Receptors In Cell Signalling, Receptor Structure And Common Structural Motifs (6) Flashcards
What is paracrine signalling?
- Signalling cell secretes local mediators to multiple target cells
What are the two main ways of intracellular signalling?
- Via secreted molecules
- Via plasma membrane-bound molecules
What is endocrine signalling?
- Signalling cell secretes hormone into blood stream to target cells
What is synaptic signalling?
- Neurotransmitters across synaptic clefts.
What are the two main types of molecules that are involved in intracellular signalling and how do they reach the target cell?
- Steroid
- Thyroid
- Via carrier proteins in the blood diffusing across membrane
What is the definition of a receptor?
- A molecule that recognises specifically a second molecule/family of molecules
- In response to ligand binding, regulation of cellular processes occur.
What role does a receptor have when unbound?
- Nothing
What is a ligand?
- Any molecule that binds specifically to a receptor site.
What do ligands do?
- May produce activation of a receptor - agonist
- May combine with a receptor site without causing activation - antagonist
Give comparisons of receptor affinity to enzyme affinity to ligand binding.
- Receptor: 10^-9M - 10^-6M
- Enzyme: 10^-6M - 10^-3M
How are receptors classified?
- Via specific physiological signalling molecule (agonist) recognised
How are receptors subclassified?
- Affinity (tightness of binding) of a series of antagonists
What are the agonists of the following:
- Nicotinic
- Muscarinic
- Nicotine
- Muscarine
What do the following muscarinic receptor subtypes bind to?
- M1
- M2
- M3
- M1: Pirenzipine
- M2: Gallanine
- M3: Hexahydrosiladiphenol
What is the difference between a receptor and an acceptor?
- Receptor: Silent at rest & antagonist binding stimulates a biological response
- Acceptor: Operates in absence of ligand & ligand binding alone produces no response