Electrical Excitabilty (5) Flashcards

0
Q

Via what mechanism are neurotransmitter released from vesicles?

A
  • Ca channels open and Ca influx occurs
  • Ca binds to synaptotagmin
  • Vesicles brought close to membrane
  • Snare complex makes a fusion pore
  • Transmitter released through this pore
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1
Q

What happens at the nerve terminal?

A
  • Depolarisation open voltage gated Ca channels
  • Ca entry
  • Increase in Ca conc inside
  • Causing release of neurotransmitter
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2
Q

ACh is released from the vesicles what does this do to stimulate an AP in the post synaptic axon?

A
  • ACh binds to nicotinic ACh receptor channels

- Na/K channel is ligand gated to ACh.

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3
Q

What is the end plate potential?

A
  • Depolarisation caused by binding of neurotransmitters to axon.
  • Activation of nAChR by ACh
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4
Q

What may cause a decrease in end plate potential?

A
  • Transmitter release is dependent on Ca entry

- If external Ca is lowered the end plate potential decreases in amplitude

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5
Q

How is ACh degraded?

A
  • ACh esterase in synaptic cleft
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6
Q

How does a depolarising blocker work?

A
  • Maintained depolarisation will fail to activate adjacent Na channels as they’ve become inactivated.
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7
Q

What are miniature end plate potentials?

A

Spontaneous release of vesicles without stimulus (~1/s)

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8
Q

What is myasthenia gravis?

A
  • Autoimmune disease targeting nAChR
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9
Q

What are the symptoms of Myasthenia gravis?

A
  • Profound weakness

- Weakness increases with exercise

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10
Q

What are the causes of Myasthenia gravis?

A
  • Antibodies directed against nAChR on post-synaptic membrane of skeletal muscle
  • Antibodies lead to loss of functional nAChR by complement mediated lysis and receptor degradation
  • Leads to end plate potentials decreasing in amplitude -> muscle weakness and fatigue
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11
Q

What is the possible treatment of Myasthenia gravis?

A
  • Inhibit ACh-esterase to allow more ACh
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12
Q

What does ACh also bind to other than nAChR?

A
  • Muscarinic AChR

- mAChR produces a slower response as they’re coupled to G proteins which trigger a cascade of events in the cell.

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13
Q

Outline what happens in an action potential in an axon.

A
  • Some K channels are open to establish resting potential via electrochemical gradient, so K influx until eqm is reached
  • Threshold value is reached, voltage gated Na channels open leading to depolarisation as Na influx occurs. Up to +30mv
  • At +30mv Na voltage gated channels become inactivated and are blocked until hyperpolarisation
  • K voltage gated channels open due to potential causing K efflux and repolarisation.
  • K permeability increases, all K voltage gated channels are open
  • Na are free from inactivation, no K voltage gated channels open - hyperpolarisation
  • Return to start, Na/K ATPase helps re-establish the ionic conc.
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14
Q

Why do we have unmyelinated axons?

A
  • Unmylinated is faster but dissipates over a long distance
  • So for pain unmyelinated is used as quick reactions are needed
  • But for long nerves such as musculo-cutaneous can’t use unmyelinated as would dissipate
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