Diebel- Immunology Review

Question 1

What are the primary lymphoid organs?

Answer 1

BM

Thymus

Question 2

What happens in the primary lymphoid organs?

Answer 2

HSC differentiate into:

Lymphoid precursors>
DCs
B cell progenitors
Thymus> T cell precursors> CDR4 and CD8

Myeloid precursors>
granulocyte/monocyte pre
eosinophil pre
basophil pre
megakaryocyte pre
erythrocyte pre

Question 3

What are secondary lymphoid organs?

Answer 3

spleen
LN
malt

Question 4

What cells do you find in secondary lymphoid organs?

Answer 4

Mature B2 B cells

Th0–> Th1, Th2, Th17, T reg

CD8

Question 5

What do you find in the periphery?

Answer 5

DC
NK
Monocytes
Neutrophils
Eosinophils
Basophils
Platelets
RBCs

Question 6

What is the percentages of cells in the granulocyte series?

Answer 6

Monocytes 1-6%
Neutrophils 50-70 %
Eosinophils 1-3%
Basophils <1%

Question 7

CD2 marker

LFA-3 R

Answer 7

Adhesion molecule that facilitates co-stimulation (synapse w/ T cell and APC)

Th
Tc
NK

Question 8

CD3

Answer 8

TCR signaling

Th
Tc

Question 9

CD4

Answer 9

Binds to MHC II

Th

Question 10

CD5

Answer 10

?

B1-B cells
Th
Tc
NK

Question 11

CD8

Answer 11

MCH I

Tc

Question 12

CD16 is also known as…..

Answer 12

FcyRIII–causes Ab dependent cell mediated cytotoxicity (ITAM)

NK

Question 13

CD19

Answer 13

Signal transduction, often works w/ CD21

B cells

Question 14

CD21

CR2

Answer 14

Receptor for complement–binds CD3 fragment

Bcells

Question 15

CD28

Answer 15

Binds B7 during activation (can’t bind–> angergy)

Th
Tc

Question 16

CD32

Answer 16

FcyRII

B cells

Question 17

What are the two types of CD32 and what do they do?

Answer 17

a- phagocytoisis–> MCHII–> T cell help–> class switch recombination

b- blocks phagocytosis–> stimulation to become memory cells

Question 18

CD35

Answer 18

Receptor for complement, C3b fragments (CR1 receptor)

B cells

Question 19

CD40

Answer 19

Stim by CD4 T cells

B cells

Question 20

CD40L

Answer 20

Th

Tc