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Keeling Summer Textbook > Regeneration > Flashcards

Regeneration Flashcards

1
Q

Best material to get gain in zero wall defect

A

Autograft

70:30 FDBA/ DFDBA

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2
Q

What about the decalcification in DFDBA promotes osteoinduction

A

only 2% or less residual calcium

This makes BMP available

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3
Q

Which is better for osteogenesis cortical or cancellous bone

A

Cancellous due to haematopoetic marrow

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4
Q

How is calcium sulphate resorbed

A

Giant cell reaction

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5
Q

Advantage of bioresorbable membrane

A

Tissue compatable
No 2nd surgery
Regulated by amount of cross linking

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6
Q

Which BMP in DFDBA

A

BMP - 2

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7
Q

How does biogide degrade

A

Collagenase

Then Gelatiniase and peptidase

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8
Q

What are collagen membranes made of

A

Porcine/ Bovine

Type I and Type III

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9
Q

What determines is a wound repairs or regenerates

A

Cell type that repopulates

Mesenchyme - Regeneration

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10
Q

How do you most accurately assess regeneration

A

Histopathology

Radiographic

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11
Q

How does dense HA heal

A

Long JE and CT attachment

No new attachment

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12
Q

What are progressive and competence factors

A

Competence: Prime cell to enter cell prolif cycle

Progression: Needed for cell division

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13
Q

What is regeneration

A

Cementum
Bone
Functionally orientated PDL

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14
Q

What is reattachment

A

Non Dx site

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15
Q

What is repair

A

Long JE and CT - Scar

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16
Q

What is a root conditioner

A

Remove smear layer
Expose collagen
Open tubules

Citric Acid, EDTA, Tetracycline

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17
Q

what is osteogenic

A

Vital cells
Produce new bone
autograft
Amount of cancellous key

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18
Q

What is osteoinductive

A

Induces bone formation by recruiting undiff mesenchymal cells that are mitogenic for pre osteoblast

DFDBA/FDBA

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19
Q

What is osteoconductive

A

Scaffold for bone formation

20
Q

What is a xenograft

A

Different species
Scaffold
Osteoconductive

21
Q

What is alloplast

A

Inorganic material

22
Q

What is GTR

A

A barrier membrane allowing formation of new periodontium

23
Q

What are the available membrane types

A

Resorbable

Non Resorbable

24
Q

Positive of non resorbable membrane

A

Stiff

25
Q

Negative of non resorbable membrane

A

2nd surgery needed.

26
Q

Positive of resorbable membrane

A

No second surgery

27
Q

Negative of resorbable membrane

A

Lack stiffness

28
Q

Discuss emdogain

A

Osteopromotive: From developing porcine teeth, they mimic matrix proteins. Allow faster primary closure

29
Q

Discuss PDGF

A

Platelet derived growth factor

Mitogenic and chemotactic for mesenchymal cells

30
Q

What are BMP

A

Regulatory glycoproteins that stimulate mesenchymal stem cells differentiation to chondroblast and osteoblast.

Risk of ankylosis

31
Q

What influences success of regen

A 
Tooth type
Defect
Surgical management
OH
Compliance
Smoking
Keep cells out
No infection
32
Q

How do resorbable membranes break down

A

Krebs Cycle

33
Q

What is the ideal material for ridge preservation

A

Osetoconductive

34
Q

What is the point of decalcification

A

Open marrow spaces and allow osteopromotive cells out

35
Q

What influences the osteoinductive potential of the graft

A

Age of the donor

36
Q

Why does regen fail

A

Mechanical Instability
Poor blood supply
Competing tissue

37
Q

When graft and bolt

A

Ridge 4 mm wide and primary stability

38
Q

Why do you get early membrane exposure

A 
Not aseptic
No passive closure
Inadequate flap mobility
Smoking
Diabetis
Pressure from prosthesis
Shallow vestibule
39
Q

What bacteria colonize exposed membrane

A

P Ging

A Actino

40
Q

Bone resorption following XLA

A

40-60% horizontal in 3/12.

41
Q

What is PASS

A

Primary closure
Angiogenesis
Space Maintenance
Stability

42
Q

What is the gain in a ridge split

A

3.5 mm

43
Q

How long auto/allo block grafts last

A

3/12

44
Q

How much vertical bone be gained

A

3 - 5 mm

45
Q

How do you obtain vertical augmentation

A

Onlay block
Distraction
Ortho Extrude

Keeling Summer Textbook (11 decks)

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