Red blood Cells In General Flashcards
The one who is first to describe RBCs as “small globules”
Anton van Leeuwenhoek
Differentiate erythron from RBC mass
RBC mass- includes RBCs only in the circulation
Erythron - includes RBCs in the BM and circulation
In what gene is erythropoietin found
Chromosome 7
Reference range of EPO
5-30 mU/MI
How does the liver function in destruction and death of RBCs
The liver removes damaged RBCs FROM THE CIRCULATION
Function of Spleen in RBCs death/destruction
The spleen is the principal site for senescent RBCs
Basic nutrient requirement of RBCs
Iron, folate, vit B12
Fill in the blank
Pernicious anemia is a _____ anemia which is caused by a _______ ______factor.
megaloblastic, defective, intrinsic
In what conditions is erythropoiesis usually initiated
In HYPOXIC CONDITIONS like high altitudes, decreased RBC count, decreased availability of Oxygen, or increased tissue demand for Oxygen
Sites of bone marrow in the body
Sternum, pelvis (iliac crest), proximal end of long bones, skull, ribs, vertebrae
The earliest committed RBC progenitor
BFU- E
It stimulates maturation of BFU- into CFU-E
KIT ligands (IL3, TPO, G-CSF)
Recall the difference between progenitor and precursor
Progenitors: all are similar/cannot be differentiated
Precursor: starts to differentiate
[RBC precursor] Globin production starts at this stage
Rubriblast/Pronormoblast/Proerythroblast
[RBC precursor] There is detectable hemoglobin synthesis
Prorubricyte/Basophilic normoblast/basophilic erythroblast
[RBC precursor] The last stage capable of mitosis
Rubricyte/ Polychromatic normoblast/Polychromatic erythroblast
[RBC precursor] Where the nucleus is ejected
Metarubricyte/Orthochromic normoblast/Orthochromatophilic normoblast
[RBC precursor] Hemoglobin production is completed; contains nucleus
Reticulocyte/ Polychromatic erythrocyte
[Color] Anisochromasia
Unequal distribution of Hgb in the cell
[Color] Polychromatophilia / polychromasia
Multiple-colored
Seen in Wright stain
What are shift erythrocytes?
Premature release of erythrocytes from bone marrow
What is the expected MCV and MCHC value in cases of spherocytosis
Normal MCV
Increased MCHC
4 Basic Functions of RBC membrane
- Separates intra and extracellular fluid environment of plasma
- Allows ion and nutrient passage
- Allows cell to deform when required
- Acts as supporting cells for antigens and receptors
Composition of RBC
(Rodaks)
Protein: 52%
Lipids: 40%
Carbs: 8%
(Others)
Protein: 50%
Lipids: 40%
Carbs: 10%
Fucntions of peripheral proteins
Regulate shape and deformability
Examples of peripheral proteins and asscoc dse
Spectrin band 1 and 2 ( hereditary elliptocytosis and heredity spherocytosis)
Actin band 5
Function of integral proteins
Resposible for zeta potential
GP band 3 function
Sn inorganic transport protein which
Gives the red cell a negative charge
Enzyme Systems of RBC
Na-K pump
Calcium pump
Na- K pump involves what
Active transport
Sodium is expelled
Potassium is absorbed inside the cell
Too much intake of potassium will cause SHRINKAGE
Too much intake of sodium will cause SWELLING/LYSIS
Calcium pump involves what
Calcium goes out of the cell
Calcium inside the cell prevents cell deformability
Magnesium goes inside of the cell
Too much calcium makes cell RIGID and LESS DEFORMABLE
