Reading points - midterm 1 Flashcards

1
Q

explain the longitudinal study in 1945 on Hawaiian island set up

A

698 children studies for 40 years

  • physician records of mother and baby
  • family interactions at home studied
  • teachers interviewed
  • police, family court and social service records
  • IQ and personality tests
  • interviewed
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2
Q

explain the longitudinal study in 1945 on Hawaiian island results

A

showed both biological and environmental factors make up child development
prenatal or birth complications = more likely to develop disabilities
but degree of problems depended on parents income, education, mental health, quality of relationship
by 10 prenatal and birth problems were consistently related to psych difficuties only if child grew up in poor rearing conditions
bio + environ + family problems = serioua leanring and behavioural problems by 10. by 18 police record, mental health difficulties or unmarried parent
but 1/3 = resilient

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3
Q

3 breif reasons why we study child development

A

raising children
choosing social policies
understanding human nature

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4
Q

evidence on spanking children. alternative?

A

more often kids were spanked, worse they behaved
sympathy worked better
helping children find positive alternates for their anger

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5
Q

explain the turtle technique

A

when children feel angry they should remove themself form the situation and withdraw into their shell where they can think until they are ready to emerge from their shell
one study showed positive effects of this were seen 4 to 5 years after completing the curriculum

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6
Q

define meta-analysis

A

a method for combining the results from independent studies to reach conclusions based on all of them

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7
Q

what did a meta analysis of violent effects of violent video games find

A

no significant effect led to a law change

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8
Q

how much trust should we place on child testimony study

A

children play game of simon say
social worker given false script os what happened (but believes it to be true)
when asks children to recount what happened in the game 34% of children eventally changed their stories to corroborate with the social worker… effect of leading questions

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9
Q

explain the romanian adoption study set up

A

80s and 90s romainan orphanages = awful conditions, nurses actively encouraged not to touch children
malnourished, flat heads from lying on their backs so much, mental retardation, socially immature
adopted by uk parents
compared romainan adoptees to uk adoptees
also compared effect of how long had lived in the orphanage before being adopted

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10
Q

what were the results of the romainian adoption study

A

weight - if adopted pre 6 months by 6 yo = same weight as british. the later adopted, the less the children weighed
same story with intelligence - impaired visual memory and attention = biggest deficit
20% of post 6 month adoptees showed extremely abnormal behaviour aged 6 years. still persistent aged 15
brain development at 8 yo those who had spent substantial time in the orphanage had unusual low levels of neural activity in the amygdala

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11
Q

what conclusion can we draw from the romainian adoption study

A

the timing of experiences influence their effects

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12
Q

natursits argue… about human development

A

evolution has created capabilities we have from an early age

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13
Q

empiricists argue…. about human development

A

infants posses general learning mechanisms

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14
Q

brief overview of historical foundations of the study of child development

A

ealry philosophers (plato, aristotle, locke, rousseau)
social reforms movement
darwin
research-based theories

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15
Q

plato’s view of child developemtn

A

self contorl and discipline = most important goals of education
believed children born with innate knowledge

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16
Q

aristotle view of child development

A

agreed with plato in terms of discipline but more important to fit to the needs of the child
al knowledge occurs from experience

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17
Q

locke’s view of child development

A

child = tabula rasa (agreed with aristotle)
goal of child rearing = growth of character
parents need to set good examples
once discipline is instilled, treat as an adult as early as possible

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18
Q

Rosseau’s view of child development

A

give child max freedom from the beginningchild shouldn’t receive formal schooling until 12 - age of reason

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19
Q

what was the social reform movement born out of

A

undustrial revolution

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20
Q

how did darwin inspire child development

A

we should investigate child development as might give us insights into human nature
darwin’s baby biograpy = first methods of studying child development
still underlies ideas today

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21
Q

what are brief the 7 enduring themes in child development

A

nature vs nurture
the active child - how do children shape their own development
continuity / discontinuity
mechanisms of change - how does change occur
how does sociocultural context influence development
individual differences - how do children become so different from one another
research and children’s welfare - how can research promote childrens welfare

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22
Q

nature vs nuture of schizophrenia

A

nature - the closer the relation who has schizophrenia, the more likely you are to have schizophrenia yourself up to 50% (identical twin)
nurture - as is only 50% means environment must play a role. also adoptee studies show environmental impact (troubled families made it worse / more likely)

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23
Q

define genome

A

each persons complete set of herediary information

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24
Q

define epigenetics

A

the study of subtle changes in gene expression that are mediated by the environment

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25
define methylation
a biochemical process that influences behvaiour by supressing gene activity and expression
26
explain two study showing increased methylation
amount of stress mothers reported during their childs infancy was related to the amount of methylation in the childs genomes 15 years later increased methylation in the cord blood DNA of newborns of depressed mothers and adults who were abused as children
27
what do children attend to and form what age
faces 1 month chose to attend to mother 2 months show emotion to mothers face
28
when does speech being
9-15 months
29
what is crib speech and what does it show
toddlers when alone in a room wil often talk to themselves | shows language is internally motivated
30
difference in play between older and younger children
``` younger = pretend, learn how to cope with fear and interact with others older = more rule based = self control, turn taking, control own emotions ```
31
continuous development theory
the idea that changes with age occur gradually, often in small increments (like a tree growing)
32
discontinuous development theory
the idea that changes with age include occasional large shifts (caterpillar to butterfly)
33
define stage theories
approaches proposing that development involves a series of large, discontiuned age related phases
34
very brief piaget's theory of child development and how this relates to conservation of liquid problem
children go through 4 stages of cognitive growth 2-5 only attend to one piece of info at a time but by 7 can coordinate more aspects 4-5 yo fail liquid conservation, 7-8 yo pass
35
define cognitive development
the development of thinking and reasoning
36
how do we think of cognitive development today
stage theories are useful but outdated it is a gradual process supported by fact children show subtely different places of understanding depending which paradigm is used to test a particualr understanding
37
define effortful attention
voluntary control over ones emotions and thoughts (impulse control, emotional control, attentional contorl for example)
38
difficulty in effortful attention related with...
poor reading and maths | mental illness
39
brain areas implicated in effortful attention
limbic area anterior cingulate prefrontal cortex connections in these brain areas develop hugely during childhood. seems to be one mechanism underlying improving efforful attention during childhood development of these areas reflects environmental influences as well as genetics
40
define neurotransmitters
chemicals involved in communication between brain cells | - specific genes influence the production of key neurotransmitters
41
effect of genes and environment on effortful attention in children
infants with a particular form of one gene show differences in effortful attention based on the type of parenting they recieve among children who do not have that gene, quality of parenting has less of an effect
42
effects of training programme study in 5 and 6 yo in effortful attention
computerised exercises used to improve the capacity for effortful attention on examining the anterior cingulate cortex = 6 yo showed increased effortful attention and IQ increased
43
explain the study examining the role of sleep in promoting learning and generalisation
during first 18 months after birth, sleep appears to promote learning of general, frequently encountered patterns but not specific learning of material only presented once or twice but opposite pattern showed at 24 months
44
what is the active systems consolidation theory
2 interconnected brain areas (hippocampus - details of learnign after experience and cortex - abstraction of general patterns after many experiences) simultaneously encode new information during learning
45
when are hippocampal memories replayed and why
during sleep which allows opportunities for the cortex to extract general patterns from the specific memories (also works in opposite direction so learning general patterns improves retention of detials for new experineces of the same type
46
hypothesis why role of sleep changes 18-24 months
18-24 months, hippocampus is too immature to enable the rapid learning of the details of specific experineces - so sleeping doesnt benefit memory for these specifics but the cortex is mature enough to draw out general patterns
47
evidence to support hypothesis on role of sleep changes 18-24 months
number of exposures to a new word decreases considerably between 18-24 months pre 18 months dont remeber arbitrary presented sequences of events they have only seen once but after 24 months they do infants under 18 months who hear several unfamiliar words repeated just before they nap show a type of brain activity during sleep associated with cortical learning processes children with known impariments to the hippocampus have a much harder time retaining details of their experinces than peers
48
define sociocultural context
the physical, social, cultural, economic and historical circumstances that make up any child's environment
49
what does brofenbrenner's bioecological model take into account for childs development
people children interact with physical environment they live in institutions that govern their life general characteristics of society
50
descrbie cross cultural differences in where babies sleep
USA - parents bedroom at first, 2-6 months move to oen bedroom Japan, Italy, South Korea - same bed as mum for first few years and older children also in the same room. father can be in different room
51
define socioeconomic status
a measre of social class based on income and education
52
low SES in USA...
children do worse health problems in infancy more likely brain average less surface area more emotional problems smaller vocab and decreased IQ, math and reading more likely to have a baby out of marriage and drop out of school
53
define cumulative risk
the accumulation of disadvantages over years of development
54
3 characteristics of resilience
positive personal qualities close relationship with at least one parent close relationship with at least one other adult
55
Scarr's 4 factors that make children even from the same family different
genetic - even identical twins = diff gene mutations different treatment by parents and others different reactions to similar experineces = 69% of negative events triggered diff reactions in siblings different choices of environment - the active child
56
what is the active child
as children grow older they increasingly chose activities and friends for themselves = influence their own development
57
what were the results of interventional program that taught children they could improve their own intelligence
``` when told they were improved significantly more than their peers who were not teachers cited cihldren 3 times more who had this intervention as showing significant change in attiude and motivation in class than those who had not undergone this intervention ```
58
what are struggle stories
stories of real people who overcome problems and still do great things telling kids these works
59
explain the steps of the scientific method
question hypothesis develop a method to test the hypothesis use the resulting data to draw a conclusion regarding the hypothesis
60
reliabliity
the degree to which independent measures of a given behaviour are consistent
61
interrater reliabliity
the amount of agreement in the observstions of different raters who witness the same behaviour
62
test-retest reliability
the degree of similarity of a participants performance on two or more occasions
63
internal validity
can the effects of the experiment be attributed to variations that the researchers intentionally manipulated
64
external validity
how widely can the findings be generalized to different children in different places at different times
65
validity
the degree to which a test measures what it is intedned to measure
66
how does clinical interviews work
questions can be adjusted in accordance with the answers the interviewee provides
67
troubled family observation set up and results
naturalistic settings troubled = at least one child labelled as out of control income and age controlled fo parents of children in troubled homes = more self-absorbed and less responsive to their children viscious circle emerged 1 child acts hostiel or agressive 2 parents get angry 3 child escaltes level of hostility 4 parents escalate agression even further
68
positive and negative about naturalistic observation
can determine causeation | some beahviours only occur occasionally
69
what is structured observation
a method that involves presenting an identical situation to each participant and recording their behaviour
70
results of structured intervention study: | child asked to comply to mothers instructions to do less fun task then tidy up
child who complied wholeheartedly when first asked tended to avoid playing with the forbidden toys for longer, also more likey to comply and put toys away retested near 4th bday - showed same type of compliance they had as a toddler = stable
71
positives and negatives of structured observation
all children in same situation so direct comparisons can be made no extensive info about childs subjective experince not naturalistic or open ended
72
what are variables
attriubutes that vary across individuals and situations
73
what are correlational designs
studies intended to indicate how two variables are related to each other eg can estimate how long children spend reading based on their reading scores
74
direction-of-causation problem
the concept that a correlation between two variables does not indicate which, if either variables is the cause of another
75
third-variable problem
the concept that a correlation between two variables may stem from them both being influenced by some third variable
76
why do we use correlations when they can be so problematic
many varibales cannot be studied experimentally | sometimes we just want to know about relationships, not causes
77
define experimetnal designs
a group of approaches that allow inferences about causes and effects to be drawn
78
define random assignment
participants have an equal chance of being assigned to each group within an experiment
79
define experimental control
the ability of researchers to determine the specific experinences of participants during the course of the experiment
80
define experimental group
the group of participants in an experimental design who are presented the experince of interest
81
define control group
the group of participants in an experimental design who are not presented the experience of interest but in all other ways are treated similarly
82
what is a cross-sectional design
a research method in which participants of different ages are compared in a given behaviour of characteristic over a short period of time
83
what was found out about background TV and childs play
it disrupts it
84
what is a longitudinal desgin
a method of study in which the same participants are studies twice or more over a substantial length of time practical and validity questions
85
what is a micorgenetic design
a method of study in which the same participants are studies repeatedly over a short period of time in depth depiction of what causes change study development as it occurs
86
counting-on strategy study
microgenetic design 4 and 5 yo did not yet use the counting on strategy but knew how to add by counting from one 11 week period = lots more problems presented than normal discovered harder problems didn't start this change, it periodically started to appear even on easy problems generalisation tends to be slow
87
when would we use microgenetic designs and why
typically used when a basic pattern of age related change has already been established and the goal becomes to understand how change occurs
88
ethical issues in child developemtn research
research cannot harm children informed consent comes from the parent preserve anonymity discuss any results with parents which might be important to the child's welfare try counteract any foreseen negative consequences correct any inaccurate impressions the child may develop from the study
89
aristotle - view on prenatal life
is fetus all ready made just tiny | or does it develop in sucession
90
define epigenetics
the emergence of new structures and fucntions in te course of development - what aristotle thought
91
how did aristotle study develop
opening chick eggs
92
what do the Beng people of west africa believe about when life starts
every life is a reincanation of another | only when the stub drops off the umbilical cord does the new life begin
93
what are gametes
reproductive cells - egg and sperm that contain only half the genetic material of the other cells in the body
94
what is mitosis
all division that produces gametes with 1/2 genetic info
95
when are female eggs produced
during her prenatal development and that is all she gets
96
define conception
the union of an egg from the mother and sperm from the father
97
define zygote
a fertilised egg cell
98
define embryo
name given to the developing organism from 3rd to 8th week of prenatal development
99
define fetus
name from 9th week to birth
100
define mitosis
cell division that results in two identical daughter cells
101
sex differences in survivial and health
used to be thought there was a bis towards male showed not true is equal female fetuses less likely to survive early gestation, resulting in slight male bias at birth but male fragility
102
explain male fragility
``` males more likely to low birth weight fetla distress during labour learning disabilities higher infant mortality less likely to survive ```
103
what is cell migration
the movement of newly formed cells away from their point of origin
104
what is cell differentiation
after several divisions we start to get cell specialization`
105
define embryonic stem cells
no fixed function and can develop into any body cell | so how do we know what cell to turn into what , when and where
106
what is apoptosis
genetically programmed death
107
role of hormones in sex differentiation
if androgens are present then male testes develop | around the 8th week after conception the fetus can begin creating this hormone and if it does then boy
108
go through early development of zygote to fetus
journey through fallopian tube, doubles number of cells approx twice a day 4th day = hollow sphere with a bulge of cells called inner cell (identical twins most liekly to develop now) end of first week implantation in uterine lining and dependent on mother (only about 1/2 of zygotes conceived make this)
109
how identical twins occur
splitting in half of the zygote resulting in 2 zygotes
110
how fraternal twins occur
two eggs happen to be released into the fallopian tube at the same time and are fertilised by 2 different sperm so only half genes in common
111
define amniotic sac
a transparent fluid filled membrane that surrounds and protects the fetus
112
define placenta
support organ for the baby keeps circulatory systems of the mother and fetus separate but a semipermeable membrane permits the exchange of some materials between the two
113
define umbilical cord
a tube containing the blood vessels connecting the fetus and placenta
114
define neural tube
a groove formed in the top layer of differentiated cells in the embryo that eventually becomes the brain and spinal cord
115
after implantation of the zygote...
cell differentiation inner cell mass = embryo 3 layers each with different density (top - nervous systme, middle - bones, muscles, cirulatory system, inner layers of skin + internal organs, bottom - digestive system, lungs, urinary tract, glands) u shaped groove forms down centre of top layer folds at top move together and fuse - neural tube one end of this tube will swell and develop into the brain, the rest is the spinal cord
116
define habituation
a simple form of learning that involves a decrease in response to repeated or continued stimulation
117
define dishabituation
the introduction of a new stimulus rekindles interest following habituation to a repeated stimulus
118
fetal learning through habituation
fetuses as young as 30 weeks gestation show habituation to both visual and auditory stimuli indicating the CNS is sufficiently developed at this point for short term memory and learnign to occur heart rate increases to mothers own voice preference for own amniotic fluid after birth
119
define phylogenetic continuity and why is useful
the idea that because of our common evolutionary history, humans share many characterstics, behaviours and developmental processes with other animals especially mamals eg studying fetal alcohol syndrome in rats
120
what lasting effect does the things that happen in the womb leave ont he fetus
preferences of taste | dr seus story - preffered the version they were read in the womb
121
should we school our kids in the womb
no | amniotic sac means fetus can hear sounds and pitch, not individual words and no meaning understanding
122
most common hazard to fetuses
miscarriage - spontaneous abortion most tend to occure before mum even knows she is pregnant majority of fetuses that miscaryy very early have severe defects that make development impossible
123
define teratogens
an external agent that causes damage or death during prenatal development
124
what is the crucial thing in teratogens effect
their timing relative to development | many can only cause damage if are present during sensitive period of development
125
what was minamata disease
mercury poisoning of fetus by mother eating contaminated fish from a particular lake
126
define sensitive period
the period of time during which a developing organism is most sensitive to the effects of external factors; prenatally the sensitive period is when the fetus is maximally sensitive to the harmful effects of teratogens
127
thalidomide
50s and 60s serious birthd efect occured only if mother took drug during 4th and 6th week after conception was fine if took before or after
128
dose response relation
a relation in which the effect of exposure to an element increases with the extent of exposure
129
what makes some teratogens like smoking difficult to study
happen in combination eg smoking = low ses so more pollution anyway
130
define fetal prgramming
programme the physiological set points that will govern physiology in adulthood so prenatal malnourished mother - increased risk of obese child as nutritional deficiency in the womb never resets itself this was found in dutch hunger study (was useful as ses for example wasnt an issue)
131
explain the sleeper effects of teratogens example
DES used during pregnancy in 40s and 50s to prevent miscarriage in adolesence and adulthood their offspring had elevated rates of cervical and testicular cancer
132
antidepressents and pregnancy
treating depression during pregnancy can help reduce risj of postpartum depression we are unsure about the risks of antidepressants on babies evidence is inclusive CBT type approach will probably be best
133
opiods as teratogens
highly damaging - fetus can become addicted neonatal abstinence syndrom - form of drug withdrawal seen when fetus exposed to opiods in the womb are born -low birth weight, problems with breathing, feeding and seizures
134
illegal drugs as teratogens
as they are designed to mimic neurotransmitters = havoc with developing brain
135
cigarettes as teratogens
less O2 to fetus fetus breathes less whilst mother is smoking fetus will metabloize some of the cancer causing agents slowed fetal growth, low birth weight, increased infant death syndrome, decreased IQ, hearing deficits, cancer dose-response relationship timing - effects are greatest early in gestation
136
alcohol as teratogens
leading cause of fetal brain damage mothers tend to be +35, college educated and employed alcohol crosses placenta and goes into fetal bloodstream fetus has less ability to metabolize and remove alcohol so remains in fetuses system longer FAS - facial deformities, mental retardation, attention problems, hyperactivity
137
SIDS
sudden infant death syndrome infant under 1 year, doesn't seem to be a cause cultural influences - african and native americans most liekly, hispanic and asian least likely inadequate reflux response? as reflexes are in process of changing to prevent but baby to sleep on back (but do need to provide supervised tummy time)
138
environmental pollutants as teratogens
``` PCB exposure (lake michigan fish) - newborns with small heads, newborns who had undergone highest exposure had slightly lower IQ scores as long as 11 years later china - pollution related birth defects flint river water policy change - corrosion of water pipes so lead poisoning, neurotoxin, ADHD. disproportionatley effected low SES ```
139
maternal factors on fetal health
girsl under 15, baby more likely to die before first bday older mothers - fetal chromosomal abnormalities, birth complications, autism old father has also been implicated, ADHD increased risk
140
nutrition of mother
all babies nutrients come from mum too little folic acid = high risk neural tube deficits general malnutrition = slow growth of fetal brain. but hard to study as often SES at play but was studied during dutch hunger winter
141
diseases in mum that can effect baby | - rubella
if contracted early in pregnancy then major malformations, deafness, blindness, intellectual disability
142
diseases in mum that can effect baby | - STIs
cytomegalovirs (herpes) - most common cause of congenetial infedction in birth canal - blindness or even death HIV - can pass to fetus, breastmilk can transmit but could also protect?
143
diseases in mum that can effect baby | - influenza
schizophrenia x3 more likley if flu during first trimester. infection may act on genes that make individuals more vulnerable to mental illness
144
diseases in mum that can effect baby | - maternal illness
may lead to autism in children who are generally susceptible potentially die to high levels of cytotines in the developing brain or due to an autoimmune response
145
diseases in mum that can effect baby | - zika virus
microcephaly - small baby head issues in brain development sexual transmission
146
diseases in mum that can effect baby | - women's emotional state
difficult to test higher levels of mother stress = more active fetuses - probably linked to stress hormones mum released continues after birth - higher levels of behavioural problems in child at age 4 so maybe prenatal yoga and meditation is a solution
147
crying
evolution - we react to baby crying mother responds more than father? mum has more of the solutions (eg breastmilk) but mum and dad equally good at distinguishing their own babies crying from others crying increases after birth peaking at 6-8 weeks then decreases by 3-4months parental understanding of crying important to avoid abuse and general distress in parents sugar can help lower pain in mums arms can help
148
how does swaddling works
provudes a high level of tactile stimulation and warmth | practiced in many cultures
149
how should we respond when baby cries?
prompt response precited less cries months later vs infants where cries were ignored during the first 9 weeks cried less during the next 9 weeks
150
colic
excessive or inconsolable crying by a young infant for no apparent reason -allergy -immature gut development ends around 3 months leaving no ill effects
151
``` whats considered -normal birth rate -low birth rate -very low birth rate premature small for gestational age ```
7.5 pounds 5.5 pounds 3.3 pounds at 37 weeks or earlier weigh substantially less than is normal for whatever their gestational age
152
as a group LBW...
increased medical complications, neurosensory deficits, illness decreased education achievement, IQ but closely tied in with low SES
153
why might there be increased low birth rates in china
pollution so impaired O2 transport across the placenta
154
hypothesised pathway for why low birth weight babies have psychiatric and dev problems
white matter reduction, ventricular enlargement, and so abnormal brain development occurs
155
explain intervention program for LBW babies
parents now allowed to touch and interact kangeroo care - allowing skin to skin contact parents as incubators promote breastfeeding decreases mortality, increases growth and attatchment = quickler out of hospital to compensate for little touch, LBW babies recieve progamme of moving their arms and legs as when more active = more alert = gain weight parents singing to infant tend to be fussier, harder to get to sleep, harder to get a schedule going. in telling parents this it helps alot delayed dev milestones, closer to gestational age than birth age social support system for parents very important
156
3 important notes on intervention programmes
gains are moderate and diminish over time sucess on an intervention depends on the initial health status of the infant cumulative risk factors at play
157
Rutter's multiple-risk models
higher incidence in english children gwoing up in families with 4 or more risk factors
158
define genotype
the genetic material an individual inherits
159
define phenotype
the observeable experssion of the genotype including both characteristics and behaviour
160
define environment
every aspect of an individual and their surrpundings other than genes
161
what are the five realtions that are fundamental in the development of every child
parent's genetic contribution to childs genotype contribution of childs genotype to their phenotype contribution of childs environment to their phenotype influence of each childs phenotype to their environment infuence of childs environment on genotype
162
define chromosomes
molecules of DNA that transmit genetic information | chromosome are made up of DNA
163
define DNA
molecules that carry all the biochemical instructions involved in the formation and functioning of an organism
164
define genes
selections of chromosomes that are the basic unit of heredity in all living things
165
what is the human genome made up of
only 2% genes what we used to think of as junk DNA plays a supporting role in influencing genetic transmission by regulating the activity of protein-coding genes
166
explain human heredity
``` 46 chromosomes 23 pairs in the nucleaus of each cell sex = the exception, otherwise both are same general x shape one chromosome from each parent ```
167
sex determination
sex chormosome female - 2x male - 1x 1 y (little one) sperm contain both x and y so it is the sperm that decide the sex a gene on the y chromosome encodes a protein that triggers the prenatal formation of testes subsequently testes produce testosterone
168
define mutation
a change in a section of DNA random spontaneous error, others are caused by the environment most are harmful most occur in germ cells and can be passed to offspring occasionally makes offspring more viable = DARWIN
169
define crossing-over
the process by which sections of DNA switch from one chromosome to the other; crossing over promotes variability among individuals
170
explain dominant-recessive patterns and name diseases which transmit via this
occurs only when an individual has two recessive alleles for the condition PKU sickle-cell anemia (remeber malaria benefit) cycstic fibrosis tay-sachs
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name 3 genetic disorders resulting from a dominant allele
huntington disease neurofibromatosis FOXP2 - gene running in an english family producing speech, language and motor difficulties
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define heterozygous
carry one normal of the gene and one defected | so in the case of sickle cell would be protected against malaria but not poorly
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what is polygenetic inheritance
``` interaction among multiple inherited genes in conjunction with the environment eg cancer heart disease diabetes 1 and 32 asthma psychiatric disorders - autism, ADHD ```
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define GWAS
genome wide association studies | suggest each gene has just a small effect on its own
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explain sex linked inheritance with examples
some single gene conditions are carried on x chromosome and muhc more common in males as no second x to contain the dominant male pattern baldness hemeophilia red-green colour blindness ducheene muscular atrophy fragile x syndrome - most common form of heritable intellectual disability
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explain chromosomal abnormalities
zygote with wrong number of chromosomes tend not to survive down syndrome - mothers egg does not divide properly = extra chromome 21 (mum over 35 much more likely) kinefelter syndrome - extra x chromosome in men (small testes, elongated limbs, infertility) turner syndrome - missing x chromosome in women (XO) - short, stunted sexual development at puberty, inferitlity
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name two diseases resulting from gene abnormalities
williams syndrome - small section of 25 genes on chromosome 7. less deletion = less impariment 7q11.23 duplication syndrome = duplication of same genes that are missing in williams - weak speech and language but strong visuo-spatial skills
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explain regulator gene defects
regulator genes control the expression of other genes | eg male born with female genetalia
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explain 3 diseases of development that have some genetic base that we just dont understand yet
dyslexia - highly heritable tourettes - complex pattern autism - 500-1000 candidate genes associated, de novo mutations = non-inhertied mutations are associated
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define endophenotypes
intermediate phenotypes including the brain and nervous system that do not involve overt behaviour
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are all genes on at once
NO
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define regulator genes
genes that control the activity of other genes genes never function in isolation development = the continuous turning on and off of genes
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what proportion of genes have alleles
1/3
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define dominant allele
the allele that is present gets expressed
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define recessive allele
the allele that is not expressed if a dominant allele is present
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define hetero and homo zygous
heter - two different alleles for a trait | homo - having two of the same alleles for a trait
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define polygenetic inheritance
inheritance in which traits are governed by more than one gene
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define norm of reaction
all the phenotypes that can theoretically result from a given genotype in relation to all the environments in which it can survivie and develop eg - can be studies by placing non-human with same genotype in different environments
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explain PKU
disorder resulting from a defective recessive gene on chromosome 12 prevents metabolism of amino acid - phenylalamine if phenylalamine allowed to build up in the bloodstream = impaired brain development, severe intellectual development but tend to be identified shortly after birth and placed on a strict diet
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explain the link between child abuse and genotype
the effects of the abuse function with childs gentoype = combination of environment and genetic factors x-linked gene MAOA
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when is genetic testing done
at any point in life
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define pharmocogeneti testing
use info about individuals genetic makeup to determine which course of treatment is more liekly to be effective
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define carrier genetic testing
genetic testing used to determine whether prospective parents are carriers of specific disorders typically offerent to eastern european jewish parents - tay-sachs also to african americans as sickle cell to solve would use IVF
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define prenatal testing
genetic testing used to asses the fetuses risk for genetic disorders offered to all in usa encouraged in those with risj factors analyze maternal blood to screen (false negatives though) dignositc tests = fetal cells (amniocentisis = amniotic fluid 15-20 weeks, CVS = placenta 10-13 weeks)
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define aneuplodity
missing or extra chromosome trisomy 21 - down syndrome trisomy 18 - edwards syndrome trisomy 13 - patau syndrome
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define newborn screening
tests used to screen newborn infants for a range of genetic and non-genetic disorders all newborns in usa = heel prick test screening for 30-50 diff disease biomarkers
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define active child
the child is a source of their own developemtn active creators of their own environment nature evokes behaviours in others select own environment once self-locomotion begins
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explain methylation in identical twins and what this tells us
3yo = very similar 50 yo = very different how the environment changes our genes
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how does poor maternal care affect methylation
affects methylation of genes involved in glucocticoid receptors = then this influences how animals deal with stress themselves
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define behaviour genetics
the science concerned with how variation in behaviour and development results from the cobination of genetic and environmental factors
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define heritable
refers to any characteristics or traits that are influenced by heredity
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define mulitfactorial
refers to traits that are affected by both environmental as well as genetic factors
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what are the two premises that underlie how we separate the effects of environment and genes
individuals who are geneticlaly similar should be phenotypically similar ie behaviour should run in families individuals who are reared together should be more similar than those who are reared apart
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monozygotic vs fraternal twins
``` mono = identical frat = 50% gene similarity ```
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what do adoption studies show us
are given measures / traits more highly correlated with sibling or adopted family
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explain family studies of IQ
identical twins resemble each other more than fraternal as they get older the degree in variation acocunted for by their genetic similarity increases so genetic influences on intelligence increases with age people actively control their own environments as they get older so IQ matches genetic better
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define heritability
a statistical estimate of the proportion of the measured variance on a trait among individuals in a given population that is attributable to genetic differences among those individuals
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in the us heritability seems to vary as a function of ...
SES
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high heritability does not impl...
immutability | so we can still try to cure it
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GCTA-genome wide complex trait analysis found
childrens educational attainment and social advantage appear to share some of the same genetic roots same genes are involved in intelligence across age
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heritability rarely exceeds...
50% so environemtn must be at play
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define neurons
cells that are specialized for sending and receiving messages between the brain and all parts of the body as well as within the brain itself
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define sensory neurons
transmit information from sensory receptors that detect stimuli
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motor neurons...
transmit info from the brain to muscles and glands
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interneurons ....
intermediate between sensory and motor neurons
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what do glial cells do
cells in the brain that provide a variety of critical supportive functions outnumber neurons 10 to 1 formation of myelin sheath help with brain health - protect brain and aid in regeneration
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define cerebral cortex
the gray metter of the brain that plays a primary role in what is thought to be particularly human like functioning from seeing and hearing to feeling emotion
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define lobes
major areas of the cortex associated with general categories of behaviour
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``` the four lobes are responsbile for... occipital temporal parietal frontal ```
occipital - visual temporal - memory, visual recognition, processing emotion and auditory info parietal - spatial integration, sesnsory input integrating with memory frontal - organizing behaviour
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define associated areas
parts of the brain that lie between the major sensory and motor areas and that process and integrate inputs from these areas
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define cerebral hemispheres
the two halbes of the cortex; for the most part, sensory input from one side of the body goes to the opposite hemisphere of the brain
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define corpus callosum
a dense tract of nerve fibres that enable the two hemispheres of the brain to communicate
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define cerebral laterization
the specialization of the hemispheres of the brain for different models of processing
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define neurogenesis
the proliferation of neurons through cell division begins 42 days after conception virtually complete by midway point of gestation we do continue to generate new neurons thoughtout life can be inhibited by stress
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how do new neurons get to the right place
helped by radial glial cells that provide scaffolding
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define arborization
enormous increase in size and capacity of the dendritic tree
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define spines
formation on the dendrites of neurons that increase the dendrites capacity to form connections with other neurons
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define mylenation
the formation of myelin (white matter) AROUND THE AXONS OF NEURONS THAT SPREADS AND INCREASES INFORMation processing abilities -begins deep in the brain and moves out towards the cortex occurs rapidly after birth slows somewhat during toddlerhood continues into young adulthood
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what are ERPs
event related potentials change in the brains electrical activity that occur in response to the presentation of a particular stimulus eg ERps in response to native speech shows their language growth over the next few years
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MEG
detects magnetic fields generated by electrical currents in the brain noninvasive way to study fetal brain during the last trimester fetuses are encoding info about repetitions of sounds
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fMRI in child developemtn
child needs to be over 6 years old to stay still enough but can be used on sleeping infants as young as 2 days DTI - diffusion tensor imaging rs-fMRI = resting state fMRI - can be used to study how brain networks develop
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PET
positron emission topography - detects brain metabolic processes but involves injecting radioactive material into the brain primarily used for diagnosis
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NIRS
near infra-red spectroscopy detects metabolic changes that lead to differential absorption of infrared light in brain tissue head does not have to be totally still can be used on kids who have had cochlear implants (where fMRI cannot)
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explain the white matter differences between us and chimps as we develop
initial = same but then chimps show a mature pattern of mylenation at the point of sexual maturity earlier than observed in humans
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synaptogenesis
the process by which neurons form synapses with other neurons resulting in billions of connections note timing and rate of synapse production vary in different cortical areas complete much earlier in visual compared to frontal timing is likely to contribute to the onset of various abilities
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explain synapse elimination
overabundance of neurons and synapses from synaptogenesis
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what is synesthesia and when can humans experinece it
blending of different types of sensory input | in infancy before connections between sensry areas are yet to be pruned
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define synaptic pruning
the normal development process through which synapses that are rarely activated are diminated - occurs at different times in different brain areas - adolesence = major brain developemtn and pruning - amount of gray metter = huge decrease 11-12 years old