Rabbit hole shit/Receptor type/in-depth explanation/organ effect Flashcards
A1
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect 4
A1-Gq: postsynaptic : increased calcium
location/effect: vascular smooth muscle/Vasoconstriction
location/effect: iris/contraction/Mydriasis(dilation of pupil)
location/effect: liver/glycogenolysis
location/effect: bladder/contracts internal urethral sphincter
location/effect: heart-positive ionotropic in heart failure
A2
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
A2-Gi: postsynaptic & Presynaptic
He said focus here for our purposes/anesthesia
Presynaptic;
location/effect: presynaptic/postganglionic-negative feedback
-inhibit NE release, decreased norepi at autoreceptor,
-reduced NE reduces post synaptic a1 stimulation
-less post synaptic a1=less calcium calmodulin stim=less MLCK=relaxation
-decreased camp, potassium efflux, decreased calcium influx
-decreased heart rate
-indirectly causes vasodilation
location/effect: medulla-decreased SNS and increased vagal simulation, inhits NT relase=decreased CNS activity
postsynaptic/extra junctional;
location/effect: vascular smooth muscle/vasoconstriction
location/effect: pancreas-inhibits insulin secretion
location/effect: heart-decreased heart rate, explanation above
location/effect: adipose tissue: inhibits lipolysis
location effect: platelet aggregation
-post synaptic vasoconstriction explanation- decreased camp, decreased Pka, increased MLCK, little vasoconstriction (veins) , k channels closed
B1
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
B1-Gs postsynaptic
location/effect: heart/myocardium-increased contractility(inotropy), automaticity(chronotropy), conduction velocity(dromotropy)
location/effect: kidney juxtaglomerular cells-increased renin release, increased ADH
- increased camp, increase calcium influx
- increased heart rate( troponin 1)
- increased conduction
- increased myocardial contractility
- ↑heart rate and contractility, myocardium
B2
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
presynaptic: 1
postsynaptic: 6
B2-Gs postsynaptic & Presynaptic
presynaptic;
location/effect: myocardium-positive feedback for
adrenergic neuron, increased norepi release
postsynaptic:
location/effect: heart-coronary vessel dilation
location/effect: lungs-bronchodilation, suppress mast cell release of vasoactive mediators histamine, leukotrienes
location/effect: vascular smooth muscle-dilation
location/effect: SKM-increase k uptake, glycogenolysis
location/effect :Liver-glycogenolysis and gluconeogenesis
location/effect: pancreas-increase insulin secretion
increased camp, increased pka, decreased MLCK, vasodilation
B3
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
B3-Gs postsynaptic
location/effect: bladder-Relax bladder smooth muscle (detrusor) during bladder filling
location/effect: adipose-lipolysis
location/effect: ↓uterine tone
-increased camp
-vasodilation, bronchodilation, ↓uterine tone, glycolysis,
glycogenolysis, gluconeogenesis
D1
- Which receptor? What happens due to receptor binding?
- location/organ and effect
D1-Gs
location/effect: kidney and intestine-vasodilation
-decreased MLCK, vasodilate
D2
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
D2-Gi presynaptic
-decrease norepi and NT release.
-↓sympathetic release
M1
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
M1-Gq
location/effect: postganglionic cell body like Nn
-increased calcium release
-smooth muscle contraction, glandular secretion
postganglionic neurons
CNS, gastric parietal cells
M2
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
M2-Gi
location/effect: presynaptic nerve terminal(inhibitory autoreceptor)-decreased norepi and decreased ACH release
location/effect: atria myocardium, Sa, AV node-↓heart rate, ↓atrial contractility, decreased inotropy
-k efflux, ca influx
-decreased camp, inhibits voltage gated calcium channels in atria, activates a g protein that opens a k channel
M3
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
M3-Gq
location/effect: sympathetic-smooth muscle and glands-sweat glands increased activity and increased piloerector activity
location/effect: parasympathetic-
-bladder-contracts detrusor
-lungs-bronchoconstriction
-pupil-constriction, (miosis), ciliary, muscle contraction (accommodation)
-gi tract-increased motility
-increased salvation
-BB sludge subtract bradycardia
location/effect: EDRF-NO
-smooth muscle relaxation
-relax internal ureteral sphincter, lower esophageal sphincter, relax vessels supplying the ol’ point and shoot
-due to increase GTP, increased guanylyl cyclades, increased cGMP, increased vasodilation
smooth muscle contraction, glandular secretion
increased calcium release
smooth muscle and glands
increased calcium release
stimulates glandular secretions (sweat, gastric acid), ↑gut
peristalsis, pupillary sphincter, muscle contraction
M4-Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
M4-Gi
M5
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
M5-Gq increased calcium release
smooth muscle contraction, glandular secretion
Nn
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
Nn
ganglionic neuronal depolarization action potential
Nm
- Post synaptic/presynaptic?
- Which receptor? What happens due to receptor binding?
- location/organ and effect
Nm
NMJ depolarization, muscle contraction
Presynaptic receptors that appear to respond
to the NT released are called
autoreceptors
