Regeneration

Question 1

Best material to get gain in zero wall defect

Answer 1

Autograft

70:30 FDBA/ DFDBA

Question 2

What about the decalcification in DFDBA promotes osteoinduction

Answer 2

only 2% or less residual calcium

This makes BMP available

Question 3

Which is better for osteogenesis cortical or cancellous bone

Answer 3

Cancellous due to haematopoetic marrow

Question 4

How is calcium sulphate resorbed

Answer 4

Giant cell reaction

Question 5

Advantage of bioresorbable membrane

Answer 5

Tissue compatable
No 2nd surgery
Regulated by amount of cross linking

Question 6

Which BMP in DFDBA

Answer 6

BMP - 2

Question 7

How does biogide degrade

Answer 7

Collagenase

Then Gelatiniase and peptidase

Question 8

What are collagen membranes made of

Answer 8

Porcine/ Bovine

Type I and Type III

Question 9

What determines is a wound repairs or regenerates

Answer 9

Cell type that repopulates

Mesenchyme - Regeneration

Question 10

How do you most accurately assess regeneration

Answer 10

Histopathology

Radiographic

Question 11

How does dense HA heal

Answer 11

Long JE and CT attachment

No new attachment

Question 12

What are progressive and competence factors

Answer 12

Competence: Prime cell to enter cell prolif cycle

Progression: Needed for cell division

Question 13

What is regeneration

Answer 13

Cementum
Bone
Functionally orientated PDL

Question 14

What is reattachment

Answer 14

Non Dx site

Question 15

What is repair

Answer 15

Long JE and CT - Scar

Question 16

What is a root conditioner

Answer 16

Remove smear layer
Expose collagen
Open tubules

Citric Acid, EDTA, Tetracycline

Question 17

what is osteogenic

Answer 17

Vital cells
Produce new bone
autograft
Amount of cancellous key

Question 18

What is osteoinductive

Answer 18

Induces bone formation by recruiting undiff mesenchymal cells that are mitogenic for pre osteoblast

DFDBA/FDBA

Question 19

What is osteoconductive

Answer 19

Scaffold for bone formation

Question 20

What is a xenograft

Answer 20

Different species
Scaffold
Osteoconductive

Question 21

What is alloplast

Answer 21

Inorganic material

Question 22

What is GTR

Answer 22

A barrier membrane allowing formation of new periodontium

Question 23

What are the available membrane types

Answer 23

Resorbable

Non Resorbable

Question 24

Positive of non resorbable membrane

Answer 24

Stiff

Question 25

Negative of non resorbable membrane

Answer 25

2nd surgery needed.

Question 26

Positive of resorbable membrane

Answer 26

No second surgery

Question 27

Negative of resorbable membrane

Answer 27

Lack stiffness

Question 28

Discuss emdogain

Answer 28

Osteopromotive: From developing porcine teeth, they mimic matrix proteins. Allow faster primary closure

Question 29

Discuss PDGF

Answer 29

Platelet derived growth factor | Mitogenic and chemotactic for mesenchymal cells

Question 30

What are BMP

Answer 30

Regulatory glycoproteins that stimulate mesenchymal stem cells differentiation to chondroblast and osteoblast. Risk of ankylosis

Question 31

What influences success of regen

Answer 31

``` Tooth type Defect Surgical management OH Compliance Smoking Keep cells out No infection ```

Question 32

How do resorbable membranes break down

Answer 32

Krebs Cycle

Question 33

What is the ideal material for ridge preservation

Answer 33

Osetoconductive

Question 34

What is the point of decalcification

Answer 34

Open marrow spaces and allow osteopromotive cells out

Question 35

What influences the osteoinductive potential of the graft

Answer 35

Age of the donor

Question 36

Why does regen fail

Answer 36

Mechanical Instability Poor blood supply Competing tissue

Question 37

When graft and bolt

Answer 37

Ridge 4 mm wide and primary stability

Question 38

Why do you get early membrane exposure

Answer 38

``` Not aseptic No passive closure Inadequate flap mobility Smoking Diabetis Pressure from prosthesis Shallow vestibule ```

Question 39

What bacteria colonize exposed membrane

Answer 39

P Ging | A Actino

Question 40

Bone resorption following XLA

Answer 40

40-60% horizontal in 3/12.

Question 41

What is PASS

Answer 41

Primary closure Angiogenesis Space Maintenance Stability

Question 42

What is the gain in a ridge split

Answer 42

3.5 mm

Question 43

How long auto/allo block grafts last

Answer 43

3/12

Question 44

How much vertical bone be gained

Answer 44

3 - 5 mm

Question 45

How do you obtain vertical augmentation

Answer 45

Onlay block Distraction Ortho Extrude