Receptors short answer Flashcards
Which receptor stimulates gluconeogenesis & glycogenolysis in the Liver
B2
What receptor stimulates glycogenolysis in the liver
A1
Which receptor stimulates insulin secretion in the pancreas
B2
Which receptor inhibit insulin release in the pancreas
A2
What receptor stimulates lipolysis in adipose
B3
What receptor inhibit lipolysis in the adipose
A2
What receptor stimulates glycogenolysis, gluconeogenisis in skm
B2
A1
receptor
increases/decreases what
main physiological effect
Gq-increased intracellular calcium- vasoconstriction& mydriasis
A2
receptor
increases/decreases what
main physiological effect
Gi-decreased camp, K efflux and decreased calcium, decreased norepi release(autoreceptor), decreased ACH, decreased heart rate,
decreased SNS=increased vagal tone, decreased NT release
B1
receptor
increases/decreases what
main physiological effect
Gs-increased camp, increase calcium influx, increased heart conduction, rate, and contractility
B2
receptor
increases/decreases what
main physiological effect
Gs-increased camp, increased pka, decreased MLCK, bronchodilation -vasodilation-inhibits release of inflammatory mediators
some B2 on myocardium SA node
B3
receptor
increases/decreases what
main physiological effect
Gs-increased camp, increased pka, bladder detrusor relaxation
D1
D1
Gs-decreased MLCK, renal vascular smooth muscle relaxation
vasodilation in kidney, intestine, heart
D2
D2
“think A2”
Gi-decreased camp, K efflux and decreased calcium
presynaptic-decreased sympathetic release-decreased norepi release
post synaptic-vasoconstriction
M3
Gq-increased calcium-PSNS activation-bronchoconstriction-BB Sludge
extra junctional M3 on bladder stimulated by NO-contract detrusor
extra junctional M3 vasodilation simulated by NO
NO relax smooth muscle relaxation, relaxes internal urethral, raises the Ol point and shoot
M2
“The opposite B1” (negative Bancy)
Gi-decreased camp, K efflux and decreased calcium –decreased heart rate (sa and av) and contractility
-negative inotropic, dromotropic ,chronotropic effect on heart
Which receptor increased renin?
B1
Which receptor decreased uterine tone?
B2
What does EPI stimulating B1 on cardiac muscle cause phosphorylation of? result in ?
Troponin 1, contraction
Troponin 1 is absent in smooth muscle so what happens in smooth muscle in regards to EPI and B2?
PKA phosphorylation of MLCK, inhibits myosin function, relaxation
Beta2 in the lung is
extra-junctional (hormone) no nerve
EPI
Name two extra junctional receptors?
B2,B3
B2 is presynaptic myocardium
what receptor(s) causes venoconstriction?
A1&A2
What receptor causes arteriolar constriction?
A1
Presynaptic A2 receptors cause ________while post synaptic causes___________.
vasodilation
constriction
Why does presynaptic A2 cause vasoconstriction?
Inhibition of norepinephrine release
B2 relaxes what 4 things?
blood vessels, tracheal and bronchial muscles, uterus
What cause carbohydrate metabolism?
B2
D2 acts like what other receptor?
A2
D1 acts like what other receptor?
B2
Adipose B1?
lipolysis
What two receptors decrease renin secretion?
A1 D1
What receptor increase ADH secretion?
B1
Which presynaptic receptor stimulates NE release?
B2
name adrenergic presynaptic receptors
A2, B2 (heart), D2
Name adrenergic extra-junctional
found where?
a 2 and b 2
vascular smooth muscle, platelets
presynaptic b2 does what
stimulates norepi release
presynaptic a2 does what
inhibits norepi release
NE has a low affinity for these 2 receptors
b2 and b3
cutaneous blood vessels are exclusively
a1
