Receptor mechanism I Flashcards

1
Q

What does acetylcholine do to cardiac contraction?

A

Acetylcholine reduces cardiac contraction

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2
Q

What does acetylcholine do to smooth muscle contraction?

A

Increases contraction of smooth muscles

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3
Q

What is nicotinic cholinoreceptor activated by?

A

Activated by acetylcholine

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4
Q

What is 5HT3 activated by?

A

Activated by 5-HT

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5
Q

What is GABAA activated by?

A

GABAA activated by GABA

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6
Q

What is glycine receptor activated by?

A

Glycine

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7
Q

What ions do nicotinic receptors bind to and what happens to the membrane potential as a result?

A

The ions which bind are Na/Ca and causes the membrane to depolarise

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8
Q

What ions do 5HT3 receptors bind to and what happens to the membrane potential as a result?

A

The ions which bind are Na/Ca and causes the membrane to depolarise

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9
Q

What ions do GABAA receptors bind to and what happens to the membrane potential as a result?

A

The ions which bind are Cl and cause the membrane to hyperpolarise.

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10
Q

What ions do Glycine receptors bind to and what happens to the membrane potential as a result?

A

The ions which bind are Cl and cause the membrane to hyperpolarise.

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11
Q

Structure of Ligand gated ion channel receptor:

What site does a ligand gated ion channel receptor have?

A

Has a ligand binding site

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12
Q

Structure of Ligand gated ion channel receptor:

How many proteins is a ligand gated ion channel receptor made up of?

A

Made up of 5 proteins

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13
Q

Structure of Ligand gated ion channel receptor:

How many Transmembrane domains does each protein have?

A

Each protein has 4 transmembrane domains

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14
Q

Structure of Ligand gated ion channel receptor:

What do the amino acids in TM2 contribute to?

A

Amino acids in TM2 contribute to aqueous ionic pathway

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15
Q

What happens as soon as an agonist binds to a receptor?

A

Get a molecular kink

Ion pathway opens instantaneously

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16
Q

How many agonists needed for full opening of LGICR?

A

2 agonists needed for full opening of ion channels in LGICR

17
Q

What are the 2 superfamilies of nicotinic acetylcholine receptors?

A

N1 or NM in skeletal muscles end plates

N2 or NN in CNS and autonomic ganglia

18
Q

What does stimulation of nAChr in skeletal muscles do?

A

Stimulation of nAChr in skeletal muscles contracts muscle quickly

19
Q

What is the EJP?

A

Excitatory junction potential which is produced by influx of Na+ through nAChr

20
Q

Composition of N1 AChR’s

A

α1-ε-α1-β1-δ

21
Q

Composition of muscle nicotinic AChr’s

A

α1-ϒ-α1-β1-δ

22
Q

Composition of N2 AChr’s

A

α2-α8 and β2-β4

23
Q

What happens to muscle nAChr’s in myasthesia gravis?

A

Muscle nAChr’s become degraded

24
Q

What type of disease is myasthesia gravis?

A

Autoimmune disease

25
What does myasthesia gravis target and therefore what are unaffected?
Target the α1 subunit | Thus NN AChr's unaffected
26
What are the symptoms presented from patients suffering from myasthesia gravis?
Muscle weakness
27
What are missing with people suffering from myasthesia gravis?
Mepps are missing
28
What gives these mepps?
Acetylcholine vesicles always colliding with motor neurone all the time giving these mepps.
29
What does stimulation of GABAA receptors in neurones do?
Inhibit activity quickly
30
What are the steps that occur when GABAA in neurones are stimulated?
Inhibitory nerves release GABA or glycine GABAA receptors or glycine receptors are stimulated Aqueous ion pathway formed Cl- allowed to enter Result in hyperpolarisation Activity inhibited