all blood cells
• gut epithelium
• skin epithelium
• osteocytes

Question 6

name the cells which cannot regenerate

Answer 6

• myocardial cells
• neurons