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PHARM 4 ANS > Receptors short answer > Flashcards

Receptors short answer Flashcards

1
Q

Which receptor stimulates gluconeogenesis & glycogenolysis in the Liver

A

B2

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2
Q

What receptor stimulates glycogenolysis in the liver

A

A1

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3
Q

Which receptor stimulates insulin secretion in the pancreas

A

B2

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4
Q

Which receptor inhibit insulin release in the pancreas

A

A2

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5
Q

What receptor stimulates lipolysis in adipose

A

B3

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6
Q

What receptor inhibit lipolysis in the adipose

A

A2

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7
Q

What receptor stimulates glycogenolysis, gluconeogenisis in skm

A

B2

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8
Q

A1
receptor
increases/decreases what
main physiological effect

A

Gq-increased intracellular calcium- vasoconstriction& mydriasis

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9
Q

A2
receptor
increases/decreases what
main physiological effect

A

Gi-decreased camp, K efflux and decreased calcium, decreased norepi release(autoreceptor), decreased ACH, decreased heart rate,
decreased SNS=increased vagal tone, decreased NT release

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10
Q

B1
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increase calcium influx, increased heart conduction, rate, and contractility

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11
Q

B2
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increased pka, decreased MLCK, bronchodilation -vasodilation-inhibits release of inflammatory mediators

some B2 on myocardium SA node

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12
Q

B3
receptor
increases/decreases what
main physiological effect

A

Gs-increased camp, increased pka, bladder detrusor relaxation

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13
Q

D1

A

D1
Gs-decreased MLCK, renal vascular smooth muscle relaxation
vasodilation in kidney, intestine, heart

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14
Q

D2

A

D2
“think A2”
Gi-decreased camp, K efflux and decreased calcium
presynaptic-decreased sympathetic release-decreased norepi release
post synaptic-vasoconstriction

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15
Q

M3

A

Gq-increased calcium-PSNS activation-bronchoconstriction-BB Sludge

extra junctional M3 on bladder stimulated by NO-contract detrusor
extra junctional M3 vasodilation simulated by NO
NO relax smooth muscle relaxation, relaxes internal urethral, raises the Ol point and shoot

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16
Q

M2

A

“The opposite B1” (negative Bancy)
Gi-decreased camp, K efflux and decreased calcium –decreased heart rate (sa and av) and contractility
-negative inotropic, dromotropic ,chronotropic effect on heart

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17
Q

Which receptor increased renin?

A

B1

18
Q

Which receptor decreased uterine tone?

A

B2

19
Q

What does EPI stimulating B1 on cardiac muscle cause phosphorylation of? result in ?

A

Troponin 1, contraction

20
Q

Troponin 1 is absent in smooth muscle so what happens in smooth muscle in regards to EPI and B2?

A

PKA phosphorylation of MLCK, inhibits myosin function, relaxation

21
Q

Beta2 in the lung is

A

extra-junctional (hormone) no nerve

EPI

22
Q

Name two extra junctional receptors?

A

B2,B3

B2 is presynaptic myocardium

23
Q

what receptor(s) causes venoconstriction?

A

A1&A2

24
Q

What receptor causes arteriolar constriction?

A

A1

25
Q

Presynaptic A2 receptors cause ________while post synaptic causes___________.

A

vasodilation

constriction

26
Q

Why does presynaptic A2 cause vasoconstriction?

A

Inhibition of norepinephrine release

27
Q

B2 relaxes what 4 things?

A

blood vessels, tracheal and bronchial muscles, uterus

28
Q

What cause carbohydrate metabolism?

A

B2

29
Q

D2 acts like what other receptor?

A

A2

30
Q

D1 acts like what other receptor?

A

B2

31
Q

Adipose B1?

A

lipolysis

32
Q

What two receptors decrease renin secretion?

A

A1 D1

33
Q

What receptor increase ADH secretion?

A

B1

34
Q

Which presynaptic receptor stimulates NE release?

A

B2

35
Q

name adrenergic presynaptic receptors

A

A2, B2 (heart), D2

36
Q

Name adrenergic extra-junctional

found where?

A

a 2 and b 2

vascular smooth muscle, platelets

37
Q

presynaptic b2 does what

A

stimulates norepi release

38
Q

presynaptic a2 does what

A

inhibits norepi release

39
Q

NE has a low affinity for these 2 receptors

A

b2 and b3

40
Q

cutaneous blood vessels are exclusively

A

a1

PHARM 4 ANS (6 decks)

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