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HEMA 1: LAB > Red Cell Indices > Flashcards

Red Cell Indices Flashcards

1
Q

In 1929, Wintrobe introduced mathematical way of determining the average size, hemoglobin content, and concentration of red blood cells.

These are the erythrocyte indices, or….

A

RBC indices

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2
Q

RBC indices

These parameters are calculated from (3). To date, the RBC indices have been useful in the morphologic characterization of anemia.

A

red cell count, hemoglobin, and hematocrit

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3
Q

In addition, it also serves as a quality control check of hematology analyzers.

A

RBC indices

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4
Q

The RBC Indices are:

A
  1. Mean Cell Volume (MCV)
  2. Mean Cell Hemogicbin (MCH)
  3. Mean Cell Hemoglobin Concentration (MCHC)
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5
Q

Also known as mean corpuscular volume, the MCV

reflects the average volume of a red cell, which is also reflective of its average size.

A

Mean cell volume

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6
Q

It is expressed in femtoliters (fL) or 10-15L.

A

Mean cell volume

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7
Q

MCV

reference

A

80-100 fL

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8
Q

MCH

cell ref

A

26-32 pg

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9
Q

MCHC

Reference range

A

32-36 g/dL

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10
Q

Related to the size RBC

A

Mean Cel Volume (MCV)

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11
Q
  • Average volume of RBC in a given sample
A

Mean Cell Volume (MCV)

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12
Q

• Related to the color of RBCs when examined under the microscope

A

Mean Cell Hemoglobin (MCH)

Mean Cell Hemoglobin Concentration (MCHC)

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13
Q

• Average content (weight) of hemoglobig in a single RBC

A

Mean Cell Hemoglobin (MCH)

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14
Q

Average conc of hemoglobin in a unit volume of RBCs in a sample

A

Mean cell hemoglobin concentration

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15
Q

is helpful in classifying anemias based on size.

A

MCV

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16
Q

MCV: Causes of spurious increase

A

Autoagglutination
High WEC (>50,000/uL)
Hyperglycemia
Reduced red cell deformability

17
Q

MCV: Causes of spurious decrease

A

Cryoglobulin
Cryofibrinogen
Giant platelets
Hemolysis (in vitro)
Microcytic red cell
Swollen red cell

18
Q

, is a measure of the content (weight) of hemoglobin per red cell.

A

MEAN CELL HEMOGLOBIN (MCH)

19
Q

It is directly proportional to the amount of hemoglobin and the size of the REC. it is expressed in picograms, or 10-12 pg

A

MCH

20
Q

However, generally,____ is not considered in the classification of anemias.

A

MCH

21
Q

Clinica/ Significance

In anemias due to impaired hemoglobin production, such as thalassemia and iron deficiency anemia, the hemoglobin mass per RBC decreases.

A

Mean Cell Hemoglobin

22
Q

Sources of Errors in MCH Measurement
Causes of spurious increase

A

Hyperlipidemia
Plasma Turbidity

23
Q

It is expressed as grams per deciliter (formerly expressed as percentage).

A

MEAN CELL HEMOGLOBIN CONCENTRATION (MCHC)

24
Q

It can also be defined as the ratio of the weight of the hemoglobin to the volume of red cells.

A

MEAN CELL HEMOGLOBIN CONCENTRATION (MCHC)

25
Q

Also known as …, it is the average concentration of hemoglobin in a given volume of packed red cells.

A

MEAN CELL HEMOGLOBIN CONCENTRATION (MCHC)

26
Q

MCHC: Causes of spurious increase

A

Auto agglutination
Clotting
Hemolysis (in vitro/vivo)
Spuriously high Hb or low/ HCT

27
Q

MCHC: Causes of spurious decrease

A

High WBC (>50, 000/uL)
Spuriously low Hb
Spuriously high HCT

28
Q

The________ is a red cell numerical parameter that reflects the heterogeneity of red cell volume (or size) in a given sample.

A

red cell distribution width

29
Q

It has been suggested that_____ can be used as an early indicator for classifying anemia, as it tends to deviate from normal levels earlier in nutritional deficiency anemias compared to other red cell parameters, particularly in cases of iron deficiency anemia.

A

MCHC

30
Q

The______ is a valuable parameter for characterizing microcytic anemias.

It plays a crucial role in distinguishing between different types of anemias, especially when trying to differentiate uncomplicated iron deficiency anemia and uncomplicated heterozygous thalassemia.

A

RDW (Red Cell Distribution Width)

31
Q

• Autoagglutination

A

Increase MCV

32
Q

• Hyperosmolar State

A

Increase MCV

33
Q

• Old Specimen

A

Increase MCV

34
Q

• Autoagglutination

A

• False increase of MCH and
MCHC

35
Q

• Turbid Plasma

A

• False increase of MCH and
MCHC

36
Q

Microcytic

> 80 fL

A

Thalassemia
Anemia of chronic disease
Iron deficiency anemia
Lead poisoning
Sideroblastic anemia

37
Q

Macrocytic

> 100 fL

A

Megaloblastic
- vitB12 deficiency
- folate deficiency

Non-Megaloblastic
- aplastic anemia
- chromic liver disease
- alcoholism

HEMA 1: LAB (12 decks)

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