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IHO Week 6 > Regal-Summary of actions of inflammation mediators > Flashcards

Regal-Summary of actions of inflammation mediators Flashcards

1
Q

What inflammatory mediators cause vasodilation–> redness?

A

Histmaine
PGE2
PGI2
kinins

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2
Q

What inflammatory mediators cause increased vascular permeability–> swelling?

A

Histamine
petido leukotrienes (LTC4, LTD4, LTE4)
kinins

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3
Q

What inflammatory mediators cause pain?

A

PGE
PGI
LTB4
Kinins

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4
Q

What inflammatory mediators are chemotactic (direct migrations of WBC)?

A

LTB4 (neutrophils)

petptidoleukotreines (eosinophils)

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5
Q

What inflammatory mediators cause fever?

A

PGEs

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6
Q

What inflammatory mediators cause airway constriction= bronchoconstriction?

A

Histamine
peptido leukotrienes
kinins
PGD2

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7
Q

What inflammatory mediators cause hypotension (shock)?

A

Kinins

Histamine

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8
Q

What does histamine do?

A 
redness
heat
swelling
airway constriction
NOT chemotaxis
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9
Q

What do PGE2 and PGI2 do?

A

Increase vascular permeability
vasodilate
cause pain

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10
Q

What do PGD2 and thromboxane do?

A

vasoconstriction

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11
Q

What does TXA2 do?

A

platelet aggregation

vasoconstriction

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12
Q

What does PGI2 do?

A

Oppose platelet aggregation

vasodilation

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13
Q

What does LTB4 do?

A

Chemotactic (PMNs)

reduces paint threshold

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14
Q

What do peptidoleukotrienes do?

A

bronchoconstriction
increased vascular permeability
chemotaxis

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15
Q

What do kinins do?

A

EVERYTHING

strong vasodilator–> HYPOTENSION

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IHO Week 6 (14 decks)

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