Recovery of Function Flashcards
What is plasticity?
The ability to show modification especially in nervous tissue
What are the three mechanisms of neuroplasticity?
- Collateral sprouting
- Functional reorganization
- Neuronal regeneration
What is the process of collateral sprouting?
- New connections are formed via axonal sprouting and the brain continues to make new neurons
- Pruning can occur which is when connections that are used frequently become stronger over time
What is functional reorganization?
- Process by which one area of the brain can take over for function lost in another area
- Occurs more often in children than adults
What is neuronal regeneration?
Process of synaptic plasticity that involves experience-dependent long-lasting changes in the strength of neuronal connections
What is long term potentiation?
A type of synaptic plasticity where the threshold needed to stimulate the pre-synaptic neuron lowers which enhances the synapse
Under what two conditions does plasticity occur?
- Typical development and learning
- Recovery of function following neural pathology
True or False
Plasticity is a two-way street, so changes can be positive or negative
True
Activity leads to positive changes, inactivity leads to negative changes (use it or lose it)
What is recovery?
- Restore function to tissue lost in injury
- Restoring the ability to perform movement in the same manner as before the injury
- Task accomplished in the same way, using the same structures
What is compensation?
- Neural tissue acquires a function it did not have prior to injury
- Perform an old movement in a new way
- Task accomplished using alternate structures (AD)
List the factors that affect recovery of function?
- Age
- Extent/characteristics of lesion
- Pre-injury factors
- Post-injury factors
How does age impact recovery of function?
- If injured area is already mature, the injury will likely cause damage
- If injured area is not yet mature, then a second immature area can take over function
How do the characteristics of a lesion impact recovery of function?
- Greater functional loss with a larger lesion compared to a smaller lesion
- Slowly developing lesions cause less functional loss than a quickly developing lesion
How can pre-injury factors impact recovery of function?
- Exercise can induce neuroplasticity, oxygenate the brain, decrease apoptosis, decrease edema, and decrease inhibition of neurite growth inhibiting molecules
- Full, active, and varied environmental enrichment can allow for greater ability to reorganize
- Diet/nutrition
How can post-injury factors impact recovery of function?
- Neurotrophic factors such as nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) can be involved in neural survival and plasticity
- Some medications can enhance or replace neurotransmitters and restore blood circulation, others can negatively affect recovery
- Exercise can help recovery