Receptors and drugs

Question 1

Short acting drugs which block AchE?

Answer 1

• Reverisible binding

- Edrophorium

Question 2

What are A2 adrenergic receptors involved in?

Answer 2

Presynaptic inihibition of noradrenaline release

Question 3

How many transmembrane domains does an ionotropicc receptor have?

Answer 3

4

Question 4

What are the unwanted side effects of adrenoreceptor antagonists?

Answer 4

• Bronchoconstriction
• Cardiac depression
• Bradycardia
• Fatigue

Question 5

How many transmembrane domains does a GPCR have?

Answer 5

7

Question 6

What drug treats hypertension?

Answer 6

Clonidine (a A2 adrenoreceptor agonist)

Prazoin (A2 adrenoreceptor antagonist)

Question 7

What type of receptor is mAchR?

Answer 7

GPCR

Question 8

How is cholinergic transmission enchanced?

Answer 8

By drugs that inhibit acetlycholinasterase

- Present in the CSF, synaptic cleft and cholinergic nerve terminals

Question 9

Agonist of nAchR?

Answer 9

Nicotine

Question 10

Antagonist of GABAa?

Answer 10

• Picrotoxin

- Treats seizures

Question 11

Medium acting drugs which block AchE?

Answer 11

• Slow hydroloysis
• Neostigmine
• Pyridostigmine

Question 12

Antagonist of nAchR?

Answer 12

Curare

Question 13

Long acting drugs which block AchE?

Answer 13

• Irreversible binding
• Cross the blood-brain barrier
• Nerve gas
• Pesticides
• Organophosphates

Question 14

Where are B1 adrenergic receptors present?

Answer 14

In the heart

Question 15

How many transmembrane domains does a kinase linked receptor have?

Answer 15

1

Question 16

What type of receptors are adrenergic?

Answer 16

GPCR

Question 17

Agonist of GABAa?

Answer 17

GABA

Phenobarbitone

Question 18

Antagonist of opiate receptors?

Answer 18

Naloxone

Question 19

What does ephedrine treat and how?

Answer 19

Nasal congestion

- B agonist and an indirectly acting sympathomimeitc drug (causing NA release)

Question 20

B2 adrenoreceptor agonist?

Answer 20

Salbutamol

Question 21

What is the structure of glutamate receptors?

Answer 21

• 3 Transmembrane domains

- 4 subunits

Question 22

What does efficacy mean?

Answer 22

The ability of the drug-receptor complex to lead to intracellular signalling

Question 23

Structure of nAchR?

Answer 23

• 5 subunits, each channel has variations of these 5 subunits but a minimum of 2 alpha subunits are required
• Each subunit has 4 transmembrane domains
• 2 x Ach bind at the interphases between alpha to activate)

Question 24

Antagonist of mChR?

Answer 24

Atropine

Question 25

How many transmembrane domains does a nuclear receptor have?

Answer 25

0

Question 26

Where are A1 adrenergic receptors present?

Answer 26

In the smooth muscle

Question 27

Agonists of opiate receptors?

Answer 27

``` Endorphin Enkephalin Dynorphin Endomorphin Morphine Heroin ```

Question 28

What receptor type is nAchR?

Answer 28

Ligand gated

Question 29

What antagonist treats heart faliure?

Answer 29

Carvediol (A and B adrenoreceptor antagonist)

Question 30

Structure of a GPCR?

Answer 30

- 7 transmembrane domains | - 3 subunits

Question 31

What is the difference between GABAa and GABAb receptors?

Answer 31

GABAa is ionotropic, GABAb is a GPCR

Question 32

What is the structure of a P2X receptor?

Answer 32

- Ionotropic - ATP gated - 2 transmembrane domains - 3 subunits

Question 33

B adrenoreceptor antagonist?

Answer 33

Propanolol | - Treats anxiety

Question 34

Where are B2 adrenergic receptors present?

Answer 34

In the bronchioles

Question 35

How many helices do opiate receptors have?

Answer 35

8

Question 36

Agonist of mChR?

Answer 36

Muscarine | Pilocarpine