Ready To Study: The Cancer Patient Part 2 Continued Flashcards

1
Q

Often times we will do tumor removal or debulking before we try another modality because obviously ________ and ______ are going to be more effective if there’s less tumor there that needs to be removed. Palliation is relieving symptoms.

A

chemotherapy and radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The type of surgery chosen for cancer is determined by the ________ of the disease. if it’s a small tumor and it has well defined margins we are going to be able to remove the entire thing.

A

extent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The type of surgery chosen for cancer is determined by the _______ and ______ involved. Patients can have tumors that are growing around their trachea or around a major vessel like their aorta and obviously we aren’t going to be able to cut that out because we can’t get it and not damage something the pt needs to survive.

A

location and structures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The type of surgery chosen for cancer is determined by the _______. This is the speed of proliferation and reproduction.

A

tumor growth rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The type of surgery chosen for cancer is determined by the __________. It’s going to be harder to get the whole tumor if it’s deep within the tissues. Is the patient a good risk for surgery.

A

tumor invasiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The type of surgery chosen for cancer is determined by the ______ of the patient. People don’t have cancer alone. People have usually have cancer and COPD or cancer and cardiac disease. They might be a very high surgical risk or they might have no other options.

A

surgical risk
Study Tip: Liver cancer pt and she was fine in 50’s until she did a physical for life insurance and found she had liver cancer. She never had anything else going on, so had she been a candidate for surgery she would be a GOOD low surgical risk since she had no co-morbidities.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The type of surgery chosen for cancer is determined by the________. Sometimes it really is between does my pt want to have surgery and if so will they survive the surgery. Is there a possibility that their lungs are so compromised that their is a risk that they may never come off the ventilator? There are a lot of things you have to consider.

A

Quality of life expected post-op.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Surgery is used to ______. This is used to remove the entire cancer.

A

cure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Surgery is used as a component of ______ therapy, when used in addition to chemotherapy or radiation therapy.

A

adjuvant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Surgery is used to control oncologic emergencies like a _____ bleed.

A

GI bleed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Surgery can be done as ______. This can prevent the growth of cancer cells when genetic precursors have been detected.

A

prophylaxis.
Study Tip: Women have both breasts removed to prevent them from getting breast cancer since they have such a strong family history of breast cancer.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

__________ uses cutting and coagulating high frequency current to remove the malignancy or cancerous growth by needle, blade, or electrode.

A

Electrosurgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

__________ involves the insulation of very cold liquid nitrogen into the tumor and she had a lady w/ cancer and they injected her kidney w/ this very cold liquid nitrogen and it froze the kidney and it just dissolved in her body.

A

Cryosurgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Surgery is by far the most prevalent intervention for cancer 90% of all cancer patients undergo surgery. What is surgery used for?

A

Diagnosis
Staging
Tumor removal also called debulking
Palliation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

___________ is used in skin cancer so there’s a very corrosive paste that they will put on to the malignancy and remove it that way.

A

Chemosurgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

_________ they use a beam of laser energy to eliminate and to cut out a cancer.

A

Laser surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Used by > 50% of cancer patients it can be used alone or it can be used w/ other forms of treatment. It’s also used in conjunction with surgery it can be administered pre-op or post-op. ________ therapy can be used w/ chemo so we can use any combination of chemo, surgery, and this form of non-invasive therapy.

A

Radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

In patient’s with ________ the primary treatment is radiation but it might also be used to treat the CNS blood brain barrier because chemotherapy has some difficulty crossing this blood brain barrier. If we use radiation therapy on the CNS it can help the chemotherapy to cross easily into the blood brain barrier. Radiation therapy is used palliatively in about 50% of the patients who have advanced cancer.

A

acute lymphocytic leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

________ can reduce the size of a tumor, sometimes tumors grow and press on nerves which cause a lot of pain and it can be used palliatively for that and if a tumor is close to the spinal column it might threaten to compress on the spinal column and the pt would be paralyzed. Then they are going to be dying from cancer and be paralyzed from the waist down. A lot of times they will use radiation for that too.

A

Radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

There’s some oncologic emergencies like ________ where a tumor is growing around the superior vena cava, you can imagine the problems that’s going to cause. It’s going to interfere w/ blood returning to the heart, spinal cord compression which she already mentioned, bronchial obstruction, and hemorrhage.

A

superior vena cava syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Radiation can be used to treat all of these things. For what 6 cancers listed may this be the primary treatment.

A
List: 
Hodgkin’s
Early-stage breast cancer
Laryngeal
Prostate
Vaginal
Cervical
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

_________works by killing cells, it delays or halts the cell cycle, and it damages nucleus leading to cell death after replication. Rapidly proliferating cells are more vulnerable so we have the cancer cells that just keep going and going and going (like energizer bunny :P) they are going to be more vulnerable. However, you have to remember that normal tissue is vulnerable to treatment also. Normal tissue usually recovers between doses, the cancerous tissue cannot recover but still it’s very important to remember normal tissue is being affected by this treatment also.

A

Radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Radiation is curative it can be used alone to cure some cancers or in conjunction with chemotherapy. It can be a ______ which means it’s done before surgery. _________ means it’s done post-surgery.

A

neo-adjuvant

Adjuvant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Radiation can be used ________, some cancer cells have places they can go where they’re not accessible to chemotherapy or surgery.
An example like we mentioned earlier is the CNS it’s hard to get chemotherapy past the blood brain barrier so radiation is used to help that happen.

A

prophylactically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Radiation therapy is the ______ the dose and the _____ the intervals, the more likely it is to kill the cancer.
If we are just trying to palliate it’s just going to be a _____ dose over a shorter period of time. Radiation can be used palliatively, in lower doses over ______ intervals.

A

higher
longer
lower
shorter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Different types of radiation delivery and we don’t necessarily have to remember the different types like the EBRT vs. the SRT vs. the IMRT.
Those are all things that are administered externally so what we need to remember the difference between are those externally administered radiations vs. the other 2 the brachytherapy or systemic radiation?

A
External Beam Radiation Therapy (EBRT)
Sterotactic Radiation Therapy (SRT)
Brachytherapy:  temporary or permanent
Systemic
Intensity Modulated Radiation Therapy (IMRT)

FYI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

_______ is prescribed as a total dosage. A total dose is divided over treatments. It is 4,000 cGy/ 20 treatments and you get 200 cGy per treatment.
20 treatments over 4 weeks going Monday-Friday and by the end of that time they will have a total of 4,000 cGy.

A

Radiation

This is IMPORTANT.

28
Q

If you are at the hospital and you send a patient for radiation. The Oncology/Radiation unit should leave a note in the chart for when the patient comes back stating this is the 2nd treatment of radiation and we administered 200 cGys for a total of 400 cGys. They had 200 cGys the first time and 200 cGys the second time so both the nurse and radiation team keep a tally. Look at the most recent entry and ______ how far into the treatment your patient is and how much treatments they have left to go.

A

calculate

This is IMPORTANT.

29
Q

Formerly called RAD > Radiation Absorbed Dose now called ________.
1 RAD = 1 cGy
4,000 cGy = total amount of radiation absorbed by tissues
Divided into # of prescribed treatments.

A

Centigray

30
Q

The first treatment of ______ they go for will last a little bit longer than the rest since they have to line up the machine so they are radiating the most power and send the biggest amount of radiation right to the cancer itself. Remember it’s going to damage any tissue it grows through.

A

External Beam Radiation Therapy > EBRT
Study Tip: What tissue will be damaged? Skin. You know the skin is no matter what, there’s going to be some skin effects. Let’s say we have a woman w/ ovarian cancer (Story: pt w/ ovarian cancer in remission but she had severe gastroenteritis because of the radiation effects on her bowels.) That’s IMPORTANT to remember in a pt who has had radiation likewise there will be effects on the skin.

31
Q

This is very precise and this _______ treatment is used more often for the brain. You do not have memorize the differences in these it’s just good to see the differences in machinery.

A

Stereotactic Radiation Therapy

32
Q

_____ can be a temporary or permanent therapy. It is implanted into the effected body area. The material degrades and releases radiation into the surrounding tissue. You will see this in someone with probably prostate cancer since they insert the needle into the prostate gland and they put radioactive material in there.
What form of radiation therapy is this?

A

Brachytherapy

33
Q

Permanent beams/seeds??? are usually low level radiation and the radiation is blocked by the patients body. Their muscle, their fat, their organs and it is a very little risk to people around them. This can be permanent insulation or we can also do temporary implants and radiation beams and if you do that there’s some type of device that’s usually implanted. What form of radiation therapy is this?

A

Brachytherapy

34
Q

In a breast cancer patient they have long plastic straws that they’ll insert into the breast so that if you look at a woman from the front it almost looks like rays from a sun w/ those straws that pass through her breast so they’re sticking out from either side and they will slide the radioactive beams into those straws and as those beams dissolve or degrade over time it’s releasing radiation into the breast tissue. When you have somebody that has that and you’re in the hospital taking care of them you have to be careful, DO NOT have any pregnant people taking care of them or in the room. What form of radiation therapy is this?

A

Brachytherapy

Study Tip: We don’t want anyone going in that room that doesn’t have to be there, when you go in the room you stand away from the bed, you’re not going to go up and stand next to her and hold her hand. Those are things you need to remember for your safety.

35
Q

Imagine the pt will feel isolated and they should be told that beforehand but it’s still not an ideal situation but for the safety of the healthcare providers you really do need to minimize your contact and you’ll usually wear a device that’s recording the amount of radiation you’re getting so that it can be kept track of by your facility.
What form of radiation therapy is this?

A

Brachytherapy

36
Q

Given: IV, intralesion, or as encapsulated liquid we can use that for thyroid cancer, bone cancer and that’s about $10,000 a treatment and what they’ll do is just swallow that and it will go to the site that it’s supposed to be treated and there might be different directions for disposable body waste depending on what the substance is.
What form of radiation therapy is this?

A

Systemic Radiation Therapy

All you really need to know is it exists kind of an FYI.

37
Q

Treatments:
Radioactive iodine this is given orally to treats thyroid gland.
What form of radiation therapy is this?

A

I-131

38
Q

Treatments:
Treats cancers that have spread to the bone. These inhibit osteoblasts.
What form of radiation therapy is this?

A

Strontium 39

39
Q

This radiation therapy treatment is different because it doesn’t have to go in a straight line like the others do. It’s very sophisticated and very expensive.
What form of radiation therapy is this?

A

Intensity Modulated Radiation Therapy

FYI

40
Q

Adverse Effects of radiation therapy is that the dose is _________which means that it is dependent on the total amount that they receive. So if the patient is supposed to receive 4,000 cGy and the fractionation is the 200 cGy at a time the total becomes 20 treatments.

A

fractionation dependent

41
Q

Most frequently affected tissues in radiation therapy is the skin because no matter where you’re radiating it’s going through skin. It also affects the mucosal lining of the _____ because again depending on where it is and if it’s anything abdominal and it runs the whole length of your body except for your legs.
Bone marrow can really be affected and that can cause bone marrow production of cells to be thrown off.

A

GI tract

42
Q

Adverse effects can also be Acute or Chronic so there’s something that happens right around the time that they’re having the therapy or they might show up later.
Adverse Effects can be Mild or Severe they can also be local or systemic.
Also they are USUALLY ______ but can be systemic.

A

Local

43
Q
The 3rd prong on our assault on cancer if you want to look at it as a war is the anti-neoplastic therapy also known as chemotherapy. 
What is the goal? 
Is it to cure?
Is it to control? 
Is it for palliation? 
What are the answers to these questions?
A

Goal: Ask your patients this anytime you embark on a therapeutic relationship w/ them is what can I do for you today or what are we here to do?
Cure: Which means a prolonged absence of detectable cancer. There aren’t tumor markers, there aren’t symptoms, and we can’t see any cancer.
Control: Which it slows it down so that they have an extension of life.
Palliation: To comfort when cure and control isn’t possible.

44
Q

Palliation is management/reduction of side effects and symptoms, including pain. Chemotherapy is NOT used a whole lot for______ because it has some pretty unpleasant side effects that don’t contribute to comfort at all.

A

Palliation

45
Q

__________ is the biggest treatment modality against cancer. There is more than 30 different chemotherapeutic drugs and they’re used either alone or in combination. Usually they use higher doses of multiple drugs for a cure or to promote optimal palliation. If they use multiple drugs they can sometimes use lower doses also and maybe kind of avert some of the side effects. This may be a primary treatment or adjunct. It is the primary treatment for most hematological cancers.

A

Antineoplastic therapy AKA Chemotherapy

46
Q

_________ creates adverse conditions preventing cell growth/replication.
It does this by disrupting production of enzymes and inhibiting DNA, RNA, and protein synthesis and preventing cell mitosis.

A

Chemotherapy

47
Q

________ is most effective against cells and tumors with a high growth rate. That high growth rate doesn’t mean that they are growing rapidly it means that the percentage of cells actively dividing at a given point in time is greater. Generally smaller tumors are more effected by this treatment than our larger tumors because they have a greater percentage relatively speaking of cells that are growing.

A

Chemotherapy

48
Q

Then we have _______ that is cell cycle specific which interferes with steps in cycle. Then there are also other anti- neoplastic drugs that are cell cycle nonspecific which work in all stages.

A

chemotherapy

49
Q

Chemotherapy Approaches:
________: administered after surgery or radiation to eradicate residual malignant cells.
________: before surgery or radiation therapies.
________: used as the sole modality of treatment.
________: used as sole modality to temporarily control an incurable malignancy or to manage symptoms.
________: used in conjunction with either surgery or radiation.

A
Adjuvant
Neoadjuvant
Primary
Primary palliative
Combined Modality
IMPORTANT: FYI You don’t need to memorize what all of these things mean but you need to know chemotherapy can be used w/ radiation in surgery, it can be the primary, or it can be used primary for treatment or primary for palliation. Just understand this don’t memorize it.
50
Q

________ chemotherapy has an ongoing use which increases the probability of groups of resistant cells developing this is very similar to what happens with antibiotics. If you give somebody antibiotics their bacteria can develop a resistance, it’s the same way w/ this kind of chemotherapy.

A

Single agent

51
Q

________ Chemotherapy is often used because combined drugs will have a synergistic affect and also you’re going to alleviate or work against that buildup of resistance/tolerance to the medication.

A

Combination

52
Q

______ Chemotherapy in high doses is delivered to specific sites, we might do an abdominal perfusion of chemo, fill the abdominal cavity w/ chemo to treat ovarian cancer, or we might do an arterial perfusion to direct the chemo right to an affected tissue area.

A

Regional

53
Q

Chemotherapy drugs affect neoplastic cells and rapidly dividing normal cells.
The most common effects include; ______, ________, and ______ are common.

A

Anorexia, nausea, vomiting

54
Q

_________ is in adverse effect of chemo which is related to the emetic potential of the drug. Occurs within minutes or hours of administration. Usually subside in 24 to 48 hours. This is often relieved by anti-emetics.

A

Severity of vomiting

55
Q

young people
females
people w/ history of very little alcohol intake?
women who had a problem with emesis during pregnancy
people w/ a decreased quality of life
people who have chemo in the past.
These types of people are more susceptible to what adverse effect of chemotherapy?

A

There are people who are more susceptible to chemo induced nausea.

56
Q

There is a medication called _______ that can be used in combination w/ an anti-emetic the use of that is based on the results of one study but you will see this medication given pretty routinely to prep somebody right before the chemo to help w/ the nausea. GI stimulants can also be given to help with nausea.

A

Dexamethasone

57
Q

Another adverse effects of chemotherapy includes ________ because of increased gastric motility and maybe some lactose intolerance.

A

diarrhea

58
Q

Another adverse effects of chemotherapy includes _______ which is an irritation around the mouth.

A

Stomatitis

59
Q

Another adverse effects of chemotherapy includes _________because radiation can also cause this adverse effect on it’s own so again are you surprised at all that we have people that come in with neutropenia, thrombocytopenia, or pancytopenia.

A

Bone marrow suppression

Study Tip: This is really something that is not uncommon to see in a pt that’s being treated for cancer.

60
Q

Fatigue
Hair loss
Amenorrhea which is lack of a menstrual cycle
Low sperm count
fetal abnormalities
These are other adverse effects of __________.

A

chemotherapy

61
Q

Hormones are chemicals that are produced by glands in your body like ovaries or testicles, whichever one your patient has. Hormones can help some type of cancer cells to grow, such as ______ cancer and ______ cancer. In other cases hormones can actually kill cancer cells or make them grow more slowly or stop them from growing completely.

A

breast

prostate

62
Q

Cancer therapy can include giving hormones depending on if they’ve figured out if you have the type of cancer that’s responsive to hormones for growth or if hormones are going to kill them. Name the 5 hormones used?

A
Estrogens
Androgens
Prednisone
Dexamethasone
Methylprednisolone
63
Q

Obviously we aren’t going to give hormones if we have a cancer that likes hormones so if we are giving hormones we are only giving them to kill the cancer cells. Hormone therapy inhibits _______. It might outright just kill some of the cells and the side effects are directly related to normal action of hormones.

A

mitosis

64
Q
Breast cancer
prostate cancer 
adrenal cancer 
uterine cancer
These cancers will respond to what form of therapy and why?
A

Hormones are used for cancers responsive to or dependent on hormones for growth.
Study Tip: Hormones are cytotoxic to some cells.

65
Q

Biotherapy uses biologic response modifiers like __________ or _________ antibodies and change their response to cancer.

A

Interleukin 2 or Monoclonal

66
Q

Biotherapy uses hematopoietic growth factors like ________ which increases WBC production and cause neutrophils to divide and replicate or differentiate.

A

Filgrastim

67
Q

Biotherapy uses biologic response modifiers like ________ that can cause your body to increase production of RBCs. All of those are used as an adjunct to treatment of cancer to help work against the adverse effects that are going on in the pt.

A

Erythropoietin