Receptors and Signaling - Kruse

Question 1

Gs, AC, cAMP, Calmodulin, kinases – which hormones? (9)

Answer 1

LH, FSH, TSH
Glucagon
PTH, PTHrP
ACTH
GHRH, CRH

Question 2

Gi, AC inhibition, K+ and Ca++ channel activation (2)

Answer 2

Somatostatin, alpha-adrenergic

Question 3

Gq, PLC, IP3/DAG, PKC, voltage-gated Ca++ channels

Answer 3

TRH, GnRH

Question 4

RTK dimer, IRS-1 to IRS-4, Ras/Raf, MAP kinase

Answer 4

Insulin

Question 5

Cytokine receptor-linked kinase, JAK/STAT, Ras/Raf, MAP kinase

Answer 5

GH, Prolactin

Question 6

Serine/Threonine kinase, Smads

Answer 6

TGF-beta

Question 7

Homodimerization of nuclear receptor

Answer 7

Steroids (Glucocorticoids, Androgens, Progesterone, Estrogen)

Question 8

Heterodimerization of nuclear receptor

Answer 8

T3/T4, Vitamin D

Question 9

HRE

Answer 9

Hormone response element - where active nuclear receptor binds to initiate transcription