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MRCPsych Part A > Recall > Flashcards

Recall Flashcards

good luck

1
Q
  1. Lurasidone mechanism of action.
A

D2, 5HT2a, 5HT7 antagonist - partial agonist at 5HT1A

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2
Q

What does Lurasidone not bind to?

A

Lurasidone does not bind to histaminergic or muscarinic receptors

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3
Q
  1. AD with Least sexual side effects
A

Vortioxetine

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4
Q
  1. Topiramate prominent side effect
A

Weight Loss

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5
Q

Prominent lithium side effect

A

Worsening Psoriasis

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6
Q

Which receptor does clozapine have greatest affinity

A

Alpha 1A/B

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7
Q

Lamotrigine mechanism of action

A

NMDA receptor modulation
Na Channels stable
Ca Channels blocked
Some GABA

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8
Q

NMDA receptor has greatest affinity for what compound?

A

Glutamate

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9
Q

Methamphetamine - highest affinity for which vesicle?

A

Dopamine vesicles

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10
Q

MDMA most affinity for which vesicle?

A

Serotonin Vesicles

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11
Q

NMDA molecular mechanism?

A

Glutamate receptor and ion channel
1/3 - AMPA and Kainate
CALCIUM ENTRY TO activate excitability

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12
Q

SERT Molecular mechanism

A

Na Dependent 5HT transporter
SLC6A4 gene
Transports back into presynaptic
UTILSISES SODIUM AND CHLORIDE FOR RE_ENTRY

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13
Q

Autoimmune encephalitis antibodies
Limbic activity, hyponatraemia - few Psych Sx

A

LGI1 antibody

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14
Q

Autoimmune encephalitis antibodies
3rd optic nerve and spine inflammation

A

AQP-4

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15
Q

Preserved in Schizophrenia?
Short/long/procedural/semantic

A

Procedural

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16
Q

What test do you use for short term memory? 5+ 2

A

Digit span

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16
Q

Test for abstract reasoning

A

Proverb test

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16
Q

Gene for Alpha synuclein

A

SNCA on Ch4

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16
Q

Cocktail Party Phenomenon
Selective vs involuntary

A

Selective Auditory attention

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16
Q

Meaning of words means…

A

Lexical semantics

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16
Q

Test for selective attention

A

Stroop test

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17
Q

Pathophysiology of korsakoffs

A

Mamillary body - alphaketoglutarate dysfunction

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17
Q

Pathophys of MSA

A

Alpha Synuclein in glial cells

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17
Q

Gene for P-glycoprotein

A

ABCB1 - MDR1 - Chr 7

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17
Q

Which molecule is component of BBB
Huntingtin/hypocretin/app/ApoE/Prion

A

APP

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18
Q

How many eps of depression to get recurrent?

A

2

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19
Q

Emotional memories occur in which phase of sleep

A

REM

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20
Q

A man is told he needs to get foot amputation, he is admitted and sees a patient who has had a similar surgery. He breaks equipment and says death is better than this.

Acute stress vs Adjustment

A

Acute stress

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21
Q

Difference between avoidant restrictive food intake and anorexia

A

Intentional weight loss

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22
Q

Difference between hoarding and OCD

A

Absence of obsessional thoughts

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23
Q

How long after grief can we diagnose grief disorder

A

6 months

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24
Q

Qualifier for depressive episode in ICD-11?

A

Melancholy

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25
Q

CHild is shocked and does not come close when offered help - attachmenmt disorder?

A

Reactive attachment disorder

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26
Q

What behaviour is seen in reactive attachment type?

A

Minimal seeking of comfort, inadequate childcare

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27
Q

CHild at daycare shows no reaction when left or collected by parents - style of attachment?

A

Avoidant attachment

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28
Q

Brain organoid represents which age in human

A

2nd trimester

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29
Q

Prazosin indicated for which condition?

A

Anxiety

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30
Q

Pindolol for which condition

A

Depression

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31
Q

Guanfacine for which condition?

A

ADHD

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32
Q

Greatest improvement of cognitive Sx in Schizophrenia with which NT?

A

Dopamine

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33
Q

Which drug abused by students for learning?

A

Amphetamine

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34
Q

Brain structure influences empathy?

A

Insula

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35
Q

Treatment for REM Sleep disorder

A

Melatonin

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36
Q

Which condition loses Orexin in neurons?

A

Narcolepsy

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37
Q

Atomextine MOA

A

Noradrenaline reuptake inhibitor

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38
Q

Nomothetic personality theory doesnt include

A

individual variability

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39
Q

Benefit of categorical classification of disorders?

A

Easy collection of epidemiological data

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40
Q

Bayes theory - an already held belief is also called

A

Priors

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41
Q

Most common inclusion in FTD

A

Tau +ve Amyloid -ve

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42
Q

LRRK2 mutation in which dementia

A

Parkinsons Chr 12

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43
Q

GPCR how many times passes through membrane?

A

7

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44
Q

Which AP reaches peak concentration fastest? Quetiapine, olanzapine, sulpiride, aripiprazole

A

Quetiapine

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45
Q

AOC in drugs denotes?

A

Exposure to drug over time

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46
Q

Absorption constant independent of …

A

Elimination constant

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47
Q

Campaign for harms of smoking used which kind of power? Referent/legitimate/information/expert

A

Information

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48
Q

Incorrect recall is what type of memory issue?

A

Retroactive falsification

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49
Q

Man is seeing faces as frightening and misshapen

chromat/metamorph/pelop/palino/parapropsia

A

paraprosopsia

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50
Q

What is palinopsia

A

Persistence of an image even after the image is removed

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51
Q

Complex PTSD is differentiated from PTSD by ..?

A

Poor interpersonal relationships

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52
Q

What brain structure has hypoplasia in Autism?

A

Cerebellar Vermis

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53
Q

What is true about purines?

A

Uncommon nitrogen containing compounds

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54
Q

Biological plausible genetic basis for schizophrenia?

A

DISC1

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55
Q

Metabolic syndrome present in which percentage of cases in CATIE trial?

A

41-50%

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56
Q

Research finding about altrusism?

A

Reduced physical perception of pain

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57
Q

Increased maternal sensitivity during attachment behaviour is due to increased connections between what brain structures?

A

Hippocampus & Amygdala

58
Q

NT that runs the Epigenetic mechanism by maternal attachment?

59
Q

Hallucinogenic effects of psychedelics produced by which receptor?

60
Q

Which test is used for assessing motor speed?

A

Finger Tap Test

61
Q

Non dominant side lesion causes which apraxia

A

Constructional apraxia

62
Q

Narrowest therapeutic index - Carbamazepine, Doxepin, Zopiclone, Clonazepam

A

Carbamazepine

63
Q

Piaget theory - most important feature of sensorimotor?

A

Object permanence

64
Q

Most biologically active metabolite - diazepam, lorazepam, oxazepam

65
Q

Which level of morality - fit in socially and perceived as nice person? Kohlberg

A

Conventional

66
Q

Default Mode Network involves which lobe?

A

Inferior parietal lobe

67
Q

Lobes of DMN

A

Medial prefrontal cortex
Angular gyrus (IPL)
Precuneus
posterior cingulate cortex

68
Q

Salience network structure

A

Cingulate cortex
Anterior insular
Thalamus
Striatum

69
Q

Central Executive

A

Dorsolateral prefrontal cortex
Intraparietal sulcus
Posterior Parietal cortex

70
Q

Interviewer rated scale depression

71
Q

Advantage of using cross sectional method in a study with children?

A

Quick data collection

72
Q

Test of premorbid intelligence

A

National Adult Reading test

73
Q

What is a predictor of alcohol dependence in young people?

A

Early onset of drinking

74
Q

In Vivo measurement of NTs

75
Q

FDG administration is used in which imaging modality

76
Q

Which ion channel is most implicated in schizophrenia?

77
Q

The concept that peoples interactions are influenced by each other and then each other in turn?

A

Circular causality

78
Q

The term for family members ganging up on other members

79
Q

EPS are produced at what percentage D2 occupancy

80
Q

Recombination fraction value that means two genes will be independently assorted

81
Q

Metabotropic receptors are which kind?

82
Q

1st line treatment of constipation in clozapine

83
Q

Deep brain stimulation in OCD targets what

A

Anterior Limb of internal capsule

84
Q

Dentate gyrus is a part of…

A

Hippocampus

85
Q

Which one requires longest duration for Dx - Schizoaffective/Adjustment/Schizophrenia/Delusional/Schizotypal

A

Schizotypal

86
Q

Aggression is reduced by

A

Observing the aggressor receive punishment

87
Q

What is extended in autistic children

A

Pre linguistic communication

88
Q

WHat is true about adolescent turmoil

A

Difficulties with parents is common

89
Q

Boy or girls more affected in child bereavement

A

Boys more affected than girls

90
Q

Conrad’s model : which stage does individual start to find new meaning for psychological processes

91
Q

Term for fluent plausible lying with fantastical elements

A

Pseudologia fantastica

92
Q

Southern blot for which molecular structure

93
Q

Gregory theory about perception

A

Perception depends on making inferences on past experiences

94
Q

Suboxone - which is naloxone with buprenorphine - benefit of mix?

A

Reduce chance of misuse

95
Q

Name of effect for lots of onlookers that do not help

A

Bystander effect

96
Q

What effect does the Polis exhibit when seeing a well dressed man at a crime scene and assumes all is well

A

Halo effect

97
Q

First rank symtpon example

A

Man sees clock strike 12 and believes he is messiah

98
Q

Last part of brain to be myelinated

A

Anterior front pole

99
Q

New info affecting old memories term?

A

Retroactive falsification

100
Q

Caffein effect is directly reversed by which receptors?

A

Adenosine receptors

101
Q

The name of effect when people wash their hands only when washed

A

Hawthorne effect

102
Q

Kraepelin - DP MD

A

Dementia Praecox & manic depression

103
Q

Bleuler - S

A

Schizophrenia

104
Q

Hecker - H

A

Hebephrenia

105
Q

Kahlbaum
Ca

106
Q

Morel DP

A

Demence Precoce

107
Q

kaSAnin

A

Schizoaffective

108
Q

Beard - N

A

Neurasthenia

109
Q

Kleist

A

Unipolar & Bipolar

110
Q

Braid(h)y

111
Q

Lewin - GD

A

Group Dynamics

112
Q

Moreno - GP

A

Group Psychotherapy

113
Q

Koch
Lil cock

A

Psychopathic Inferiority

114
Q

Reil - P

A

Psychiatry

115
Q

In BartoN

A

Institutional Neurosis

116
Q

James Lange theory of emotions?

James and the bobby > brain flakes > cry vomit shake

B > E

A

Emotions from Body sensations
Event - arousal - interpretation - emotion

117
Q

Cannon-bard theory of emotions (thalami)
CB = B + E

A

Emotion at same time as body sensation
simultaneous

118
Q

Singer-Schachter theory (2 factor)

C + B = E

A

Emotion from both physiology and context
Heart racing plus bad context
vs
Heart racing plus good context

119
Q

Lazarus theory of emotions?
T > E

A

Thought prior to emotion
Big dog - think of bite - feel afraid

120
Q

Erving Goffman ?

A

Stigma

Total Institution

121
Q

MECP2 condition?

A

Rett syndrome

122
Q

Delay & Deniker - Drug

A

Chlorpromazine

123
Q

Cerletti - Intervention

124
Q

Anthony Ryle - Therapy

A

Cognitive analytic therapy

125
Q

Rutter

A

Child Psychiatry

126
Q

Adler?

A

Personality drives superiority
Inferiority complex

127
Q

Eric Erickson

A

Stages of Psychsocial development

128
Q

Wilfred Bion

A

Group Dyanmics

129
Q

Anna Freud

A

Defence mechanism

130
Q

Otto Kernberg

A

Psychotherapy for PD

131
Q

Margaret Mahler

A

Child development

132
Q

Mahler stages

A

Autistic
Symbiotic
Separation-Individuation

133
Q

X-Linked Dom conditions?

A

Vitamin D resistant rickets

Rett Syndrome

134
Q

X-linked Recessive conditions

A

Cerebellar Ataxia
Hunter’s Syndrome
Lesch-Nyhan

135
Q

Mitochondrial conditions

A

Leber optic neuropathy
Kearns-Sayre

136
Q

AD conditions

A

NFT1 & 2
TS
Achondroplasia
Huntingtons Disease
Noonans syndrome

137
Q

AR Conditions

A

Cystic Fibrosis
Wilsons Disease
Friedrich’s ataxia
Tay-Sachs Disease
Homocystinuria
Phenylketonuria
Galactosaemia
Hurlers syndrome

138
Q

Sick role?

139
Q

Bobo doll experiment?

140
Q

PTSD medicines

A

Sertraline, Paroxetine

141
Q

Bulimia treatment

A

Fluoxetine

142
Q

AP with biggest weight gain x2

A

Clozapine and Olanzapine

143
Q

Jost law of memory

A

If two memories are equally strong, the more recent one will be forgotten more easily

144
Q

Bupropion moa

A

NA Dopamine transporter reuptake inhibition, nicotinic ach receptor antagonist

145
Q

Clonidine guanfacine moa

A

Alpha 1 agonism

146
Q

Thiamine - b number and conditions

A

B1

Beriberi
Wernicke

147
Q

Niacin b and condition

A

Pellagra- dementia dermatitis diarrhoea
B3

148
Q

Herpes encephalitis

Autonomic instability + jerks (friendly) + medial temp lobes

Which Ig?

149
Q

Herpes encephalitis

Hyponatraemia + faciobrachial seizures

Which Ig?

A

LGI1 antibody

150
Q

Herpes encephalitis

Psychosis and chewing

Which Ig?

A

NMDR antibody

151
Q

Which gene has been linked to dyslexia?

152
Q

Who coined cognitive dissonance

MRCPsych Part A (3 decks)

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