Recall Flashcards
good luck
1
Q
- Lurasidone mechanism of action.
A
D2, 5HT2a, 5HT7 antagonist - partial agonist at 5HT1A
2
Q
What does Lurasidone not bind to?
A
Lurasidone does not bind to histaminergic or muscarinic receptors
3
Q
- AD with Least sexual side effects
A
Vortioxetine
4
Q
- Topiramate prominent side effect
A
Weight Loss
5
Q
Prominent lithium side effect
A
Worsening Psoriasis
6
Q
Which receptor does clozapine have greatest affinity
A
Alpha 1A/B
7
Q
Lamotrigine mechanism of action
A
NMDA receptor modulation
Na Channels stable
Ca Channels blocked
Some GABA
8
Q
NMDA receptor has greatest affinity for what compound?
A
Glutamate
9
Q
Methamphetamine - highest affinity for which vesicle?
A
Dopamine vesicles
10
Q
MDMA most affinity for which vesicle?
A
Serotonin Vesicles
11
Q
NMDA molecular mechanism?
A
Glutamate receptor and ion channel
1/3 - AMPA and Kainate
CALCIUM ENTRY TO activate excitability
12
Q
SERT Molecular mechanism
A
Na Dependent 5HT transporter
SLC6A4 gene
Transports back into presynaptic
UTILSISES SODIUM AND CHLORIDE FOR RE_ENTRY
13
Q
Autoimmune encephalitis antibodies
Limbic activity, hyponatraemia - few Psych Sx
A
LGI1 antibody
14
Q
Autoimmune encephalitis antibodies
3rd optic nerve and spine inflammation
A
AQP-4
15
Q
Preserved in Schizophrenia?
Short/long/procedural/semantic
A
Procedural
16
Q
What test do you use for short term memory? 5+ 2
A
Digit span
16
Q
Test for abstract reasoning
A
Proverb test
16
Q
Gene for Alpha synuclein
A
SNCA on Ch4
16
Q
Cocktail Party Phenomenon
Selective vs involuntary
A
Selective Auditory attention
16
Q
Meaning of words means…
A
Lexical semantics
16
Q
Test for selective attention
A
Stroop test
17
Q
Pathophysiology of korsakoffs
A
Mamillary body - alphaketoglutarate dysfunction
17
Q
Pathophys of MSA
A
Alpha Synuclein in glial cells
17
Q
Gene for P-glycoprotein
A
ABCB1 - MDR1 - Chr 7
17
Which molecule is component of BBB
Huntingtin/hypocretin/app/ApoE/Prion
APP
18
How many eps of depression to get recurrent?
2
19
Emotional memories occur in which phase of sleep
REM
20
A man is told he needs to get foot amputation, he is admitted and sees a patient who has had a similar surgery. He breaks equipment and says death is better than this.
Acute stress vs Adjustment
Acute stress
21
Difference between avoidant restrictive food intake and anorexia
Intentional weight loss
22
Difference between hoarding and OCD
Absence of obsessional thoughts
23
How long after grief can we diagnose grief disorder
6 months
24
Qualifier for depressive episode in ICD-11?
Melancholy
25
CHild is shocked and does not come close when offered help - attachmenmt disorder?
Reactive attachment disorder
26
What behaviour is seen in reactive attachment type?
Minimal seeking of comfort, inadequate childcare
27
CHild at daycare shows no reaction when left or collected by parents - style of attachment?
Avoidant attachment
28
Brain organoid represents which age in human
2nd trimester
29
Prazosin indicated for which condition?
Anxiety
30
Pindolol for which condition
Depression
31
Guanfacine for which condition?
ADHD
32
Greatest improvement of cognitive Sx in Schizophrenia with which NT?
Dopamine
33
Which drug abused by students for learning?
Amphetamine
34
Brain structure influences empathy?
Insula
35
Treatment for REM Sleep disorder
Melatonin
36
Which condition loses Orexin in neurons?
Narcolepsy
37
Atomextine MOA
Noradrenaline reuptake inhibitor
38
Nomothetic personality theory doesnt include
individual variability
39
Benefit of categorical classification of disorders?
Easy collection of epidemiological data
40
Bayes theory - an already held belief is also called
Priors
41
Most common inclusion in FTD
Tau +ve Amyloid -ve
42
LRRK2 mutation in which dementia
Parkinsons Chr 12
43
GPCR how many times passes through membrane?
7
44
Which AP reaches peak concentration fastest? Quetiapine, olanzapine, sulpiride, aripiprazole
Quetiapine
45
AOC in drugs denotes?
Exposure to drug over time
46
Absorption constant independent of ...
Elimination constant
47
Campaign for harms of smoking used which kind of power? Referent/legitimate/information/expert
Information
48
Incorrect recall is what type of memory issue?
Retroactive falsification
49
Man is seeing faces as frightening and misshapen
chromat/metamorph/pelop/palino/parapropsia
paraprosopsia
50
What is palinopsia
Persistence of an image even after the image is removed
51
Complex PTSD is differentiated from PTSD by ..?
Poor interpersonal relationships
52
What brain structure has hypoplasia in Autism?
Cerebellar Vermis
53
What is true about purines?
Uncommon nitrogen containing compounds
54
Biological plausible genetic basis for schizophrenia?
DISC1
55
Metabolic syndrome present in which percentage of cases in CATIE trial?
41-50%
56
Research finding about altrusism?
Reduced physical perception of pain
57
Increased maternal sensitivity during attachment behaviour is due to increased connections between what brain structures?
Hippocampus & Amygdala
58
NT that runs the Epigenetic mechanism by maternal attachment?
Oxytocin
59
Hallucinogenic effects of psychedelics produced by which receptor?
5HT2A
60
Which test is used for assessing motor speed?
Finger Tap Test
61
Non dominant side lesion causes which apraxia
Constructional apraxia
62
Narrowest therapeutic index - Carbamazepine, Doxepin, Zopiclone, Clonazepam
Carbamazepine
63
Piaget theory - most important feature of sensorimotor?
Object permanence
64
Most biologically active metabolite - diazepam, lorazepam, oxazepam
Oxazepam
65
Which level of morality - fit in socially and perceived as nice person? Kohlberg
Conventional
66
Default Mode Network involves which lobe?
Inferior parietal lobe
67
Lobes of DMN
Medial prefrontal cortex
Angular gyrus (IPL)
Precuneus
posterior cingulate cortex
68
Salience network structure
Cingulate cortex
Anterior insular
Thalamus
Striatum
69
Central Executive
Dorsolateral prefrontal cortex
Intraparietal sulcus
Posterior Parietal cortex
70
Interviewer rated scale depression
HAMD
71
Advantage of using cross sectional method in a study with children?
Quick data collection
72
Test of premorbid intelligence
National Adult Reading test
73
What is a predictor of alcohol dependence in young people?
Early onset of drinking
74
In Vivo measurement of NTs
MRS
75
FDG administration is used in which imaging modality
PET
76
Which ion channel is most implicated in schizophrenia?
Calcium
77
The concept that peoples interactions are influenced by each other and then each other in turn?
Circular causality
78
The term for family members ganging up on other members
Detouring
79
EPS are produced at what percentage D2 occupancy
0.8
80
Recombination fraction value that means two genes will be independently assorted
0.5
81
Metabotropic receptors are which kind?
GPCR
82
1st line treatment of constipation in clozapine
Senna
83
Deep brain stimulation in OCD targets what
Anterior Limb of internal capsule
84
Dentate gyrus is a part of...
Hippocampus
85
Which one requires longest duration for Dx - Schizoaffective/Adjustment/Schizophrenia/Delusional/Schizotypal
Schizotypal
86
Aggression is reduced by
Observing the aggressor receive punishment
87
What is extended in autistic children
Pre linguistic communication
88
WHat is true about adolescent turmoil
Difficulties with parents is common
89
Boy or girls more affected in child bereavement
Boys more affected than girls
90
Conrad's model : which stage does individual start to find new meaning for psychological processes
Apophany
91
Term for fluent plausible lying with fantastical elements
Pseudologia fantastica
92
Southern blot for which molecular structure
DNA
93
Gregory theory about perception
Perception depends on making inferences on past experiences
94
Suboxone - which is naloxone with buprenorphine - benefit of mix?
Reduce chance of misuse
95
Name of effect for lots of onlookers that do not help
Bystander effect
96
What effect does the Polis exhibit when seeing a well dressed man at a crime scene and assumes all is well
Halo effect
97
First rank symtpon example
Man sees clock strike 12 and believes he is messiah
98
Last part of brain to be myelinated
Anterior front pole
99
New info affecting old memories term?
Retroactive falsification
100
Caffein effect is directly reversed by which receptors?
Adenosine receptors
101
The name of effect when people wash their hands only when washed
Hawthorne effect
102
Kraepelin - DP MD
Dementia Praecox & manic depression
103
Bleuler - S
Schizophrenia
104
Hecker - H
Hebephrenia
105
Kahlbaum
Ca
Catatonia
106
Morel DP
Demence Precoce
107
kaSAnin
Schizoaffective
108
Beard - N
Neurasthenia
109
Kleist
Unipolar & Bipolar
110
Braid(h)y
Hypnosis
111
Lewin - GD
Group Dynamics
112
Moreno - GP
Group Psychotherapy
113
Koch
Lil cock
Psychopathic Inferiority
114
Reil - P
Psychiatry
115
In BartoN
Institutional Neurosis
116
James Lange theory of emotions?
James and the bobby > brain flakes > cry vomit shake
B > E
Emotions from Body sensations
Event - arousal - interpretation - emotion
117
Cannon-bard theory of emotions (thalami)
CB = B + E
Emotion at same time as body sensation
simultaneous
118
Singer-Schachter theory (2 factor)
C + B = E
Emotion from both physiology and context
Heart racing plus bad context
vs
Heart racing plus good context
119
Lazarus theory of emotions?
T > E
Thought prior to emotion
Big dog - think of bite - feel afraid
120
Erving Goffman ?
Stigma
Total Institution
121
MECP2 condition?
Rett syndrome
122
Delay & Deniker - Drug
Chlorpromazine
123
Cerletti - Intervention
ECT
124
Anthony Ryle - Therapy
Cognitive analytic therapy
125
Rutter
Child Psychiatry
126
Adler?
Personality drives superiority
Inferiority complex
127
Eric Erickson
Stages of Psychsocial development
128
Wilfred Bion
Group Dyanmics
129
Anna Freud
Defence mechanism
130
Otto Kernberg
Psychotherapy for PD
131
Margaret Mahler
Child development
132
Mahler stages
Autistic
Symbiotic
Separation-Individuation
133
X-Linked Dom conditions?
Vitamin D resistant rickets
Rett Syndrome
134
X-linked Recessive conditions
Cerebellar Ataxia
Hunter's Syndrome
Lesch-Nyhan
135
Mitochondrial conditions
Leber optic neuropathy
Kearns-Sayre
136
AD conditions
NFT1 & 2
TS
Achondroplasia
Huntingtons Disease
Noonans syndrome
137
AR Conditions
Cystic Fibrosis
Wilsons Disease
Friedrich's ataxia
Tay-Sachs Disease
Homocystinuria
Phenylketonuria
Galactosaemia
Hurlers syndrome
138
Sick role?
Parsons
139
Bobo doll experiment?
Bandura
140
PTSD medicines
Sertraline, Paroxetine
141
Bulimia treatment
Fluoxetine
142
AP with biggest weight gain x2
Clozapine and Olanzapine
143
Jost law of memory
If two memories are equally strong, the more recent one will be forgotten more easily
144
Bupropion moa
NA Dopamine transporter reuptake inhibition, nicotinic ach receptor antagonist
145
Clonidine guanfacine moa
Alpha 1 agonism
146
Thiamine - b number and conditions
B1
Beriberi
Wernicke
147
Niacin b and condition
Pellagra- dementia dermatitis diarrhoea
B3
148
Herpes encephalitis
Autonomic instability + jerks (friendly) + medial temp lobes
Which Ig?
CASPR2
149
Herpes encephalitis
Hyponatraemia + faciobrachial seizures
Which Ig?
LGI1 antibody
150
Herpes encephalitis
Psychosis and chewing
Which Ig?
NMDR antibody
151
Which gene has been linked to dyslexia?
Dcdc2
152
Who coined cognitive dissonance
Festinger
