Reduced exocrine secretions Flashcards

1
Q

Exocrine Pancreatic insufficiency - This condition is characterised by

A

reduced secretion of pancreatic enzymes into the intestines.

  • As a result, symptoms include maldigestion and malnutrition associated with low circulating levels micronutrients. Patients also present with GI symptoms such as diarrhoea, abdominal cramps + steatorrhea.
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2
Q

Drug treatment

A

Pancreatic enzyme replacement therapy with Pancreatin. Pancreatin contains 3 groups of digestive enzymes: lipase, amylase and protease. These enzymes digest fat, carbohydrates and proteins!

 The drug must be administered with meals and snacks. if mixed with food or drink - do not keep for over 1 h.

  • adequate hydration when using high strength pancreatin
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3
Q

Pancreatin inactivated by….

A
  • Do not mix with excessively hot food or drinks as it pancreatin is inactivated by heat
  • Eat with meals as pancreatin inactivated by gastric acid
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4
Q

SE

A
  • GI SE common
  • irritation - perioral skin and buccal mucosa
  • fibrosing colonopathy in cystic fibrosis with high doses
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