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Endocrine 2 > Hypothalamic and Pituitary Drugs - Kruse > Flashcards

Hypothalamic and Pituitary Drugs - Kruse Flashcards

1
Q

Somatropin, Somatotropin

A

Growth Hormone agonist

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2
Q

Mecasermin

A

IGF-1 agonist

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3
Q

Octreotide, Lanreotide

A

Somatostatin agonist

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4
Q

Pegvisomant

A

GH antagonist

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5
Q

Bromocriptine, Cabergoline

A

Dopamine agonist

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6
Q

Vasopressin, Desmopressin

A

ADH agonist

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7
Q

Conivaptan, Tolvaptan

A

ADH antagonists

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8
Q

GH (Somatropin) effects on:

  • Bone
  • Muscle
  • Fat
  • Blood sugar
A 
Bone = longitudinal growth
Muscle = anabolism
Fat = catabolism
Glucose = decreased
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9
Q

Uses of Somatropin (6)

A
  • Short stature (kids)
  • Prader-Willi
  • Turner syndrome
  • Noonan syndrome
  • AIDS cachexia
  • Short bowel syndrome
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10
Q

GH (Somatropin) toxicities - adults

A
  • Myalgias, arthralgias
  • Carpal tunnel syndrome
  • Peripheral edema
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11
Q

Somatropin contraindication

A

Malignancy

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12
Q

Mecasermin use

A

IGF-1 deficiency (not responsive to GH)

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13
Q

Mecasermin adverse effect

How to prevent?

A

Hypoglycemia

Eat 20 minutes before administration

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14
Q

Octreotide uses

A
  • GH-secreting adenomas (gigantism, acromegaly)
  • Other hormone-secreting tumors (Carcinoid syndrome, gastrinoma, glucagonoma, nesidioblastosis, diabetic diarrhea, WDHA syndrome)
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15
Q

Lanreotide use

A

Acromegaly

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16
Q

Adverse effects of octreotide/lanreotide

A

Gallbladder sludge, gallstones

17
Q

Somatostatin inhibitory functions (4)

A

Inhibits GH, glucagon, insulin, and gastrin

18
Q

Pegvisomant - MoA

A

GH receptor antagonist

19
Q

Pegvisomant - use

A

Acromegaly

20
Q

Bromocriptine, Cabergoline - use

A

Hyperprolactinemia

21
Q

Bromocriptine, Cabergoline - MoA

A

Dopamine D2 receptor agonist

22
Q

Vasopressin administration

A

IV, IM

23
Q

Desmopressin administration

A

IV, subQ, intranasal, oral

24
Q

Vasopressin - MoA

A

Activates V1 (vascular SM) and V2 (renal tubules) receptors to increase blood pressure

25
Q

Desmopressin - MoA

A

Activates V2 ONLY

26
Q

Vasopressin, Desmopressin - use

A

Central diabetes insipidus

27
Q

Vasopressin, Desmopressin - overdose S/S

A

Hyponatremia, seizures

28
Q

Conivaptan - MoA

A

V1 and V2 receptor antagonist

29
Q

Tolvaptan - MoA

A

V2 receptor-SELECTIVE antagonist

30
Q

Conivaptan, Tolvaptan - use

A

Euvolemic/hypervolemic hyponatremia (CHF, SIADH)

Endocrine 2 (12 decks)

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