Receptors short answer Flashcards

1
Q

Which receptor stimulates gluconeogenesis & glycogenolysis in the Liver

A

B2

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2
Q

What receptor stimulates glycogenolysis in the liver

A

A1

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3
Q

Which receptor stimulates insulin secretion in the pancreas

A

B2

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4
Q

Which receptor inhibit insulin release in the pancreas

A

A2

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5
Q

What receptor stimulates lipolysis in adipose

A

B3

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6
Q

What receptor inhibit lipolysis in the adipose

A

A2

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7
Q

What receptor stimulates glycogenolysis, gluconeogenisis in skm

A

B2

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8
Q

A1
receptor
increases/decreases what
main physiological effect

A

Gq-increased intracellular calcium- vasoconstriction& mydriasis

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9
Q

A2
receptor
increases/decreases what
main physiological effect

A

Gi-decreased camp, K efflux and decreased calcium, decreased norepi release(autoreceptor), decreased ACH, decreased heart rate,
decreased SNS=increased vagal tone, decreased NT release

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10
Q

B1
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increase calcium influx, increased heart conduction, rate, and contractility

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11
Q

B2
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increased pka, decreased MLCK, bronchodilation -vasodilation-inhibits release of inflammatory mediators

some B2 on myocardium SA node

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12
Q

B3
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increased pka, bladder detrusor relaxation

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13
Q

D1

A

D1
Gs-decreased MLCK, renal vascular smooth muscle relaxation
vasodilation in kidney, intestine, heart

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14
Q

D2

A

D2
“think A2”
Gi-decreased camp, K efflux and decreased calcium
presynaptic-decreased sympathetic release-decreased norepi release
post synaptic-vasoconstriction

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15
Q

M3

A

Gq-increased calcium-PSNS activation-bronchoconstriction-BB Sludge

extra junctional M3 on bladder stimulated by NO-contract detrusor
extra junctional M3 vasodilation simulated by NO
NO relax smooth muscle relaxation, relaxes internal urethral, raises the Ol point and shoot

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16
Q

M2

A

“The opposite B1” (negative Bancy)
Gi-decreased camp, K efflux and decreased calcium –decreased heart rate (sa and av) and contractility
-negative inotropic, dromotropic ,chronotropic effect on heart

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17
Q

Which receptor increased renin?

18
Q

Which receptor decreased uterine tone?

19
Q

What does EPI stimulating B1 on cardiac muscle cause phosphorylation of? result in ?

A

Troponin 1, contraction

20
Q

Troponin 1 is absent in smooth muscle so what happens in smooth muscle in regards to EPI and B2?

A

PKA phosphorylation of MLCK, inhibits myosin function, relaxation

21
Q

Beta2 in the lung is

A

extra-junctional (hormone) no nerve

EPI

22
Q

Name two extra junctional receptors?

A

B2,B3

B2 is presynaptic myocardium

23
Q

what receptor(s) causes venoconstriction?

24
Q

What receptor causes arteriolar constriction?

25
Presynaptic A2 receptors cause ________while post synaptic causes___________.
vasodilation | constriction
26
Why does presynaptic A2 cause vasoconstriction?
Inhibition of norepinephrine release
27
B2 relaxes what 4 things?
blood vessels, tracheal and bronchial muscles, uterus
28
What cause carbohydrate metabolism?
B2
29
D2 acts like what other receptor?
A2
30
D1 acts like what other receptor?
B2
31
Adipose B1?
lipolysis
32
What two receptors decrease renin secretion?
A1 D1
33
What receptor increase ADH secretion?
B1
34
Which presynaptic receptor stimulates NE release?
B2
35
name adrenergic presynaptic receptors
A2, B2 (heart), D2
36
Name adrenergic extra-junctional | found where?
a 2 and b 2 | vascular smooth muscle, platelets
37
presynaptic b2 does what
stimulates norepi release
38
presynaptic a2 does what
inhibits norepi release
39
NE has a low affinity for these 2 receptors
b2 and b3
40
cutaneous blood vessels are exclusively
a1